diff --git a/.github/.OwlBot.lock.yaml b/.github/.OwlBot.lock.yaml
index 757c9dc..1ce6085 100644
--- a/.github/.OwlBot.lock.yaml
+++ b/.github/.OwlBot.lock.yaml
@@ -13,5 +13,5 @@
 # limitations under the License.
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-python:latest
-  digest: sha256:81ed5ecdfc7cac5b699ba4537376f3563f6f04122c4ec9e735d3b3dc1d43dd32
-# created: 2022-05-05T22:08:23.383410683Z
+  digest: sha256:e7bb19d47c13839fe8c147e50e02e8b6cf5da8edd1af8b82208cd6f66cc2829c
+# created: 2022-07-05T18:31:20.838186805Z
diff --git a/.github/sync-repo-settings.yaml b/.github/sync-repo-settings.yaml
index 19f4daa..445e64c 100644
--- a/.github/sync-repo-settings.yaml
+++ b/.github/sync-repo-settings.yaml
@@ -11,7 +11,6 @@ branchProtectionRules:
     # No Kokoro:  the following are Github actions
     - 'mypy'
     - 'lint'
-    - 'unit (3.6)'
     - 'unit (3.7)'
     - 'unit (3.8)'
     - 'unit (3.9)'
diff --git a/.github/workflows/unittest.yml b/.github/workflows/unittest.yml
index e5be6ed..5531b01 100644
--- a/.github/workflows/unittest.yml
+++ b/.github/workflows/unittest.yml
@@ -8,7 +8,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python: ['3.6', '3.7', '3.8', '3.9', '3.10']
+        python: ['3.7', '3.8', '3.9', '3.10']
     steps:
     - name: Checkout
       uses: actions/checkout@v3
diff --git a/.kokoro/continuous/prerelease-deps.cfg b/.kokoro/continuous/prerelease-deps.cfg
new file mode 100644
index 0000000..3595fb4
--- /dev/null
+++ b/.kokoro/continuous/prerelease-deps.cfg
@@ -0,0 +1,7 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+# Only run this nox session.
+env_vars: {
+    key: "NOX_SESSION"
+    value: "prerelease_deps"
+}
diff --git a/.kokoro/presubmit/prerelease-deps.cfg b/.kokoro/presubmit/prerelease-deps.cfg
new file mode 100644
index 0000000..3595fb4
--- /dev/null
+++ b/.kokoro/presubmit/prerelease-deps.cfg
@@ -0,0 +1,7 @@
+# Format: //devtools/kokoro/config/proto/build.proto
+
+# Only run this nox session.
+env_vars: {
+    key: "NOX_SESSION"
+    value: "prerelease_deps"
+}
diff --git a/.kokoro/samples/python3.6/common.cfg b/.kokoro/samples/python3.6/common.cfg
deleted file mode 100644
index 276a53f..0000000
--- a/.kokoro/samples/python3.6/common.cfg
+++ /dev/null
@@ -1,40 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-# Build logs will be here
-action {
-  define_artifacts {
-    regex: "**/*sponge_log.xml"
-  }
-}
-
-# Specify which tests to run
-env_vars: {
-    key: "RUN_TESTS_SESSION"
-    value: "py-3.6"
-}
-
-# Declare build specific Cloud project.
-env_vars: {
-    key: "BUILD_SPECIFIC_GCLOUD_PROJECT"
-    value: "python-docs-samples-tests-py36"
-}
-
-env_vars: {
-    key: "TRAMPOLINE_BUILD_FILE"
-    value: "github/python-cloud-core/.kokoro/test-samples.sh"
-}
-
-# Configure the docker image for kokoro-trampoline.
-env_vars: {
-    key: "TRAMPOLINE_IMAGE"
-    value: "gcr.io/cloud-devrel-kokoro-resources/python-samples-testing-docker"
-}
-
-# Download secrets for samples
-gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/python-docs-samples"
-
-# Download trampoline resources.
-gfile_resources: "/bigstore/cloud-devrel-kokoro-resources/trampoline"
-
-# Use the trampoline script to run in docker.
-build_file: "python-cloud-core/.kokoro/trampoline_v2.sh"
\ No newline at end of file
diff --git a/.kokoro/samples/python3.6/continuous.cfg b/.kokoro/samples/python3.6/continuous.cfg
deleted file mode 100644
index 7218af1..0000000
--- a/.kokoro/samples/python3.6/continuous.cfg
+++ /dev/null
@@ -1,7 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
-
diff --git a/.kokoro/samples/python3.6/periodic-head.cfg b/.kokoro/samples/python3.6/periodic-head.cfg
deleted file mode 100644
index f9e9e94..0000000
--- a/.kokoro/samples/python3.6/periodic-head.cfg
+++ /dev/null
@@ -1,11 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
-
-env_vars: {
-    key: "TRAMPOLINE_BUILD_FILE"
-    value: "github/python-cloud-core/.kokoro/test-samples-against-head.sh"
-}
diff --git a/.kokoro/samples/python3.6/periodic.cfg b/.kokoro/samples/python3.6/periodic.cfg
deleted file mode 100644
index 71cd1e5..0000000
--- a/.kokoro/samples/python3.6/periodic.cfg
+++ /dev/null
@@ -1,6 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "False"
-}
diff --git a/.kokoro/samples/python3.6/presubmit.cfg b/.kokoro/samples/python3.6/presubmit.cfg
deleted file mode 100644
index a1c8d97..0000000
--- a/.kokoro/samples/python3.6/presubmit.cfg
+++ /dev/null
@@ -1,6 +0,0 @@
-# Format: //devtools/kokoro/config/proto/build.proto
-
-env_vars: {
-    key: "INSTALL_LIBRARY_FROM_SOURCE"
-    value: "True"
-}
\ No newline at end of file
diff --git a/.kokoro/test-samples-impl.sh b/.kokoro/test-samples-impl.sh
index 8a324c9..2c6500c 100755
--- a/.kokoro/test-samples-impl.sh
+++ b/.kokoro/test-samples-impl.sh
@@ -33,7 +33,7 @@ export PYTHONUNBUFFERED=1
 env | grep KOKORO
 
