diff --git a/google/cloud/lifesciences/v2beta/BUILD.bazel b/google/cloud/lifesciences/v2beta/BUILD.bazel
index bc89affe55f27..567bf9abb7dd3 100644
--- a/google/cloud/lifesciences/v2beta/BUILD.bazel
+++ b/google/cloud/lifesciences/v2beta/BUILD.bazel
@@ -39,6 +39,7 @@ proto_library_with_info(
     deps = [
         ":lifesciences_proto",
         "//google/cloud:common_resources_proto",
+        "//google/cloud/location:location_proto",
     ],
 )
 
@@ -68,14 +69,19 @@ java_grpc_library(
 java_gapic_library(
     name = "lifesciences_java_gapic",
     srcs = [":lifesciences_proto_with_info"],
+    gapic_yaml = None,
     grpc_service_config = "lifesciences_grpc_service_config.json",
     rest_numeric_enums = False,
+    service_yaml = "lifesciences_v2beta.yaml",
     test_deps = [
         ":lifesciences_java_grpc",
+        "//google/cloud/location:location_java_grpc",
     ],
     transport = "grpc+rest",
     deps = [
         ":lifesciences_java_proto",
+        "//google/api:api_java_proto",
+        "//google/cloud/location:location_java_proto",
     ],
 )
 
@@ -135,6 +141,7 @@ go_gapic_library(
     transport = "grpc+rest",
     deps = [
         ":lifesciences_go_proto",
+        "//google/cloud/location:location_go_proto",
         "//google/longrunning:longrunning_go_proto",
         "@com_google_cloud_go//longrunning:go_default_library",
         "@com_google_cloud_go//longrunning/autogen:go_default_library",
@@ -176,7 +183,10 @@ py_gapic_library(
     grpc_service_config = "lifesciences_grpc_service_config.json",
     opt_args = ["warehouse-package-name=google-cloud-life-sciences"],
     rest_numeric_enums = False,
+    service_yaml = "lifesciences_v2beta.yaml",
     transport = "grpc+rest",
+    deps = [
+    ],
 )
 
 py_test(
@@ -298,17 +308,18 @@ ruby_cloud_gapic_library(
     name = "lifesciences_ruby_gapic",
     srcs = [":lifesciences_proto_with_info"],
     extra_protoc_parameters = [
-        "ruby-cloud-gem-name=google-cloud-life_sciences-v2beta",
-        "ruby-cloud-env-prefix=LIFE_SCIENCES",
-        "ruby-cloud-product-url=https://cloud.google.com/life-sciences/",
         "ruby-cloud-api-id=lifesciences.googleapis.com",
         "ruby-cloud-api-shortname=lifesciences",
+        "ruby-cloud-env-prefix=LIFE_SCIENCES",
+        "ruby-cloud-gem-name=google-cloud-life_sciences-v2beta",
+        "ruby-cloud-product-url=https://cloud.google.com/life-sciences/",
         "ruby-cloud-service-override=WorkflowsServiceV2Beta=WorkflowsService",
     ],
     grpc_service_config = "lifesciences_grpc_service_config.json",
     rest_numeric_enums = False,
     ruby_cloud_description = "Cloud Life Sciences is a suite of services and tools for managing, processing, and transforming life sciences data. It also enables advanced insights and operational workflows using highly scalable and compliant infrastructure.",
     ruby_cloud_title = "Cloud Life Sciences V2beta",
+    service_yaml = "lifesciences_v2beta.yaml",
     deps = [
         ":lifesciences_ruby_grpc",
         ":lifesciences_ruby_proto",
@@ -373,4 +384,20 @@ csharp_gapic_assembly_pkg(
 ##############################################################################
 # C++
 ##############################################################################
-# Put your C++ rules here
+load(
+    "@com_google_googleapis_imports//:imports.bzl",
+    "cc_grpc_library",
+    "cc_proto_library",
+)
+
+cc_proto_library(
+    name = "lifesciences_cc_proto",
+    deps = [":lifesciences_proto"],
+)
+
+cc_grpc_library(
+    name = "lifesciences_cc_grpc",
+    srcs = [":lifesciences_proto"],
+    grpc_only = True,
+    deps = [":lifesciences_cc_proto"],
+)
diff --git a/google/cloud/lifesciences/v2beta/lifesciences_v2beta.yaml b/google/cloud/lifesciences/v2beta/lifesciences_v2beta.yaml
index c3b14c1a70639..5f0c0f9841f85 100644
--- a/google/cloud/lifesciences/v2beta/lifesciences_v2beta.yaml
+++ b/google/cloud/lifesciences/v2beta/lifesciences_v2beta.yaml
@@ -5,6 +5,8 @@ title: Cloud Life Sciences API
 
