diff --git a/.github/workflows/e2e.yml b/.github/workflows/e2e.yml
index db36a7a001b..7d6c9a8021c 100644
--- a/.github/workflows/e2e.yml
+++ b/.github/workflows/e2e.yml
@@ -19,6 +19,13 @@ jobs:
         with:
           node-version: 16
 
+      # The version of Deno is pinned because version 1.25.1 was causing test
+      # flakes due to random segfaults.
+      - name: Setup Deno 1.24.0
+        uses: denoland/setup-deno@main
+        with:
+          deno-version: v1.24.0
+
       - name: Test npm
         run: |
           npm i -g npm@next-7
@@ -33,3 +40,7 @@ jobs:
         run: |
           npm i -g yarn@latest
           time make test-e2e-yarn-berry
+
+      - name: Test deno
+        run: |
+          time make test-e2e-deno
diff --git a/Makefile b/Makefile
index 9ce2ae350b7..37d3f133b8c 100644
--- a/Makefile
+++ b/Makefile
@@ -100,7 +100,7 @@ lib-typecheck: | lib/node_modules
 	cd lib && node_modules/.bin/tsc -noEmit -p tsconfig-deno.json
 
 # End-to-end tests
-test-e2e: test-e2e-npm test-e2e-pnpm test-e2e-yarn-berry
+test-e2e: test-e2e-npm test-e2e-pnpm test-e2e-yarn-berry test-e2e-deno
 
 test-e2e-npm:
 	# Test normal install
@@ -204,6 +204,9 @@ test-e2e-yarn-berry:
 	# Clean up
 	rm -fr e2e-yb
 
+test-e2e-deno:
+	deno eval 'import { transform, stop } from "https://deno.land/x/esbuild@v$(ESBUILD_VERSION)/mod.js"; console.log((await transform("1+2")).code); stop()' | grep "1 + 2;"
+
 test-yarnpnp: platform-wasm
 	node scripts/test-yarnpnp.js