diff --git a/src/request-pipeline/destination-request/index.ts b/src/request-pipeline/destination-request/index.ts
index d065a5b0b..8386b63f5 100644
--- a/src/request-pipeline/destination-request/index.ts
+++ b/src/request-pipeline/destination-request/index.ts
@@ -49,13 +49,24 @@ export default class DestinationRequest extends EventEmitter implements Destinat
         this._send();
     }
 
+    private static _isHttp2ProtocolError (err: Error) {
+        return err['code'] === 'ERR_HTTP2_STREAM_ERROR' && err.message.includes('NGHTTP2_PROTOCOL_ERROR');
+    }
+
     private _sendRealThroughHttp2 (session: ClientHttp2Session) {
         const reqHeaders = formatRequestHttp2Headers(this.opts);
         const endStream  = !this.opts.body.length;
         const stream     = session.request(reqHeaders, { endStream });
 
         stream.setTimeout(this.timeout, () => this._onTimeout());
-        stream.on('error', (err: Error) => this._onError(err));
+        stream.on('error', (err: Error) => {
+            if (DestinationRequest._isHttp2ProtocolError(err)) {
+                session.destroy();
+                this._sendReal();
+            }
+            else
+                this._onError(err);
+        });
         stream.on('response', headers => {
             const http2res = createResponseLike(stream, headers);
 
diff --git a/test/server/proxy/http2-client-test.js b/test/server/proxy/http2-client-test.js
index 6a386847b..3e97fe17f 100644
--- a/test/server/proxy/http2-client-test.js
+++ b/test/server/proxy/http2-client-test.js
@@ -3,7 +3,8 @@ const { HTTP2_HEADER_STATUS }      = require('http2').constants;
 const { expect }                   = require('chai');
 const request                      = require('request-promise-native');
 const logger                       = require('../../../lib/utils/logger');
-const { clearSessionsCache }       = require('../../../lib/request-pipeline/destination-request/http2');
+const { noop }                     = require('lodash');
+const http2Utils                   = require('../../../lib/request-pipeline/destination-request/http2');
 const { CROSS_DOMAIN_SERVER_PORT } = require('../common/constants');
 
 const {
@@ -39,7 +40,6 @@ describe('https proxy', () => {
     }
 
     before(() => {
-
         const crossDomainDestinationServer = createDestinationServer(CROSS_DOMAIN_SERVER_PORT, true);
         const { app: httpsApp }            = crossDomainDestinationServer;
 
@@ -73,7 +73,7 @@ describe('https proxy', () => {
         restoreLoggerFn(logger.destination, 'onHttp2SessionCreated');
         restoreLoggerFn(logger.destination, 'onHttp2Unsupported');
         http2Server.close();
-        clearSessionsCache();
+        http2Utils.clearSessionsCache();
         httpsServer.close();
     });
 
@@ -124,4 +124,52 @@ describe('https proxy', () => {
                 expect(logs[1][0]).eql('https://127.0.0.1:2002');
             });
     });
+
+    // https://github.com/nodejs/node/issues/37849
+    it('Should resend a request through https if http2 stream is emitted a protocol error', () => {
+        const sessionMock = {
+            destroyCalled: false,
+
+            request: () => ({
+                setTimeout: noop,
+                write:      noop,
+
+                end: function () {
+                    setImmediate(() => this._errorHandler({
+                        code:    'ERR_HTTP2_STREAM_ERROR',
+                        message: 'Stream closed with error code NGHTTP2_PROTOCOL_ERROR'
+                    }));
+                },
+
+                on: function (eventName, fn) {
+                    if (eventName === 'error')
+                        this._errorHandler = fn;
+                }
+            }),
+
+            destroy: function () {
+                this.destroyCalled = true;
+            }
+        };
+
+        session.id = 'sessionId';
+
+        const storedGetHttp2Session = http2Utils.getHttp2Session;
+        const proxyUrl = getProxyUrl('https://127.0.0.1:2002/stylesheet');
+
+        http2Utils.getHttp2Session = () => sessionMock;
+
+        proxy.openSession('https://127.0.0.1:2000/', session);
+
+        return request(proxyUrl, { form: { key: 'value' } })
+            .then(body => {
+                http2Utils.getHttp2Session = storedGetHttp2Session;
+
+                const expected = fs.readFileSync('test/server/data/stylesheet/expected.css').toString();
+
+                compareCode(body, expected);
+                expect(logs[0]).eql('onHttp2Stream');
+                expect(sessionMock.destroyCalled).to.be.true;
+            });
+    });
 });