 apis:
 - name: google.cloud.lifesciences.v2beta.WorkflowsServiceV2Beta
+- name: google.cloud.location.Locations
+- name: google.longrunning.Operations
 
 types:
 - name: google.cloud.lifesciences.v2beta.ContainerKilledEvent
diff --git a/google/cloud/lifesciences/v2beta/workflows.proto b/google/cloud/lifesciences/v2beta/workflows.proto
index b69928ffa8f41..2e9c576c63f55 100644
--- a/google/cloud/lifesciences/v2beta/workflows.proto
+++ b/google/cloud/lifesciences/v2beta/workflows.proto
@@ -1,4 +1,4 @@
-// Copyright 2021 Google LLC
+// Copyright 2022 Google LLC
 //
 // Licensed under the Apache License, Version 2.0 (the "License");
 // you may not use this file except in compliance with the License.
@@ -17,12 +17,12 @@ syntax = "proto3";
 package google.cloud.lifesciences.v2beta;
 
 import "google/api/annotations.proto";
+import "google/api/client.proto";
 import "google/api/field_behavior.proto";
 import "google/longrunning/operations.proto";
 import "google/protobuf/duration.proto";
 import "google/protobuf/timestamp.proto";
 import "google/rpc/code.proto";
-import "google/api/client.proto";
 
 option csharp_namespace = "Google.Cloud.LifeSciences.V2Beta";
 option go_package = "google.golang.org/genproto/googleapis/cloud/lifesciences/v2beta;lifesciences";
@@ -112,6 +112,15 @@ message Pipeline {
   // (though they can overwrite it with a different value).
   map<string, string> environment = 3;
 
+  // The encrypted environment to pass into every action. Each action can also
+  // specify its own encrypted environment.
+  //
+  // The secret must decrypt to a JSON-encoded dictionary where key-value pairs
+  // serve as environment variable names and their values. The decoded
+  // environment variables can overwrite the values specified by the
+  // `environment` field.
+  Secret encrypted_environment = 5;
+
   // The maximum amount of time to give the pipeline to complete.  This includes
   // the time spent waiting for a worker to be allocated.  If the pipeline fails
   // to complete before the timeout, it will be cancelled and the error code
@@ -172,6 +181,17 @@ message Action {
   // authors to determine whether an individual action has succeeded or failed.
   map<string, string> environment = 5;
 
+  // The encrypted environment to pass into the container. This environment is
+  // merged with values specified in the
+  // [google.cloud.lifesciences.v2beta.Pipeline][google.cloud.lifesciences.v2beta.Pipeline] message, overwriting any
+  // duplicate values.
+  //
+  // The secret must decrypt to a JSON-encoded dictionary where key-value pairs
+  // serve as environment variable names and their values. The decoded
+  // environment variables can overwrite the values specified by the
+  // `environment` field.
+  Secret encrypted_environment = 21;
+
   // An optional identifier for a PID namespace to run the action inside.
   // Multiple actions should use the same string to share a namespace.  If
   // unspecified, a separate isolated namespace is used.
@@ -408,6 +428,10 @@ message VirtualMachine {
   //
   // Specify either the `volumes[]` field or the `disks[]` field, but not both.
   repeated Volume volumes = 14;
+
+  // If specified, the VM will only be allocated inside the matching
+  // reservation. It will fail if the VM parameters don't match the reservation.
+  string reservation = 15;
 }
 
 // Carries information about a Google Cloud service account.