diff --git a/js.go b/js.go
index 23480abc7..7001220e1 100644
--- a/js.go
+++ b/js.go
@@ -336,10 +336,10 @@ type pubOpts struct {
 	ctx context.Context
 	ttl time.Duration
 	id  string
-	lid string // Expected last msgId
-	str string // Expected stream name
-	seq uint64 // Expected last sequence
-	lss uint64 // Expected last sequence per subject
+	lid string  // Expected last msgId
+	str string  // Expected stream name
+	seq *uint64 // Expected last sequence
+	lss *uint64 // Expected last sequence per subject
 
 	// Publish retries for NoResponders err.
 	rwait time.Duration // Retry wait between attempts
@@ -415,11 +415,11 @@ func (js *js) PublishMsg(m *Msg, opts ...PubOpt) (*PubAck, error) {
 	if o.str != _EMPTY_ {
 		m.Header.Set(ExpectedStreamHdr, o.str)
 	}
-	if o.seq > 0 {
-		m.Header.Set(ExpectedLastSeqHdr, strconv.FormatUint(o.seq, 10))
+	if o.seq != nil {
+		m.Header.Set(ExpectedLastSeqHdr, strconv.FormatUint(*o.seq, 10))
 	}
-	if o.lss > 0 {
-		m.Header.Set(ExpectedLastSubjSeqHdr, strconv.FormatUint(o.lss, 10))
+	if o.lss != nil {
+		m.Header.Set(ExpectedLastSubjSeqHdr, strconv.FormatUint(*o.lss, 10))
 	}
 
 	var resp *Msg
@@ -749,11 +749,11 @@ func (js *js) PublishMsgAsync(m *Msg, opts ...PubOpt) (PubAckFuture, error) {
 	if o.str != _EMPTY_ {
 		m.Header.Set(ExpectedStreamHdr, o.str)
 	}
-	if o.seq > 0 {
-		m.Header.Set(ExpectedLastSeqHdr, strconv.FormatUint(o.seq, 10))
+	if o.seq != nil {
+		m.Header.Set(ExpectedLastSeqHdr, strconv.FormatUint(*o.seq, 10))
 	}
-	if o.lss > 0 {
-		m.Header.Set(ExpectedLastSubjSeqHdr, strconv.FormatUint(o.lss, 10))
+	if o.lss != nil {
+		m.Header.Set(ExpectedLastSubjSeqHdr, strconv.FormatUint(*o.lss, 10))
 	}
 
 	// Reply
@@ -822,7 +822,7 @@ func ExpectStream(stream string) PubOpt {
 // ExpectLastSequence sets the expected sequence in the response from the publish.
 func ExpectLastSequence(seq uint64) PubOpt {
 	return pubOptFn(func(opts *pubOpts) error {
-		opts.seq = seq
+		opts.seq = &seq
 		return nil
 	})
 }
@@ -830,7 +830,7 @@ func ExpectLastSequence(seq uint64) PubOpt {
 // ExpectLastSequencePerSubject sets the expected sequence per subject in the response from the publish.
 func ExpectLastSequencePerSubject(seq uint64) PubOpt {
 	return pubOptFn(func(opts *pubOpts) error {
-		opts.lss = seq
+		opts.lss = &seq
 		return nil
 	})
 }
diff --git a/test/js_test.go b/test/js_test.go
index 43554efbb..b56a2529b 100644
--- a/test/js_test.go
+++ b/test/js_test.go
@@ -5481,6 +5481,85 @@ func TestJetStreamPublishAsyncPerf(t *testing.T) {
 	fmt.Printf("%.0f msgs/sec\n\n", float64(toSend)/tt.Seconds())
 }
 
+func TestJetStreamPublishExpectZero(t *testing.T) {
+	s := RunBasicJetStreamServer()
+	defer shutdownJSServerAndRemoveStorage(t, s)
+
+	nc, js := jsClient(t, s)
+	defer nc.Close()
+
+	var err error
+
+	// Create the stream using our client API.
+	_, err = js.AddStream(&nats.StreamConfig{
+		Name:     "TEST",
+		Subjects: []string{"test", "foo", "bar"},
+	})
+	if err != nil {
+		t.Fatalf("Unexpected error: %v", err)
+	}
+
+	sub, err := nc.SubscribeSync("foo")
+	if err != nil {
+		t.Errorf("Error: %s", err)
+	}
+
+	// Explicitly set the header to zero.
+	_, err = js.Publish("foo", []byte("bar"),
+		nats.ExpectLastSequence(0),
+		nats.ExpectLastSequencePerSubject(0),
+	)
+	if err != nil {
+		t.Errorf("Error: %v", err)
+	}
+
+	rawMsg, err := js.GetMsg("TEST", 1)
+	if err != nil {
+		t.Fatalf("Error: %s", err)
+	}
+	hdr, ok := rawMsg.Header["Nats-Expected-Last-Sequence"]
+	if !ok {
+		t.Fatal("Missing header")
+	}
+	got := hdr[0]
+	expected := "0"
+	if got != expected {
+		t.Fatalf("Expected %v, got: %v", expected, got)
+	}
+	hdr, ok = rawMsg.Header["Nats-Expected-Last-Subject-Sequence"]
+	if !ok {
+		t.Fatal("Missing header")
+	}
+	got = hdr[0]
+	expected = "0"
+	if got != expected {
+		t.Fatalf("Expected %v, got: %v", expected, got)
+	}
+
+	msg, err := sub.NextMsg(1 * time.Second)
+	if err != nil {
+		t.Fatalf("Error: %s", err)
+	}
+	hdr, ok = msg.Header["Nats-Expected-Last-Sequence"]
+	if !ok {
+		t.Fatal("Missing header")
+	}
+	got = hdr[0]
+	expected = "0"
+	if got != expected {
+		t.Fatalf("Expected %v, got: %v", expected, got)
+	}
+	hdr, ok = msg.Header["Nats-Expected-Last-Subject-Sequence"]
+	if !ok {
+		t.Fatal("Missing header")
+	}
+	got = hdr[0]
+	expected = "0"
+	if got != expected {
+		t.Fatalf("Expected %v, got: %v", expected, got)
+	}
+}
+
 func TestJetStreamBindConsumer(t *testing.T) {
 	s := RunBasicJetStreamServer()
 	defer shutdownJSServerAndRemoveStorage(t, s)