 # Install nox
-python3.6 -m pip install --upgrade --quiet nox
+python3.9 -m pip install --upgrade --quiet nox
 
 # Use secrets acessor service account to get secrets
 if [[ -f "${KOKORO_GFILE_DIR}/secrets_viewer_service_account.json" ]]; then
@@ -76,7 +76,7 @@ for file in samples/**/requirements.txt; do
     echo "------------------------------------------------------------"
 
     # Use nox to execute the tests for the project.
-    python3.6 -m nox -s "$RUN_TESTS_SESSION"
+    python3.9 -m nox -s "$RUN_TESTS_SESSION"
     EXIT=$?
 
     # If this is a periodic build, send the test log to the FlakyBot.
diff --git a/CONTRIBUTING.rst b/CONTRIBUTING.rst
index 73c2ae2..1cfccd9 100644
--- a/CONTRIBUTING.rst
+++ b/CONTRIBUTING.rst
@@ -22,7 +22,7 @@ In order to add a feature:
   documentation.
 
 - The feature must work fully on the following CPython versions:
-  3.6, 3.7, 3.8, 3.9 and 3.10 on both UNIX and Windows.
+  3.7, 3.8, 3.9 and 3.10 on both UNIX and Windows.
 
 - The feature must not add unnecessary dependencies (where
   "unnecessary" is of course subjective, but new dependencies should
@@ -221,13 +221,11 @@ Supported Python Versions
 
 We support:
 
--  `Python 3.6`_
 -  `Python 3.7`_
 -  `Python 3.8`_
 -  `Python 3.9`_
 -  `Python 3.10`_
 
-.. _Python 3.6: https://docs.python.org/3.6/
 .. _Python 3.7: https://docs.python.org/3.7/
 .. _Python 3.8: https://docs.python.org/3.8/
 .. _Python 3.9: https://docs.python.org/3.9/
@@ -239,7 +237,7 @@ Supported versions can be found in our ``noxfile.py`` `config`_.
 .. _config: https://github.com/googleapis/python-cloud-core/blob/main/noxfile.py
 
 
-We also explicitly decided to support Python 3 beginning with version 3.6.
+We also explicitly decided to support Python 3 beginning with version 3.7.
 Reasons for this include:
 
 -  Encouraging use of newest versions of Python 3
diff --git a/README.rst b/README.rst
index ab2f629..4a3b2b3 100644
--- a/README.rst
+++ b/README.rst
@@ -32,9 +32,12 @@ to `Python Development Environment Setup Guide`_ for Google Cloud Platform.
 
