diff --git a/lib/adapters/xhr.js b/lib/adapters/xhr.js
index bbae45fb9c..18b39f2aca 100644
--- a/lib/adapters/xhr.js
+++ b/lib/adapters/xhr.js
@@ -61,11 +61,16 @@ export default isXHRAdapterSupported && function (config) {
       }
     }
 
+    let contentType;
+
     if (utils.isFormData(requestData)) {
       if (platform.isStandardBrowserEnv || platform.isStandardBrowserWebWorkerEnv) {
         requestHeaders.setContentType(false); // Let the browser set it
-      } else {
-        requestHeaders.setContentType('multipart/form-data;', false); // mobile/desktop app frameworks
+      } else if(!requestHeaders.getContentType(/^\s*multipart\/form-data/)){
+        requestHeaders.setContentType('multipart/form-data'); // mobile/desktop app frameworks
+      } else if(utils.isString(contentType = requestHeaders.getContentType())){
+        // fix semicolon duplication issue for ReactNative FormData implementation
+        requestHeaders.setContentType(contentType.replace(/^\s*(multipart\/form-data);+/, '$1'))
       }
     }