diff --git a/components/mention/mention.component.ts b/components/mention/mention.component.ts
index 737fb79656..b894ecb0cf 100644
--- a/components/mention/mention.component.ts
+++ b/components/mention/mention.component.ts
@@ -15,6 +15,7 @@ import {
 import { TemplatePortal } from '@angular/cdk/portal';
 import { DOCUMENT } from '@angular/common';
 import {
+  AfterViewInit,
   ChangeDetectionStrategy,
   ChangeDetectorRef,
   Component,
@@ -23,6 +24,7 @@ import {
   EventEmitter,
   Inject,
   Input,
+  NgZone,
   OnChanges,
   OnDestroy,
   OnInit,
@@ -35,7 +37,8 @@ import {
   ViewChildren,
   ViewContainerRef
 } from '@angular/core';
-import { fromEvent, merge, Subscription } from 'rxjs';
+import { fromEvent, merge, Observable, Subscription } from 'rxjs';
+import { startWith, switchMap } from 'rxjs/operators';
 
 import { DEFAULT_MENTION_BOTTOM_POSITIONS, DEFAULT_MENTION_TOP_POSITIONS } from 'ng-zorro-antd/core/overlay';
 import { BooleanInput, NzSafeAny } from 'ng-zorro-antd/core/types';
@@ -71,7 +74,6 @@ export type MentionPlacement = 'top' | 'bottom';
           class="ant-mention-dropdown-item"
           *ngFor="let suggestion of filteredSuggestions; let i = index"
           [class.focus]="i === activeIndex"
-          (mousedown)="$event.preventDefault()"
           (click)="selectSuggestion(suggestion)"
         >
           <ng-container *ngIf="suggestionTemplate; else defaultSuggestion">
@@ -90,7 +92,7 @@ export type MentionPlacement = 'top' | 'bottom';
   changeDetection: ChangeDetectionStrategy.OnPush,
   providers: [NzMentionService]
 })
-export class NzMentionComponent implements OnDestroy, OnInit, OnChanges {
+export class NzMentionComponent implements OnDestroy, OnInit, AfterViewInit, OnChanges {
   static ngAcceptInputType_nzLoading: BooleanInput;
 
   @Input() nzValueWith: (value: NzSafeAny) => string = value => value;
@@ -141,6 +143,7 @@ export class NzMentionComponent implements OnDestroy, OnInit, OnChanges {
   }
 
   constructor(
+    private ngZone: NgZone,
     @Optional() @Inject(DOCUMENT) private ngDocument: NzSafeAny,
     private cdr: ChangeDetectorRef,
     private overlay: Overlay,
@@ -167,6 +170,27 @@ export class NzMentionComponent implements OnDestroy, OnInit, OnChanges {
     }
   }
 
+  ngAfterViewInit(): void {
+    this.items.changes
+      .pipe(
+        startWith(this.items),
+        switchMap(() => {
+          const items = this.items.toArray();
+          // Caretaker note: we explicitly should call `subscribe()` within the root zone.
+          // `runOutsideAngular(() => fromEvent(...))` will just create an observable within the root zone,
+          // but `addEventListener` is called when the `fromEvent` is subscribed.
+          return new Observable<MouseEvent>(subscriber =>
+            this.ngZone.runOutsideAngular(() =>
+              merge(...items.map(item => fromEvent<MouseEvent>(item.nativeElement, 'mousedown'))).subscribe(subscriber)
+            )
+          );
+        })
+      )
+      .subscribe(event => {
+        event.preventDefault();
+      });
+  }
+
   ngOnDestroy(): void {
     this.closeDropdown();
   }
diff --git a/components/mention/nz-mention.spec.ts b/components/mention/nz-mention.spec.ts
index c47195886d..44fb6fec94 100644
--- a/components/mention/nz-mention.spec.ts
+++ b/components/mention/nz-mention.spec.ts
@@ -2,7 +2,7 @@ import { Directionality } from '@angular/cdk/bidi';
 import { DOWN_ARROW, ENTER, ESCAPE, RIGHT_ARROW, TAB, UP_ARROW } from '@angular/cdk/keycodes';
 import { OverlayContainer } from '@angular/cdk/overlay';
 import { ScrollDispatcher } from '@angular/cdk/scrolling';
-import { Component, NgZone, ViewChild } from '@angular/core';
+import { ApplicationRef, Component, NgZone, ViewChild } from '@angular/core';
 import { ComponentFixture, fakeAsync, flush, inject, TestBed, tick, waitForAsync } from '@angular/core/testing';
 import { FormsModule, ReactiveFormsModule } from '@angular/forms';
 import { By } from '@angular/platform-browser';
@@ -157,6 +157,26 @@ describe('mention', () => {
       expect(textarea.value).toEqual('@angular ');
     }));
 
+    it('should prevent default on the mousedown event when an option is clicked and should not run change detection', fakeAsync(() => {
+      textarea.value = '@a';
+      fixture.detectChanges();
+      dispatchFakeEvent(textarea, 'click');
+      fixture.detectChanges();
+      flush();
+
+      const appRef = TestBed.inject(ApplicationRef);
+      const option = overlayContainerElement.querySelector('.ant-mention-dropdown-item') as HTMLElement;
+      const event = new MouseEvent('mousedown');
+
+      spyOn(appRef, 'tick');
+      spyOn(event, 'preventDefault').and.callThrough();
+
+      option.dispatchEvent(event);
+
+      expect(event.preventDefault).toHaveBeenCalled();
+      expect(appRef.tick).not.toHaveBeenCalled();
+    }));
+
     it('should support switch trigger', fakeAsync(() => {
       fixture.componentInstance.inputTrigger = true;
       fixture.detectChanges();