HiC maps and TADs don't match with chromsizes

[Naveen-Ahuja]

Hi,

When I try to add a different assembly when ingesting a .mcool there is no difference in the hic maps

Also my hic matrices were made with hg38(I didn't make them from scratch they were given to me but I checked with the person who made it) but when I plot my TADs (using SpectralTAD) they don't line up. Only when I aggregate the bedpe file with hg19 it aligns with my hic matrices. This is doesn't make sense to me, do you have any idea as to why this may be happening?

Steps to reproduce

1. higlass-manage ingest Control_P7_10Kb_ice.mcool --assembly hg19 --chromsizes-filename hg19.chrom.sizes.tsv
2. Control_P7_10Kb_ice.mcool --assembly hg38 --chromsizes-filename hg38.chrom.sizes.tsv
3. clodius aggregate bedpe
   --assembly hg19
   --chr1-col 1 --from1-col 2 --to1-col 3
   --chr2-col 4 --from2-col 5 --to2-col 6
   --output-file C_ice_P7_chr4_50Kb.bedpe.txt.multires
   C_ice_P7_chr4_50Kb.bedpe

Observed behavior

Thank you