diff --git a/CHANGELOG.md b/CHANGELOG.md
index 07c630555d7e..30e02ef4c957 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -21,6 +21,7 @@
 
 - `[jest-resolve]` Update `resolve` to a version using native `realpath`, which is faster than the default JS implementation ([#9872](https://github.com/facebook/jest/pull/9872))
 - `[jest-resolve]` Pass custom cached `realpath` function to `resolve` ([#9873](https://github.com/facebook/jest/pull/9873))
+- `[jest-runtime]` Add `teardown` method to clear any caches when tests complete ([#9906](https://github.com/facebook/jest/pull/9906))
 
 ## 25.4.0
 
diff --git a/packages/jest-runner/src/runTest.ts b/packages/jest-runner/src/runTest.ts
index dd8735be8b57..80c5ae5dc067 100644
--- a/packages/jest-runner/src/runTest.ts
+++ b/packages/jest-runner/src/runTest.ts
@@ -300,6 +300,8 @@ async function runTestInternal(
     });
   } finally {
     await environment.teardown();
+    // TODO: this function might be missing, remove ? in Jest 26
+    runtime.teardown?.();
 
     sourcemapSupport.resetRetrieveHandlers();
   }
diff --git a/packages/jest-runtime/src/index.ts b/packages/jest-runtime/src/index.ts
index ecb2d25f3ef8..59b48d66bc04 100644
--- a/packages/jest-runtime/src/index.ts
+++ b/packages/jest-runtime/src/index.ts
@@ -718,12 +718,17 @@ class Runtime {
     try {
       fn();
     } finally {
+      // might be cleared within the callback
+      this._isolatedModuleRegistry?.clear();
+      this._isolatedMockRegistry?.clear();
       this._isolatedModuleRegistry = null;
       this._isolatedMockRegistry = null;
     }
   }
 
   resetModules(): void {
+    this._isolatedModuleRegistry?.clear();
+    this._isolatedMockRegistry?.clear();
     this._isolatedModuleRegistry = null;
     this._isolatedMockRegistry = null;
     this._mockRegistry.clear();
@@ -833,6 +838,29 @@ class Runtime {
     this._moduleMocker.clearAllMocks();
   }
 
+  teardown(): void {
+    this.restoreAllMocks();
+    this.resetAllMocks();
+    this.resetModules();
+
+    this._internalModuleRegistry.clear();
+    this._mockFactories = {};
+    this._mockMetaDataCache = {};
+    this._shouldMockModuleCache = {};
+    this._shouldUnmockTransitiveDependenciesCache = {};
+    this._transitiveShouldMock = {};
+    this._virtualMocks = {};
+    this._cacheFS = {};
+
+    this._sourceMapRegistry = {};
+
+    this._fileTransforms.clear();
+    this.jestObjectCaches.clear();
+
+    this._v8CoverageResult = [];
+    this._moduleImplementation = undefined;
+  }
+
   private _resolveModule(from: Config.Path, to?: string) {
     return to ? this._resolver.resolveModule(from, to) : from;
   }