diff --git a/components/list/__tests__/Item.test.tsx b/components/list/__tests__/Item.test.tsx
index da730596287c..2bf574d1c9b5 100644
--- a/components/list/__tests__/Item.test.tsx
+++ b/components/list/__tests__/Item.test.tsx
@@ -1,6 +1,6 @@
-import React from 'react';
+import React, { useEffect } from 'react';
 import List from '..';
-import { render } from '../../../tests/utils';
+import { pureRender, render } from '../../../tests/utils';
 import ConfigProvider from '../../config-provider';
 
 describe('List Item Layout', () => {
@@ -204,4 +204,30 @@ describe('List Item Layout', () => {
     );
     expect(ref.current).toHaveClass('ant-col');
   });
+  it('react key', () => {
+    const loadId: number[] = [];
+
+    const Demo = ({ id }: { id: number }) => {
+      useEffect(() => {
+        loadId.push(id);
+      }, []);
+
+      return <div>{id}</div>;
+    };
+    const getDom = (id = 1) => (
+      <List
+        dataSource={[{ id, title: `ant design` }]}
+        rowKey={item => item.id}
+        renderItem={item => (
+          <List.Item>
+            <Demo id={item.id} />
+          </List.Item>
+        )}
+      />
+    );
+    const { rerender } = pureRender(getDom(1));
+    rerender(getDom(3));
+    rerender(getDom(5));
+    expect(loadId).toEqual([1, 3, 5]);
+  });
 });
diff --git a/components/list/index.tsx b/components/list/index.tsx
index 32d12e07610a..28c002067c36 100644
--- a/components/list/index.tsx
+++ b/components/list/index.tsx
@@ -104,8 +104,6 @@ function List<T>({
     total: 0,
   };
 
-  const listItemsKeys: { [index: number]: React.Key } = {};
-
   const triggerPaginationEvent = (eventName: string) => (page: number, pageSize: number) => {
     setPaginationCurrent(page);
     setPaginationSize(pageSize);
@@ -135,9 +133,7 @@ function List<T>({
       key = `list-item-${index}`;
     }
 
-    listItemsKeys[index] = key;
-
-    return renderItem(item, index);
+    return <React.Fragment key={key}>{renderItem(item, index)}</React.Fragment>;
   };
 
   const isSomethingAfterLastItem = () => !!(loadMore || pagination || footer);
@@ -249,13 +245,14 @@ function List<T>({
   let childrenContent = isLoading && <div style={{ minHeight: 53 }} />;
   if (splitDataSource.length > 0) {
     const items = splitDataSource.map((item: T, index: number) => renderInnerItem(item, index));
-    const childrenList = React.Children.map(items, (child: React.ReactNode, index: number) => (
-      <div key={listItemsKeys[index]} style={colStyle}>
-        {child}
-      </div>
-    ));
     childrenContent = grid ? (
-      <Row gutter={grid.gutter}>{childrenList}</Row>
+      <Row gutter={grid.gutter}>
+        {React.Children.map(items, child => (
+          <div key={child?.key} style={colStyle}>
+            {child}
+          </div>
+        ))}
+      </Row>
     ) : (
       <ul className={`${prefixCls}-items`}>{items}</ul>
     );