diff --git a/test/sequential/sequential.status b/test/sequential/sequential.status
index 9fc935f00d96ab..3d432b7bbb0dd3 100644
--- a/test/sequential/sequential.status
+++ b/test/sequential/sequential.status
@@ -15,6 +15,8 @@ test-worker-prof: PASS, FLAKY
 [$system==linux]
 
 [$system==macos]
+# https://github.com/nodejs/node/issues/21781
+test-timers-blocking-callback: PASS, FLAKY
 
 [$system==solaris] # Also applies to SmartOS