diff --git a/lib/dialects/sqlite3/schema/ddl.js b/lib/dialects/sqlite3/schema/ddl.js
index 5aaf569419..74f3b26981 100644
--- a/lib/dialects/sqlite3/schema/ddl.js
+++ b/lib/dialects/sqlite3/schema/ddl.js
@@ -344,6 +344,40 @@ class SQLite3_DDL {
     );
   }
 
+  setNullable(column, isNullable) {
+    return this.client.transaction(
+      async (trx) => {
+        this.trx = trx;
+
+        const { createTable, createIndices } = await this.getTableSql();
+
+        const parsedTable = parseCreateTable(createTable);
+        const parsedColumn = parsedTable.columns.find((c) =>
+          isEqualId(column, c.name)
+        );
+
+        if (!parsedColumn) {
+          throw new Error(
+            `.setNullable: Column ${column} does not exist in table ${this.tableName()}.`
+          );
+        }
+
+        parsedColumn.constraints.notnull = isNullable
+          ? null
+          : { name: null, conflict: null };
+
+        parsedColumn.constraints.null = isNullable
+          ? parsedColumn.constraints.null
+          : null;
+
+        const newTable = compileCreateTable(parsedTable, this.wrap);
+
+        return this.generateAlterCommands(newTable, createIndices);
+      },
+      { connection: this.connection }
+    );
+  }
+
   async alter(newSql, createIndices, columns) {
     await this.createNewTable(newSql);
     await this.copyData(columns);
diff --git a/lib/dialects/sqlite3/schema/sqlite-tablecompiler.js b/lib/dialects/sqlite3/schema/sqlite-tablecompiler.js
index 5aba13edbe..4627c70a9d 100644
--- a/lib/dialects/sqlite3/schema/sqlite-tablecompiler.js
+++ b/lib/dialects/sqlite3/schema/sqlite-tablecompiler.js
@@ -266,8 +266,16 @@ class TableCompiler_SQLite3 extends TableCompiler {
   }
 
   _setNullableState(column, isNullable) {
-    const fnCalled = isNullable ? '.setNullable' : '.dropNullable';
-    throw new Error(`${fnCalled} is not supported for SQLite.`);
+    const compiler = this;
+
+    this.pushQuery({
+      sql: `PRAGMA table_info(${this.tableName()})`,
+      statementsProducer(pragma, connection) {
+        return compiler.client
+          .ddl(compiler, pragma, connection)
+          .setNullable(column, isNullable);
+      },
+    });
   }
 
   dropColumn() {
diff --git a/test/integration2/schema/set-nullable.spec.js b/test/integration2/schema/set-nullable.spec.js
index 4061b279ce..03a46116ff 100644
--- a/test/integration2/schema/set-nullable.spec.js
+++ b/test/integration2/schema/set-nullable.spec.js
@@ -1,6 +1,7 @@
 const chai = require('chai');
 chai.use(require('chai-as-promised'));
 const expect = chai.expect;
+const sinon = require('sinon');
 const {
   isSQLite,
   isPostgreSQL,
@@ -16,13 +17,12 @@ describe('Schema', () => {
         let knex;
 
         before(function () {
+          sinon.stub(Math, 'random').returns(0.1);
           knex = getKnexForDb(db);
-          if (isSQLite(knex)) {
-            return this.skip();
-          }
         });
 
         after(() => {
+          sinon.restore();
           return knex.destroy();
         });
 
@@ -38,6 +38,31 @@ describe('Schema', () => {
         });
 
         describe('setNullable', () => {
+          it('should generate correct SQL for set nullable operation', async () => {
+            const builder = knex.schema.table('primary_table', (table) => {
+              table.setNullable('id_not_nullable');
+            });
+            const queries = await builder.generateDdlCommands();
+
+            if (isSQLite(knex)) {
+              expect(queries.sql).to.eql([
+                'CREATE TABLE `_knex_temp_alter111` (`id_nullable` integer NULL, `id_not_nullable` integer)',
+                'INSERT INTO _knex_temp_alter111 SELECT * FROM primary_table;',
+                'DROP TABLE "primary_table"',
+                'ALTER TABLE "_knex_temp_alter111" RENAME TO "primary_table"',
+              ]);
+            }
+
+            if (isPostgreSQL(knex)) {
+              expect(queries.sql).to.eql([
+                {
+                  bindings: [],
+                  sql: 'alter table "primary_table" alter column "id_not_nullable" drop not null',
+                },
+              ]);
+            }
+          });
+
           it('sets column to be nullable', async () => {
             await knex.schema.table('primary_table', (table) => {
               table.setNullable('id_not_nullable');
@@ -63,6 +88,9 @@ describe('Schema', () => {
               errorMessage = 'cannot be null';
             } else if (isOracle(knex)) {
               errorMessage = 'ORA-01400: cannot insert NULL into';
+            } else if (isSQLite(knex)) {
+              errorMessage =
+                'insert into `primary_table` (`id_not_nullable`, `id_nullable`) values (1, NULL) - SQLITE_CONSTRAINT: NOT NULL constraint failed: primary_table.id_nullable';
             }
 
             await expect(