diff --git a/lib/adapters/xhr.js b/lib/adapters/xhr.js
index 021da2a690..bbae45fb9c 100644
--- a/lib/adapters/xhr.js
+++ b/lib/adapters/xhr.js
@@ -61,8 +61,12 @@ export default isXHRAdapterSupported && function (config) {
       }
     }
 
-    if (utils.isFormData(requestData) && (platform.isStandardBrowserEnv || platform.isStandardBrowserWebWorkerEnv)) {
-      requestHeaders.setContentType(false); // Let the browser set it
+    if (utils.isFormData(requestData)) {
+      if (platform.isStandardBrowserEnv || platform.isStandardBrowserWebWorkerEnv) {
+        requestHeaders.setContentType(false); // Let the browser set it
+      } else {
+        requestHeaders.setContentType('multipart/form-data;', false); // mobile/desktop app frameworks
+      }
     }
 
     let request = new XMLHttpRequest();