diff --git a/packages/babel-plugin-proposal-optional-chaining/src/index.js b/packages/babel-plugin-proposal-optional-chaining/src/index.js
index 2cfce5263b46..604f5a4fe8f4 100644
--- a/packages/babel-plugin-proposal-optional-chaining/src/index.js
+++ b/packages/babel-plugin-proposal-optional-chaining/src/index.js
@@ -44,6 +44,11 @@ export default declare((api, options) => {
             optionalPath.node.type = "CallExpression";
             optionalPath = optionalPath.get("callee");
           }
+
+          // unwrap a TSNonNullExpression if need
+          if (optionalPath.isTSNonNullExpression()) {
+            optionalPath = optionalPath.get("expression");
+          }
         }
 
         let replacementPath = path;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/input.ts b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/input.ts
new file mode 100644
index 000000000000..f263a5b2dfb3
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/input.ts
@@ -0,0 +1,8 @@
+a?.b!.c;
+a?.b!.c.d;
+a?.b.c!.d;
+a!.b?.c;
+a?.b!?.c;
+a?.b!.c?.c;
+(a?.b!).c;
+(a?.b)!.c;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/options.json b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/options.json
new file mode 100644
index 000000000000..d48b5d0e7350
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/options.json
@@ -0,0 +1,6 @@
+{
+  "plugins": [
+    "proposal-optional-chaining",
+    "syntax-typescript"
+  ]
+}
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/output.js b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/output.js
new file mode 100644
index 000000000000..5bcddf99c677
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-optional-chaining/output.js
@@ -0,0 +1,10 @@
+var _a, _a2, _a3, _b, _a4, _ref, _a5, _c, _a6, _a7;
+
+(_a = a) === null || _a === void 0 ? void 0 : _a.b!.c;
+(_a2 = a) === null || _a2 === void 0 ? void 0 : _a2.b!.c.d;
+(_a3 = a) === null || _a3 === void 0 ? void 0 : _a3.b.c!.d;
+(_b = a!.b) === null || _b === void 0 ? void 0 : _b.c;
+(_a4 = a) === null || _a4 === void 0 ? void 0 : (_ref = _a4.b!) === null || _ref === void 0 ? void 0 : _ref.c;
+(_a5 = a) === null || _a5 === void 0 ? void 0 : (_c = _a5.b!.c) === null || _c === void 0 ? void 0 : _c.c;
+((_a6 = a) === null || _a6 === void 0 ? void 0 : _a6.b)!.c;
+((_a7 = a) === null || _a7 === void 0 ? void 0 : _a7.b)!.c;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/input.ts b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/input.ts
new file mode 100644
index 000000000000..f263a5b2dfb3
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/input.ts
@@ -0,0 +1,8 @@
+a?.b!.c;
+a?.b!.c.d;
+a?.b.c!.d;
+a!.b?.c;
+a?.b!?.c;
+a?.b!.c?.c;
+(a?.b!).c;
+(a?.b)!.c;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/options.json b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/options.json
new file mode 100644
index 000000000000..7249169ec0aa
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/options.json
@@ -0,0 +1,3 @@
+{
+  "plugins": ["proposal-optional-chaining", "transform-typescript"]
+}
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/output.js b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/output.js
new file mode 100644
index 000000000000..8af9f8dc0f23
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts-and-optional-chaining/output.js
@@ -0,0 +1,10 @@
+var _a, _a2, _a3, _b, _a4, _ref, _a5, _c, _a6, _a7;
+
+(_a = a) === null || _a === void 0 ? void 0 : _a.b.c;
+(_a2 = a) === null || _a2 === void 0 ? void 0 : _a2.b.c.d;
+(_a3 = a) === null || _a3 === void 0 ? void 0 : _a3.b.c.d;
+(_b = a.b) === null || _b === void 0 ? void 0 : _b.c;
+(_a4 = a) === null || _a4 === void 0 ? void 0 : (_ref = _a4.b) === null || _ref === void 0 ? void 0 : _ref.c;
+(_a5 = a) === null || _a5 === void 0 ? void 0 : (_c = _a5.b.c) === null || _c === void 0 ? void 0 : _c.c;
+((_a6 = a) === null || _a6 === void 0 ? void 0 : _a6.b).c;
+((_a7 = a) === null || _a7 === void 0 ? void 0 : _a7.b).c;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/input.ts b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/input.ts
new file mode 100644
index 000000000000..f263a5b2dfb3
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/input.ts
@@ -0,0 +1,8 @@
+a?.b!.c;
+a?.b!.c.d;
+a?.b.c!.d;
+a!.b?.c;
+a?.b!?.c;
+a?.b!.c?.c;
+(a?.b!).c;
+(a?.b)!.c;
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/options.json b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/options.json
new file mode 100644
index 000000000000..5c79172a6082
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/options.json
@@ -0,0 +1,3 @@
+{
+  "plugins": ["transform-typescript"]
+}
diff --git a/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/output.js b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/output.js
new file mode 100644
index 000000000000..b6d13e7877e7
--- /dev/null
+++ b/packages/babel-plugin-proposal-optional-chaining/test/fixtures/regression/10959-transform-ts/output.js
@@ -0,0 +1,8 @@
+a?.b.c;
+a?.b.c.d;
+a?.b.c.d;
+a.b?.c;
+a?.b?.c;
+a?.b.c?.c;
+(a?.b).c;
+(a?.b).c;