diff --git a/src/material/dialog/dialog-container.ts b/src/material/dialog/dialog-container.ts
index 5b4ef223e287..b8d37b98c038 100644
--- a/src/material/dialog/dialog-container.ts
+++ b/src/material/dialog/dialog-container.ts
@@ -94,6 +94,8 @@ export class MatDialogContainer extends CdkDialogContainer<MatDialogConfig> impl
   /** Current timer for dialog animations. */
   private _animationTimer: ReturnType<typeof setTimeout> | null = null;
 
+  private _isDestroyed = false;
+
   constructor(
     elementRef: ElementRef,
     focusTrapFactory: FocusTrapFactory,
@@ -262,6 +264,10 @@ export class MatDialogContainer extends CdkDialogContainer<MatDialogConfig> impl
    * be called by sub-classes that use different animation implementations.
    */
   protected _openAnimationDone(totalTime: number) {
+    if (this._isDestroyed) {
+      return;
+    }
+
     if (this._config.delayFocusTrap) {
       this._trapFocus();
     }
@@ -275,6 +281,8 @@ export class MatDialogContainer extends CdkDialogContainer<MatDialogConfig> impl
     if (this._animationTimer !== null) {
       clearTimeout(this._animationTimer);
     }
+
+    this._isDestroyed = true;
   }
 
   override attachComponentPortal<T>(portal: ComponentPortal<T>): ComponentRef<T> {
diff --git a/src/material/dialog/dialog.spec.ts b/src/material/dialog/dialog.spec.ts
index e0bb260b1506..a35639bd42fa 100644
--- a/src/material/dialog/dialog.spec.ts
+++ b/src/material/dialog/dialog.spec.ts
@@ -40,6 +40,7 @@ import {
   inject,
   TestBed,
   tick,
+  waitForAsync,
 } from '@angular/core/testing';
 import {By} from '@angular/platform-browser';
 import {BrowserAnimationsModule, NoopAnimationsModule} from '@angular/platform-browser/animations';
@@ -965,7 +966,8 @@ describe('MDC-based MatDialog', () => {
       dialog.open(PizzaMsg, {disableClose: true, viewContainerRef: testViewContainerRef});
 
       viewContainerFixture.detectChanges();
-      flushMicrotasks();
+      flush();
+      viewContainerFixture.detectChanges();
 
       let backdrop = overlayContainerElement.querySelector('.cdk-overlay-backdrop') as HTMLElement;
       let input = overlayContainerElement.querySelector('input') as HTMLInputElement;
@@ -994,7 +996,8 @@ describe('MDC-based MatDialog', () => {
         });
 
         viewContainerFixture.detectChanges();
-        flushMicrotasks();
+        flush();
+        viewContainerFixture.detectChanges();
 
         let backdrop = overlayContainerElement.querySelector(
           '.cdk-overlay-backdrop',
@@ -1179,7 +1182,8 @@ describe('MDC-based MatDialog', () => {
       dialog.open(PizzaMsg, {viewContainerRef: testViewContainerRef});
 
       viewContainerFixture.detectChanges();
-      flushMicrotasks();
+      flush();
+      viewContainerFixture.detectChanges();
 
       expect(document.activeElement!.tagName)
         .withContext('Expected first tabbable element (input) in the dialog to be focused.')
@@ -1505,7 +1509,8 @@ describe('MDC-based MatDialog', () => {
       dialog.open(DialogWithoutFocusableElements);
 
       viewContainerFixture.detectChanges();
-      flushMicrotasks();
+      flush();
+      viewContainerFixture.detectChanges();
 
       expect(document.activeElement!.tagName)
         .withContext('Expected dialog container to be focused.')