diff --git a/shell/browser/electron_permission_manager.cc b/shell/browser/electron_permission_manager.cc
index 6970369b80432..5e37cfb92b68a 100644
--- a/shell/browser/electron_permission_manager.cc
+++ b/shell/browser/electron_permission_manager.cc
@@ -339,18 +339,25 @@ bool ElectronPermissionManager::CheckDevicePermission(
               granted_device.FindStringKey(kDeviceInstanceIdKey))
             return true;
 #else
+          const auto* serial_number =
+              granted_device.FindStringKey(kSerialNumberKey);
+          const auto* port_serial_number =
+              device->FindStringKey(kSerialNumberKey);
           if (device->FindIntKey(kVendorIdKey) !=
                   granted_device.FindIntKey(kVendorIdKey) ||
               device->FindIntKey(kProductIdKey) !=
                   granted_device.FindIntKey(kProductIdKey) ||
-              *device->FindStringKey(kSerialNumberKey) !=
-                  *granted_device.FindStringKey(kSerialNumberKey)) {
+              (serial_number && port_serial_number &&
+               *port_serial_number != *serial_number)) {
             continue;
           }
 
 #if BUILDFLAG(IS_MAC)
-          if (*device->FindStringKey(kUsbDriverKey) !=
-              *granted_device.FindStringKey(kUsbDriverKey)) {
+          const auto* usb_driver_key = device->FindStringKey(kUsbDriverKey);
+          const auto* port_usb_driver_key =
+              granted_device.FindStringKey(kUsbDriverKey);
+          if (usb_driver_key && port_usb_driver_key &&
+              *usb_driver_key != *port_usb_driver_key) {
             continue;
           }
 #endif  // BUILDFLAG(IS_MAC)
diff --git a/spec-main/chromium-spec.ts b/spec-main/chromium-spec.ts
index ca93d5e0954bd..244b5b5e5ecd0 100644
--- a/spec-main/chromium-spec.ts
+++ b/spec-main/chromium-spec.ts
@@ -1684,6 +1684,24 @@ describe('navigator.serial', () => {
     const port = await getPorts();
     expect(port).to.equal('[object SerialPort]');
   });
+
+  it('navigator.serial.getPorts() returns values', async () => {
+    let havePorts = false;
+
+    w.webContents.session.on('select-serial-port', (event, portList, webContents, callback) => {
+      if (portList.length > 0) {
+        havePorts = true;
+        callback(portList[0].portId);
+      } else {
+        callback('');
+      }
+    });
+    await getPorts();
+    if (havePorts) {
+      const grantedPorts = await w.webContents.executeJavaScript('navigator.serial.getPorts()');
+      expect(grantedPorts).to.not.be.empty();
+    }
+  });
 });
 
 describe('navigator.clipboard', () => {
@@ -2005,7 +2023,6 @@ describe('navigator.hid', () => {
       if (details.deviceList.length > 0) {
         details.deviceList.find((device) => {
           if (device.name && device.name !== '' && device.serialNumber && device.serialNumber !== '') {
-            console.log('device is: ', device);
             if (checkForExcludedDevice) {
               const compareDevice = {
                 vendorId: device.vendorId,