diff --git a/lib/internal/child_process/serialization.js b/lib/internal/child_process/serialization.js
index df8a6ca67236c5..30713d0315d450 100644
--- a/lib/internal/child_process/serialization.js
+++ b/lib/internal/child_process/serialization.js
@@ -10,6 +10,7 @@ const { StringDecoder } = require('string_decoder');
 const v8 = require('v8');
 const { isArrayBufferView } = require('internal/util/types');
 const assert = require('internal/assert');
+const { streamBaseState, kLastWriteWasAsync } = internalBinding('stream_wrap');
 
 const kMessageBuffer = Symbol('kMessageBuffer');
 const kJSONBuffer = Symbol('kJSONBuffer');
@@ -80,10 +81,16 @@ const advanced = {
     const serializedMessage = ser.releaseBuffer();
     const sizeBuffer = Buffer.allocUnsafe(4);
     sizeBuffer.writeUInt32BE(serializedMessage.length);
-    return channel.writeBuffer(req, Buffer.concat([
+
+    const buffer = Buffer.concat([
       sizeBuffer,
-      serializedMessage
-    ]), handle);
+      serializedMessage,
+    ]);
+    const result = channel.writeBuffer(req, buffer, handle);
+    // Mirror what stream_base_commons.js does for Buffer retention.
+    if (streamBaseState[kLastWriteWasAsync])
+      req.buffer = buffer;
+    return result;
   },
 };
 
diff --git a/test/parallel/test-child-process-advanced-serialization-largebuffer.js b/test/parallel/test-child-process-advanced-serialization-largebuffer.js
new file mode 100644
index 00000000000000..4e80bce40570f9
--- /dev/null
+++ b/test/parallel/test-child-process-advanced-serialization-largebuffer.js
@@ -0,0 +1,27 @@
+'use strict';
+const common = require('../common');
+const assert = require('assert');
+const child_process = require('child_process');
+
+// Regression test for https://github.com/nodejs/node/issues/34797
+const eightMB = 8 * 1024 * 1024;
+
+if (process.argv[2] === 'child') {
+  for (let i = 0; i < 4; i++) {
+    process.send(new Uint8Array(eightMB).fill(i));
+  }
+} else {
+  const child = child_process.spawn(process.execPath, [__filename, 'child'], {
+    stdio: ['inherit', 'inherit', 'inherit', 'ipc'],
+    serialization: 'advanced'
+  });
+  const received = [];
+  child.on('message', common.mustCall((chunk) => {
+    assert.deepStrictEqual(chunk, new Uint8Array(eightMB).fill(chunk[0]));
+
+    received.push(chunk[0]);
+    if (received.length === 4) {
+      assert.deepStrictEqual(received, [0, 1, 2, 3]);
+    }
+  }, 4));
+}