 Supported Python Versions
 -------------------------
-Python >= 3.6
+Python >= 3.7
 
 Unsupported Python Versions
 ---------------------------
 Python == 2.7: the last version of this library which supported Python 2.7
 is ``google.cloud.core 1.7.2``.
+
+Python == 3.6: the last version of this library which supported Python 3.6
+is ``google.cloud.core 2.3.1``.
diff --git a/owlbot.py b/owlbot.py
index 49c6c49..1006250 100644
--- a/owlbot.py
+++ b/owlbot.py
@@ -26,7 +26,6 @@
 templated_files = common.py_library(
     microgenerator=True,
     cov_level=100,
-    unit_test_python_versions=["3.6", "3.7", "3.8", "3.9", "3.10"],
 )
 s.move(
     templated_files,
@@ -36,6 +35,7 @@
         ".flake8",
         ".coveragerc",
         "setup.cfg",
+	"README.rst",
     ],
 )
 
diff --git a/scripts/readme-gen/templates/install_deps.tmpl.rst b/scripts/readme-gen/templates/install_deps.tmpl.rst
index 275d649..6f069c6 100644
--- a/scripts/readme-gen/templates/install_deps.tmpl.rst
+++ b/scripts/readme-gen/templates/install_deps.tmpl.rst
@@ -12,7 +12,7 @@ Install Dependencies
    .. _Python Development Environment Setup Guide:
        https://cloud.google.com/python/setup
 
-#. Create a virtualenv. Samples are compatible with Python 3.6+.
+#. Create a virtualenv. Samples are compatible with Python 3.7+.
 
     .. code-block:: bash
 
diff --git a/setup.py b/setup.py
index 55100a3..06852b8 100644
--- a/setup.py
+++ b/setup.py
@@ -28,10 +28,10 @@
 # 'Development Status :: 5 - Production/Stable'
 release_status = "Development Status :: 5 - Production/Stable"
 dependencies = [
-    "google-api-core >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
+    "google-api-core >= 1.31.6, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
     "google-auth >= 1.25.0, < 3.0dev",
 ]
-extras = {"grpc": "grpcio >= 1.8.2, < 2.0dev"}
+extras = {"grpc": "grpcio >= 1.38.0, < 2.0dev"}
 
 
 # Setup boilerplate below this line.
@@ -74,7 +74,6 @@
         "License :: OSI Approved :: Apache Software License",
         "Programming Language :: Python",
         "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
@@ -87,7 +86,7 @@
     namespace_packages=namespaces,
     install_requires=dependencies,
     extras_require=extras,
-    python_requires=">=3.6",
+    python_requires=">=3.7",
     include_package_data=True,
     zip_safe=False,
 )
diff --git a/testing/constraints-3.6.txt b/testing/constraints-3.6.txt
deleted file mode 100644
index 8b2701c..0000000
--- a/testing/constraints-3.6.txt
+++ /dev/null
@@ -1,10 +0,0 @@
-# This constraints file is used to check that lower bounds
-# are correct in setup.py
-# List *all* library dependencies and extras in this file.
-# Pin the version to the lower bound.
-#
-# e.g., if setup.py has "foo >= 1.14.0, < 2.0.0dev",
-# Then this file should have foo==1.14.0
-google-api-core==1.31.5
-google-auth==1.25.0
-grpcio==1.8.2
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index e69de29..2964afa 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -0,0 +1,10 @@
+# This constraints file is used to check that lower bounds
+# are correct in setup.py
+# List *all* library dependencies and extras in this file.
+# Pin the version to the lower bound.
+#
+# e.g., if setup.py has "foo >= 1.14.0, < 2.0.0dev",
+# Then this file should have foo==1.14.0
+google-api-core==1.31.6
+google-auth==1.25.0
+grpcio==1.38.0