diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4fb9c5886151..828a9175cba3 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -6,6 +6,7 @@
 
 - `[@jest/types]` Mark deprecated configuration options as `@deprecated` ([#11913](https://github.com/facebook/jest/pull/11913))
 - `[jest-cli]` Improve `--help` printout by removing defunct `--browser` option ([#11914](https://github.com/facebook/jest/pull/11914))
+- `[jest-haste-map]` Use distinct cache paths for different values of `computeDependencies` ([#11916](https://github.com/facebook/jest/pull/11916))
 
 ### Chore & Maintenance
 
diff --git a/packages/jest-haste-map/src/__tests__/index.test.js b/packages/jest-haste-map/src/__tests__/index.test.js
index c95ed070998f..90ca7dccf774 100644
--- a/packages/jest-haste-map/src/__tests__/index.test.js
+++ b/packages/jest-haste-map/src/__tests__/index.test.js
@@ -265,6 +265,20 @@ describe('HasteMap', () => {
     expect(hasteMap1.getCacheFilePath()).not.toBe(hasteMap2.getCacheFilePath());
   });
 
+  it('creates different cache file paths for different values of computeDependencies', () => {
+    jest.resetModules();
+    const HasteMap = require('../').default;
+    const hasteMap1 = new HasteMap({
+      ...defaultConfig,
+      computeDependencies: true,
+    });
+    const hasteMap2 = new HasteMap({
+      ...defaultConfig,
+      computeDependencies: false,
+    });
+    expect(hasteMap1.getCacheFilePath()).not.toBe(hasteMap2.getCacheFilePath());
+  });
+
   it('creates different cache file paths for different hasteImplModulePath cache keys', () => {
     jest.resetModules();
     const HasteMap = require('../').default;
diff --git a/packages/jest-haste-map/src/index.ts b/packages/jest-haste-map/src/index.ts
index 213e623a4cfe..760f2a975afa 100644
--- a/packages/jest-haste-map/src/index.ts
+++ b/packages/jest-haste-map/src/index.ts
@@ -325,6 +325,7 @@ export default class HasteMap extends EventEmitter {
       (options.ignorePattern || '').toString(),
       hasteImplHash,
       dependencyExtractorHash,
+      this._options.computeDependencies.toString(),
     );
     this._buildPromise = null;
     this._watchers = [];