diff --git a/CHANGELOG.md b/CHANGELOG.md
index 051e7bf00cc1..0bd042036a3b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -32,6 +32,7 @@
 - `[jest-jasmine2]`: Throw explicit error when errors happen after test is considered complete ([#8005](https://github.com/facebook/jest/pull/8005))
 - `[jest-circus]`: Throw explicit error when errors happen after test is considered complete ([#8005](https://github.com/facebook/jest/pull/8005))
 - `[expect]` Remove duck typing and obsolete browser support code when comparing DOM nodes and use DOM-Level-3 API instead ([#7995](https://github.com/facebook/jest/pull/7995))
+- `[jest-mock]` Adds a type check to `prototype` to allow mocks of objects with a primitive `prototype` property. ([#8040](https://github.com/facebook/jest/pull/8040))
 
 ### Chore & Maintenance
 
diff --git a/packages/jest-mock/src/__tests__/index.test.ts b/packages/jest-mock/src/__tests__/index.test.ts
index 31cee40614c8..bd0d57f50746 100644
--- a/packages/jest-mock/src/__tests__/index.test.ts
+++ b/packages/jest-mock/src/__tests__/index.test.ts
@@ -6,18 +6,18 @@
  *
  */
 
-import vm from 'vm';
+import vm, {Context} from 'vm';
+import {ModuleMocker} from '../';
 
 describe('moduleMocker', () => {
-  let moduleMocker;
-  let mockContext;
-  let mockGlobals;
+  let moduleMocker: ModuleMocker;
+  let mockContext: Context;
+  let mockGlobals: NodeJS.Global;
 
   beforeEach(() => {
-    const mock = require('../');
     mockContext = vm.createContext();
     mockGlobals = vm.runInNewContext('this', mockContext);
-    moduleMocker = new mock.ModuleMocker(mockGlobals);
+    moduleMocker = new ModuleMocker(mockGlobals);
   });
 
   describe('getMetadata', () => {
@@ -880,6 +880,14 @@ describe('moduleMocker', () => {
         expect(fn1()).toEqual('abcd');
         expect(fn2()).toEqual('abcde');
       });
+
+      it('handles a property called `prototype`', () => {
+        const mock = moduleMocker.generateFromMetadata(
+          moduleMocker.getMetadata({prototype: 1}),
+        );
+
+        expect(mock.prototype).toBe(1);
+      });
     });
   });
 
diff --git a/packages/jest-mock/src/index.ts b/packages/jest-mock/src/index.ts
index b39c2b9f7ed9..26c2a53d6359 100644
--- a/packages/jest-mock/src/index.ts
+++ b/packages/jest-mock/src/index.ts
@@ -844,7 +844,8 @@ class ModuleMockerClass {
     if (
       metadata.type !== 'undefined' &&
       metadata.type !== 'null' &&
-      mock.prototype
+      mock.prototype &&
+      typeof mock.prototype === 'object'
     ) {
       mock.prototype.constructor = mock;
     }