diff --git a/packages/babel-plugin-transform-react-jsx/src/create-plugin.ts b/packages/babel-plugin-transform-react-jsx/src/create-plugin.ts
index d4afe577f25c..982083f1671e 100644
--- a/packages/babel-plugin-transform-react-jsx/src/create-plugin.ts
+++ b/packages/babel-plugin-transform-react-jsx/src/create-plugin.ts
@@ -31,11 +31,12 @@ const DEFAULT = {
   pragmaFrag: "React.Fragment",
 };
 
-const JSX_SOURCE_ANNOTATION_REGEX = /\*?\s*@jsxImportSource\s+([^\s]+)/;
-const JSX_RUNTIME_ANNOTATION_REGEX = /\*?\s*@jsxRuntime\s+([^\s]+)/;
+const JSX_SOURCE_ANNOTATION_REGEX =
+  /^\s*\*?\s*@jsxImportSource\s+([^\s]+)\s*$/m;
+const JSX_RUNTIME_ANNOTATION_REGEX = /^\s*\*?\s*@jsxRuntime\s+([^\s]+)\s*$/m;
 
-const JSX_ANNOTATION_REGEX = /\*?\s*@jsx\s+([^\s]+)/;
-const JSX_FRAG_ANNOTATION_REGEX = /\*?\s*@jsxFrag\s+([^\s]+)/;
+const JSX_ANNOTATION_REGEX = /^\s*\*?\s*@jsx\s+([^\s]+)\s*$/m;
+const JSX_FRAG_ANNOTATION_REGEX = /^\s*\*?\s*@jsxFrag\s+([^\s]+)\s*$/m;
 
 const get = (pass: PluginPass, name: string) =>
   pass.get(`@babel/plugin-react-jsx/${name}`);
diff --git a/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/input.js b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/input.js
new file mode 100644
index 000000000000..91ca8e5f2fcd
--- /dev/null
+++ b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/input.js
@@ -0,0 +1,5 @@
+/**
+ * @jsx jsx
+ */
+
+<foo />
\ No newline at end of file
diff --git a/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/output.js b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/output.js
new file mode 100644
index 000000000000..2e9ea6eff28e
--- /dev/null
+++ b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-allow-jsx-docs-comment-with-pragma/output.js
@@ -0,0 +1,4 @@
+/**
+ * @jsx jsx
+ */
+jsx("foo", null);
diff --git a/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/input.js b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/input.js
new file mode 100644
index 000000000000..3aa8b3c8fe05
--- /dev/null
+++ b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/input.js
@@ -0,0 +1,2 @@
+// Make sure not to use a jsx pragma here (like "@jsx Something"), we need this to be React.createElement!
+<blah/>
diff --git a/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/output.js b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/output.js
new file mode 100644
index 000000000000..940ac582d73d
--- /dev/null
+++ b/packages/babel-plugin-transform-react-jsx/test/fixtures/react/should-not-allow-jsx-pragma-to-be-anywhere-in-comment/output.js
@@ -0,0 +1,4 @@
+// Make sure not to use a jsx pragma here (like "@jsx Something"), we need this to be React.createElement!
+
+/*#__PURE__*/
+React.createElement("blah", null);