diff --git a/packages/babel-helpers/src/helpers.ts b/packages/babel-helpers/src/helpers.ts
index b288be59b933..0753100ef98c 100644
--- a/packages/babel-helpers/src/helpers.ts
+++ b/packages/babel-helpers/src/helpers.ts
@@ -223,6 +223,7 @@ helpers.createClass = helper("7.0.0-beta.0")`
   export default function _createClass(Constructor, protoProps, staticProps) {
     if (protoProps) _defineProperties(Constructor.prototype, protoProps);
     if (staticProps) _defineProperties(Constructor, staticProps);
+    Object.defineProperty(Constructor, "prototype", {});
     return Constructor;
   }
 `;
diff --git a/packages/babel-plugin-transform-classes/test/fixtures/exec/prototype-descriptor.js b/packages/babel-plugin-transform-classes/test/fixtures/exec/prototype-descriptor.js
new file mode 100644
index 000000000000..6a542c15103c
--- /dev/null
+++ b/packages/babel-plugin-transform-classes/test/fixtures/exec/prototype-descriptor.js
@@ -0,0 +1,16 @@
+class A {}
+class B extends A {}
+
+expect(Object.getOwnPropertyDescriptor(A, "prototype")).toEqual({
+  value: A.prototype,
+  configurable: false,
+  enumerable: false,
+  writable: false,
+});
+
+expect(Object.getOwnPropertyDescriptor(B, "prototype")).toEqual({
+  value: A.prototype,
+  configurable: false,
+  enumerable: false,
+  writable: false,
+});