diff --git a/docs/pages/material-ui/api/chip.json b/docs/pages/material-ui/api/chip.json
index c0aa34f7971e66..2d8251bf56d0f3 100644
--- a/docs/pages/material-ui/api/chip.json
+++ b/docs/pages/material-ui/api/chip.json
@@ -24,6 +24,7 @@
       },
       "default": "'medium'"
     },
+    "skipFocusWhenDisabled": { "type": { "name": "bool" } },
     "sx": {
       "type": {
         "name": "union",
diff --git a/docs/translations/api-docs/chip/chip.json b/docs/translations/api-docs/chip/chip.json
index 5012cbf664f9d0..2a39e6b8f90a2e 100644
--- a/docs/translations/api-docs/chip/chip.json
+++ b/docs/translations/api-docs/chip/chip.json
@@ -13,6 +13,7 @@
     "label": "The content of the component.",
     "onDelete": "Callback fired when the delete icon is clicked. If set, the delete icon will be shown.",
     "size": "The size of the component.",
+    "skipFocusWhenDisabled": "If <code>true</code>, allows the disabled chip to escape focus. If <code>false</code>, allows the disabled chip to receive focus.",
     "sx": "The system prop that allows defining system overrides as well as additional CSS styles. See the <a href=\"/system/getting-started/the-sx-prop/\">`sx` page</a> for more details.",
     "variant": "The variant to use."
   },
diff --git a/packages/mui-material/src/Chip/Chip.d.ts b/packages/mui-material/src/Chip/Chip.d.ts
index 9ff2c7a2767374..4e8644064f1a2c 100644
--- a/packages/mui-material/src/Chip/Chip.d.ts
+++ b/packages/mui-material/src/Chip/Chip.d.ts
@@ -72,10 +72,20 @@ export interface ChipTypeMap<P = {}, D extends React.ElementType = 'div'> {
      * @default 'medium'
      */
     size?: OverridableStringUnion<'small' | 'medium', ChipPropsSizeOverrides>;
+    /**
+     * If `true`, allows the disabled chip to escape focus.
+     * If `false`, allows the disabled chip to receive focus.
+     * @default false
+     */
+    skipFocusWhenDisabled?: boolean;
     /**
      * The system prop that allows defining system overrides as well as additional CSS styles.
      */
     sx?: SxProps<Theme>;
+    /**
+     *  @ignore
+     */
+    tabIndex?: number;
     /**
      * The variant to use.
      * @default 'filled'
diff --git a/packages/mui-material/src/Chip/Chip.js b/packages/mui-material/src/Chip/Chip.js
index 44bbe36d98464a..87925389a8fc51 100644
--- a/packages/mui-material/src/Chip/Chip.js
+++ b/packages/mui-material/src/Chip/Chip.js
@@ -346,6 +346,8 @@ const Chip = React.forwardRef(function Chip(inProps, ref) {
     onKeyUp,
     size = 'medium',
     variant = 'filled',
+    tabIndex,
+    skipFocusWhenDisabled = false, // TODO v6: Rename to `focusableWhenDisabled`.
     ...other
   } = props;
 
@@ -460,6 +462,7 @@ const Chip = React.forwardRef(function Chip(inProps, ref) {
       onKeyDown={handleKeyDown}
       onKeyUp={handleKeyUp}
       ref={handleRef}
+      tabIndex={skipFocusWhenDisabled && disabled ? -1 : tabIndex}
       ownerState={ownerState}
       {...moreProps}
       {...other}
@@ -561,6 +564,12 @@ Chip.propTypes /* remove-proptypes */ = {
     PropTypes.oneOf(['medium', 'small']),
     PropTypes.string,
   ]),
+  /**
+   * If `true`, allows the disabled chip to escape focus.
+   * If `false`, allows the disabled chip to receive focus.
+   * @default false
+   */
+  skipFocusWhenDisabled: PropTypes.bool,
   /**
    * The system prop that allows defining system overrides as well as additional CSS styles.
    */
@@ -569,6 +578,10 @@ Chip.propTypes /* remove-proptypes */ = {
     PropTypes.func,
     PropTypes.object,
   ]),
+  /**
+   * @ignore
+   */
+  tabIndex: PropTypes.number,
   /**
    * The variant to use.
    * @default 'filled'
diff --git a/packages/mui-material/src/Chip/Chip.test.js b/packages/mui-material/src/Chip/Chip.test.js
index 990328fe9525d5..904aeb9701ca18 100644
--- a/packages/mui-material/src/Chip/Chip.test.js
+++ b/packages/mui-material/src/Chip/Chip.test.js
@@ -174,6 +174,29 @@ describe('<Chip />', () => {
       expect(chip).to.have.class(classes.filledPrimary);
     });
 
+    it('should not be focused when a deletable chip is disabled and skipFocusWhenDisabled is true', () => {
+      const { getByTestId } = render(
+        <Chip
+          label="My Chip"
+          disabled
+          data-testid="chip"
+          skipFocusWhenDisabled
+          onDelete={() => {}}
+        />,
+      );
+
+      const chip = getByTestId('chip');
+
+      simulatePointerDevice();
+      act(() => {
+        fireEvent.keyDown(document.body, { key: 'Tab' });
+      });
+
+      expect(chip).to.have.class(classes.root);
+      expect(chip).to.have.property('tabIndex', -1);
+      expect(chip).not.to.have.class(classes.focusVisible);
+    });
+
     it('should render with the root and filled clickable secondary class', () => {
       const { getByRole } = render(
         <Chip color="secondary" label="My Chip" onClick={() => {}} variant="filled" />,