diff --git a/src/errors/Messages.js b/src/errors/Messages.js
index c9d7983fea8a..2b5beaf5c5f9 100644
--- a/src/errors/Messages.js
+++ b/src/errors/Messages.js
@@ -115,6 +115,8 @@ const Messages = {
     "or from a guild's application command manager.",
 
   INTERACTION_ALREADY_REPLIED: 'This interaction has already been deferred or replied to.',
+  INTERACTION_NOT_REPLIED: 'This interaction has not been deferred or replied to.',
+  INTERACTION_EPHEMERAL_REPLIED: 'Ephemeral responses cannot be fetched or deleted.',
 };
 
 for (const [name, message] of Object.entries(Messages)) register(name, message);
diff --git a/src/structures/CommandInteraction.js b/src/structures/CommandInteraction.js
index f5218ccf1bb2..0f4c6672e9c7 100644
--- a/src/structures/CommandInteraction.js
+++ b/src/structures/CommandInteraction.js
@@ -58,6 +58,12 @@ class CommandInteraction extends Interaction {
      */
     this.replied = false;
 
+    /**
+     * Whether the reply to this interaction is ephemeral
+     * @type {?boolean}
+     */
+    this.ephemeral = null;
+
     /**
      * An associated interaction webhook, can be used to further interact with this interaction
      * @type {InteractionWebhook}
diff --git a/src/structures/MessageComponentInteraction.js b/src/structures/MessageComponentInteraction.js
index a0714e1252c0..ffb13caab3a0 100644
--- a/src/structures/MessageComponentInteraction.js
+++ b/src/structures/MessageComponentInteraction.js
@@ -38,6 +38,12 @@ class MessageComponentInteraction extends Interaction {
      */
     this.deferred = false;
 
+    /**
+     * Whether the reply to this interaction is ephemeral
+     * @type {?boolean}
+     */
+    this.ephemeral = null;
+
     /**
      * Whether this interaction has already been replied to
      * @type {boolean}
diff --git a/src/structures/interfaces/InteractionResponses.js b/src/structures/interfaces/InteractionResponses.js
index da23b726eced..ea899a8f68db 100644
--- a/src/structures/interfaces/InteractionResponses.js
+++ b/src/structures/interfaces/InteractionResponses.js
@@ -39,6 +39,7 @@ class InteractionResponses {
    */
   async defer({ ephemeral } = {}) {
     if (this.deferred || this.replied) throw new Error('INTERACTION_ALREADY_REPLIED');
+    this.ephemeral = ephemeral ?? false;
     await this.client.api.interactions(this.id, this.token).callback.post({
       data: {
         type: InteractionResponseTypes.DEFERRED_CHANNEL_MESSAGE_WITH_SOURCE,
@@ -69,6 +70,7 @@ class InteractionResponses {
    */
   async reply(options) {
     if (this.deferred || this.replied) throw new Error('INTERACTION_ALREADY_REPLIED');
+    this.ephemeral = options.ephemeral ?? false;
 
     let apiMessage;
     if (options instanceof APIMessage) apiMessage = options;
@@ -97,6 +99,7 @@ class InteractionResponses {
    *   .catch(console.error);
    */
   fetchReply() {
+    if (this.ephemeral) throw new Error('INTERACTION_EPHEMERAL_REPLIED');
     return this.webhook.fetchMessage('@original');
   }
 
@@ -112,6 +115,7 @@ class InteractionResponses {
    *   .catch(console.error);
    */
   editReply(options) {
+    if (!this.deferred && !this.replied) throw new Error('INTERACTION_NOT_REPLIED');
     return this.webhook.editMessage('@original', options);
   }
 
@@ -126,6 +130,7 @@ class InteractionResponses {
    *   .catch(console.error);
    */
   async deleteReply() {
+    if (this.ephemeral) throw new Error('INTERACTION_EPHEMERAL_REPLIED');
     await this.webhook.deleteMessage('@original');
   }
 
diff --git a/typings/index.d.ts b/typings/index.d.ts
index b6b30b1d5b04..26b1b21b99e1 100644
--- a/typings/index.d.ts
+++ b/typings/index.d.ts
@@ -509,6 +509,7 @@ declare module 'discord.js' {
     public commandID: Snowflake;
     public commandName: string;
     public deferred: boolean;
+    public ephemeral: boolean | null;
     public options: Collection<string, CommandInteractionOption>;
     public replied: boolean;
     public webhook: InteractionWebhook;
@@ -1368,6 +1369,7 @@ declare module 'discord.js' {
     public componentType: MessageComponentType;
     public customID: string;
     public deferred: boolean;
+    public ephemeral: boolean | null;
     public message: Message | RawMessage;
     public replied: boolean;
     public webhook: InteractionWebhook;