diff --git a/src/material/datepicker/datepicker-base.ts b/src/material/datepicker/datepicker-base.ts
index ed28441ef6b7..d6c6376bee4c 100644
--- a/src/material/datepicker/datepicker-base.ts
+++ b/src/material/datepicker/datepicker-base.ts
@@ -51,6 +51,7 @@ import {
   inject,
 } from '@angular/core';
 import {CanColor, DateAdapter, mixinColor, ThemePalette} from '@angular/material/core';
+import {AnimationEvent} from '@angular/animations';
 import {merge, Subject, Observable, Subscription} from 'rxjs';
 import {filter, take} from 'rxjs/operators';
 import {_getFocusedElementPierceShadowDom} from '@angular/cdk/platform';
@@ -119,7 +120,8 @@ const _MatDatepickerContentBase = mixinColor(
   host: {
     'class': 'mat-datepicker-content',
     '[@transformPanel]': '_animationState',
-    '(@transformPanel.done)': '_animationDone.next()',
+    '(@transformPanel.start)': '_handleAnimationEvent($event)',
+    '(@transformPanel.done)': '_handleAnimationEvent($event)',
     '[class.mat-datepicker-content-touch]': 'datepicker.touchUi',
   },
   animations: [matDatepickerAnimations.transformPanel, matDatepickerAnimations.fadeInCalendar],
@@ -161,6 +163,9 @@ export class MatDatepickerContent<S, D = ExtractDateTypeFromSelection<S>>
   /** Emits when an animation has finished. */
   readonly _animationDone = new Subject<void>();
 
+  /** Whether there is an in-progress animation. */
+  _isAnimating = false;
+
   /** Text for the close button. */
   _closeButtonText: string;
 
@@ -240,6 +245,14 @@ export class MatDatepickerContent<S, D = ExtractDateTypeFromSelection<S>>
     this._changeDetectorRef.markForCheck();
   }
 
+  _handleAnimationEvent(event: AnimationEvent) {
+    this._isAnimating = event.phaseName === 'start';
+
+    if (!this._isAnimating) {
+      this._animationDone.next();
+    }
+  }
+
   _getSelected() {
     return this._model.selection as unknown as D | DateRange<D> | null;
   }
@@ -596,7 +609,9 @@ export abstract class MatDatepickerBase<
 
   /** Open the calendar. */
   open(): void {
-    if (this._opened || this.disabled) {
+    // Skip reopening if there's an in-progress animation to avoid overlapping
+    // sequences which can cause "changed after checked" errors. See #25837.
+    if (this._opened || this.disabled || this._componentRef?.instance._isAnimating) {
       return;
     }
 
@@ -612,7 +627,9 @@ export abstract class MatDatepickerBase<
 
   /** Close the calendar. */
   close(): void {
-    if (!this._opened) {
+    // Skip reopening if there's an in-progress animation to avoid overlapping
+    // sequences which can cause "changed after checked" errors. See #25837.
+    if (!this._opened || this._componentRef?.instance._isAnimating) {
       return;
     }
 
diff --git a/tools/public_api_guard/material/datepicker.md b/tools/public_api_guard/material/datepicker.md
index 992d012f98c4..a761685505fb 100644
--- a/tools/public_api_guard/material/datepicker.md
+++ b/tools/public_api_guard/material/datepicker.md
@@ -9,6 +9,7 @@ import { AbstractControl } from '@angular/forms';
 import { AfterContentInit } from '@angular/core';
 import { AfterViewChecked } from '@angular/core';
 import { AfterViewInit } from '@angular/core';
+import { AnimationEvent as AnimationEvent_2 } from '@angular/animations';
 import { AnimationTriggerMetadata } from '@angular/animations';
 import { BooleanInput } from '@angular/cdk/coercion';
 import { CanColor } from '@angular/material/core';
@@ -382,8 +383,11 @@ export class MatDatepickerContent<S, D = ExtractDateTypeFromSelection<S>> extend
     // (undocumented)
     _getSelected(): D | DateRange<D> | null;
     // (undocumented)
+    _handleAnimationEvent(event: AnimationEvent_2): void;
+    // (undocumented)
     _handleUserSelection(event: MatCalendarUserEvent<D | null>): void;
     _isAbove: boolean;
+    _isAnimating: boolean;
     // (undocumented)
     ngAfterViewInit(): void;
     // (undocumented)