diff --git a/README.md b/README.md
index c528fdb13..52d79f4a3 100644
--- a/README.md
+++ b/README.md
@@ -2011,6 +2011,19 @@ const config = {
 // Options: ["always"]
 // Message: Expected JSDoc block lines to be aligned.
 
+/**
+ * My object.
+ *
+ * @typedef {Object} MyObject
+ *
+ * @property {{a: number, b: string, c}} lorem Description.
+ * @property {Object.<string, Class>} sit Description multi words.
+ * @property {Object.<string, Class>} amet Description} weird {multi} {{words}}.
+ * @property {Object.<string, Class>} dolor
+ */
+// Options: ["always"]
+// Message: Expected JSDoc block lines to be aligned.
+
 /**
  * Not implemented yet.
  *
@@ -2128,6 +2141,22 @@ const config = {
  */
 // Options: ["always"]
 
+/**
+ * My object.
+ *
+ * @typedef {Object} MyObject
+ *
+ * @property {{a: number, b: string, c}} lorem Description.
+ * @property {Object.<string, Class>}    sit   Description multi words.
+ * @property {Object.<string, Class>}    amet  Description} weird {multi} {{words}}.
+ * @property {Object.<string, Class>}    dolor
+ */
+// Options: ["always"]
+
+/** @param {number} lorem */
+const fn = ( lorem ) => {}
+// Options: ["always"]
+
 /**
  * Not validating without option.
  *
diff --git a/src/rules/checkLineAlignment.js b/src/rules/checkLineAlignment.js
index 0d451bc23..318b1a168 100644
--- a/src/rules/checkLineAlignment.js
+++ b/src/rules/checkLineAlignment.js
@@ -31,7 +31,7 @@ const matchAll = (string, regexp, callback, limit) => {
  * @returns {string} The full description.
  */
 const getFullDescription = (lineString) => {
-  return /(?:\S+\s+){4}(.*)/.exec(lineString)[1];
+  return /\S+\s+(?:{{.*?}}|{.*?})\s+\S+\s+(.*)/.exec(lineString)[1];
 };
 
 /**
@@ -139,7 +139,7 @@ const checkCommentPerTag = (comment, tag, tagIndentation, report) => {
     // All line parts until the first word of the description (if description exists).
     matchAll(
       lineString,
-      /\S+/g,
+      /{{.*?}}|{.*?}|\S+/g,
       ({0: match, index: position}, partIndex) => {
         set(partsMatrix, [lineIndex, partIndex], {
           position,
@@ -187,6 +187,11 @@ export default iterateJsdoc(({
     return;
   }
 
+  // Skip if it contains only a single line.
+  if (!jsdocNode.value.includes('\n')) {
+    return;
+  }
+
   // `indent` is whitespace from line 1 (`/**`), so slice and account for "/".
   const tagIndentation = indent + ' ';
 
diff --git a/test/rules/assertions/checkLineAlignment.js b/test/rules/assertions/checkLineAlignment.js
index b58917690..ea8f391de 100644
--- a/test/rules/assertions/checkLineAlignment.js
+++ b/test/rules/assertions/checkLineAlignment.js
@@ -364,6 +364,41 @@ export default {
          */
       `,
     },
+    {
+      code: `
+        /**
+         * My object.
+         *
+         * @typedef {Object} MyObject
+         *
+         * @property {{a: number, b: string, c}} lorem Description.
+         * @property {Object.<string, Class>} sit Description multi words.
+         * @property {Object.<string, Class>} amet Description} weird {multi} {{words}}.
+         * @property {Object.<string, Class>} dolor
+         */
+      `,
+      errors: [
+        {
+          message: 'Expected JSDoc block lines to be aligned.',
+          type: 'Block',
+        },
+      ],
+      options: [
+        'always',
+      ],
+      output: `
+        /**
+         * My object.
+         *
+         * @typedef {Object} MyObject
+         *
+         * @property {{a: number, b: string, c}} lorem Description.
+         * @property {Object.<string, Class>}    sit   Description multi words.
+         * @property {Object.<string, Class>}    amet  Description} weird {multi} {{words}}.
+         * @property {Object.<string, Class>}    dolor
+         */
+      `,
+    },
     {
       code: `
         /**
@@ -549,6 +584,32 @@ export default {
         'always',
       ],
     },
+    {
+      code: `
+        /**
+         * My object.
+         *
+         * @typedef {Object} MyObject
+         *
+         * @property {{a: number, b: string, c}} lorem Description.
+         * @property {Object.<string, Class>}    sit   Description multi words.
+         * @property {Object.<string, Class>}    amet  Description} weird {multi} {{words}}.
+         * @property {Object.<string, Class>}    dolor
+         */
+      `,
+      options: [
+        'always',
+      ],
+    },
+    {
+      code: `
+        /** @param {number} lorem */
+        const fn = ( lorem ) => {}
+      `,
+      options: [
+        'always',
+      ],
+    },
     {
       code: `
         /**