diff --git a/CHANGES.rst b/CHANGES.rst
index 635b7cc73a5..05ce203ddac 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -27,6 +27,9 @@ Changelog (Pillow)
   combination of \r and \n as line endings.
   [rickprice]
 
+- Fix CVE-2022-45199: Pillow before 9.3.0 allows denial of service via SAMPLESPERPIXEL.
+  [rickprice]
+
 - Fix CVE-2021-28676: FliDecode did not properly check that the block advance
   was non-zero, potentally leading to an infinite loop on load.
   [rickprice]
diff --git a/Tests/images/oom-225817ca0f8c663be7ab4b9e717b02c661e66834.tif b/Tests/images/oom-225817ca0f8c663be7ab4b9e717b02c661e66834.tif
new file mode 100644
index 00000000000..01dca594f53
Binary files /dev/null and b/Tests/images/oom-225817ca0f8c663be7ab4b9e717b02c661e66834.tif differ
diff --git a/Tests/test_file_tiff.py b/Tests/test_file_tiff.py
index be00a4f9cb8..34cbb7b67ad 100644
--- a/Tests/test_file_tiff.py
+++ b/Tests/test_file_tiff.py
@@ -2,7 +2,9 @@
 import sys
 from io import BytesIO
 
-from PIL import Image, TiffImagePlugin
+import pytest
+
+from PIL import Image, ImageFile, TiffImagePlugin, UnidentifiedImageError
 from PIL._util import py3
 from PIL.TiffImagePlugin import RESOLUTION_UNIT, X_RESOLUTION, Y_RESOLUTION
 
@@ -13,7 +15,6 @@
 
 class TestFileTiff(PillowTestCase):
     def test_sanity(self):
-
         filename = self.tempfile("temp.tif")
 
         hopper("RGB").save(filename)
@@ -223,8 +224,8 @@ def test_16bit_s(self):
         self.assertEqual(im.getpixel((0, 1)), 0)
 
     def test_12bit_rawmode(self):
-        """ Are we generating the same interpretation
-        of the image as Imagemagick is? """
+        """Are we generating the same interpretation
+        of the image as Imagemagick is?"""
 
         im = Image.open("Tests/images/12bit.cropped.tif")
 
@@ -616,6 +617,17 @@ def test_fd_leak(self):
         tmpfile = self.tempfile("temp.tif")
         import os
 
+    @pytest.mark.parametrize(
+        "test_file",
+        [
+            "Tests/images/oom-225817ca0f8c663be7ab4b9e717b02c661e66834.tif",
+        ],
+    )
+    def test_oom(self, test_file):
+        with pytest.raises(UnidentifiedImageError):
+            with Image.open(test_file) as im:
+                pass
+
         # this is an mmaped file.
         with Image.open("Tests/images/uint16_1_4660.tif") as im:
             im.save(tmpfile)
diff --git a/docs/releasenotes/6.2.2.5.rst b/docs/releasenotes/6.2.2.5.rst
index 4130c871073..a18c5c37bd5 100644
--- a/docs/releasenotes/6.2.2.5.rst
+++ b/docs/releasenotes/6.2.2.5.rst
@@ -37,3 +37,5 @@ This release addresses several critical CVEs.
                        Pillow in the open phase, before an image was accepted
                        for opening.
 
+:cve: `CVE-2022-45199`: Pillow before 9.3.0 allows denial of service via SAMPLESPERPIXEL.
+
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 0661c2ffb19..5d5df3abc53 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -261,6 +261,8 @@
     (MM, 8, (1,), 1, (8, 8, 8), ()): ("LAB", "LAB"),
 }
 
+MAX_SAMPLESPERPIXEL = max(len(key_tp[4]) for key_tp in OPEN_INFO.keys())
+
 PREFIXES = [
     b"MM\x00\x2A",  # Valid TIFF header with big-endian byte order
     b"II\x2A\x00",  # Valid TIFF header with little-endian byte order
@@ -1264,10 +1266,25 @@ def _setup(self):
         else:
             bps_count = 1
         bps_count += len(extra_tuple)
-        # Some files have only one value in bps_tuple,
-        # while should have more. Fix it
-        if bps_count > len(bps_tuple) and len(bps_tuple) == 1:
-            bps_tuple = bps_tuple * bps_count
+        bps_actual_count = len(bps_tuple)
+        samples_per_pixel = self.tag_v2.get(
+            SAMPLESPERPIXEL,
+            3 if self._compression == "tiff_jpeg" and photo in (2, 6) else 1,
+        )
+
+        if samples_per_pixel > MAX_SAMPLESPERPIXEL:
+            # DOS check, samples_per_pixel can be a Long, and we extend the tuple below
+            logger.error("More samples per pixel than can be decoded: %s", samples_per_pixel)
+            raise SyntaxError("Invalid value for samples per pixel")
+
+        if samples_per_pixel < bps_actual_count:
+            # If a file has more values in bps_tuple than expected,
+            # remove the excess.
+            bps_tuple = bps_tuple[:samples_per_pixel]
+        elif samples_per_pixel > bps_actual_count and bps_actual_count == 1:
+            # If a file has only one value in bps_tuple, when it should have more,
+            # presume it is the same number of bits for all of the samples.
+            bps_tuple = bps_tuple * samples_per_pixel
 
         # mode: check photometric interpretation and bits per pixel
         key = (