diff --git a/src/cli-main.ts b/src/cli-main.ts
index e585fd78..dc17d34f 100644
--- a/src/cli-main.ts
+++ b/src/cli-main.ts
@@ -97,6 +97,9 @@ export async function main(options: Options = {}) {
         const external = ensureArray(flags.external)
         options.external = external
       }
+      if (flags.target) {
+        options.target = flags.target.indexOf(',') >= 0 ? flags.target.split(',') : flags.target
+      }
       if (flags.dts || flags.dtsResolve || flags.dtsOnly) {
         options.dts = {}
         if (typeof flags.dts === 'string') {
diff --git a/src/options.ts b/src/options.ts
index 518061a8..6d9850cd 100644
--- a/src/options.ts
+++ b/src/options.ts
@@ -37,7 +37,7 @@ export type Options = {
    *
    * default to `node12`
    */
-  target?: string
+  target?: string | string[]
   minify?: boolean
   minifyWhitespace?: boolean
   minifyIdentifiers?: boolean
diff --git a/test/index.test.ts b/test/index.test.ts
index 2abe9501..9ac7158b 100644
--- a/test/index.test.ts
+++ b/test/index.test.ts
@@ -760,3 +760,20 @@ test('es5 target', async (t) => {
   t.regex(output, /createClass/)
   t.deepEqual(outFiles, ['input.js'])
 })
+
+test('multiple targets', async (t) => {
+  const { output, outFiles } = await run(
+    t.title,
+    {
+      'input.ts': `
+      export const answer = 42
+      `
+    },
+    {
+      entry: ['input.ts'],
+      flags: ['--target', 'es2020,chrome58,firefox57,safari11,edge16'],
+    }
+  )
+  t.snapshot(output)
+  t.deepEqual(outFiles, ['input.js'])
+})
diff --git a/test/snapshots/index.test.ts.md b/test/snapshots/index.test.ts.md
index 0aadba81..d65e0d6f 100644
--- a/test/snapshots/index.test.ts.md
+++ b/test/snapshots/index.test.ts.md
@@ -41,38 +41,6 @@ Generated by [AVA](https://avajs.dev).
     export { MarkRequired };␊
     `
 
-## es5 target
-
-> Snapshot 1
-
-    `var __defProp = Object.defineProperty;␊
-    var __markAsModule = function (target) { return __defProp(target, "__esModule", { value: true }); };␊
-    var __export = function (target, all) {␊
-      __markAsModule(target);␊
-      for (var name in all)␊
-        { __defProp(target, name, { get: all[name], enumerable: true }); }␊
-    };␊
-    ␊
-    // input.ts␊
-    __export(exports, {␊
-      Foo: function () { return Foo; }␊
-    });␊
-    var Foo = /*@__PURE__*/(function () {␊
-      function Foo () {}␊
-    ␊
-      Foo.prototype.hi = function hi () {␊
-        var a = function () { return "foo"; };␊
-        console.log(a());␊
-      };␊
-    ␊
-      return Foo;␊
-    }());␊
-    // Annotate the CommonJS export names for ESM import in node:␊
-    0 && (module.exports = {␊
-      Foo: Foo␊
-    });␊
-    `
-
 ## multiple formats
 
 > Snapshot 1
@@ -468,3 +436,58 @@ Generated by [AVA](https://avajs.dev).
     ␊
     export { bar };␊
     `
+
+## es5 target
+
+> Snapshot 1
+
+    `var __defProp = Object.defineProperty;␊
+    var __markAsModule = function (target) { return __defProp(target, "__esModule", { value: true }); };␊
+    var __export = function (target, all) {␊
+      __markAsModule(target);␊
+      for (var name in all)␊
+        { __defProp(target, name, { get: all[name], enumerable: true }); }␊
+    };␊
+    ␊
+    // input.ts␊
+    __export(exports, {␊
+      Foo: function () { return Foo; }␊
+    });␊
+    var Foo = /*@__PURE__*/(function () {␊
+      function Foo () {}␊
+    ␊
+      Foo.prototype.hi = function hi () {␊
+        var a = function () { return "foo"; };␊
+        console.log(a());␊
+      };␊
+    ␊
+      return Foo;␊
+    }());␊
+    // Annotate the CommonJS export names for ESM import in node:␊
+    0 && (module.exports = {␊
+      Foo: Foo␊
+    });␊
+    `
+
+## multiple targets
+
+> Snapshot 1
+
+    `var __defProp = Object.defineProperty;␊
+    var __markAsModule = (target) => __defProp(target, "__esModule", { value: true });␊
+    var __export = (target, all) => {␊
+      __markAsModule(target);␊
+      for (var name in all)␊
+        __defProp(target, name, { get: all[name], enumerable: true });␊
+    };␊
+    ␊
+    // input.ts␊
+    __export(exports, {␊
+      answer: () => answer␊
+    });␊
+    var answer = 42;␊
+    // Annotate the CommonJS export names for ESM import in node:␊
+    0 && (module.exports = {␊
+      answer␊
+    });␊
+    `
diff --git a/test/snapshots/index.test.ts.snap b/test/snapshots/index.test.ts.snap
index e622ded7..e4d2e82f 100644
Binary files a/test/snapshots/index.test.ts.snap and b/test/snapshots/index.test.ts.snap differ