diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2cdded6df47d..09a785d68a7a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,8 @@
 
 ### Fixes
 
+- `[jest-environment-node]` Add `atob` and `btoa` ([#12269](https://github.com/facebook/jest/pull/12269))
+
 ### Chore & Maintenance
 
 - `[*]` Update graceful-fs to ^4.2.9 ([#11749](https://github.com/facebook/jest/pull/11749))
diff --git a/packages/jest-environment-node/src/index.ts b/packages/jest-environment-node/src/index.ts
index 385821e810d4..27b65b5add37 100644
--- a/packages/jest-environment-node/src/index.ts
+++ b/packages/jest-environment-node/src/index.ts
@@ -82,6 +82,11 @@ class NodeEnvironment implements JestEnvironment<Timer> {
     if (typeof performance !== 'undefined') {
       global.performance = performance;
     }
+    // atob and btoa are global in Node >= 16
+    if (typeof atob !== 'undefined' && typeof btoa !== 'undefined') {
+      global.atob = atob;
+      global.btoa = btoa;
+    }
     installCommonGlobals(global, config.globals);
 
     this.moduleMocker = new ModuleMocker(global);