diff --git a/.eslintrc.js b/.eslintrc.js
index da17fd47acd4b9..c7c7cc56051b1c 100644
--- a/.eslintrc.js
+++ b/.eslintrc.js
@@ -340,5 +340,9 @@ module.exports = {
     Headers: 'readable',
     Request: 'readable',
     Response: 'readable',
+    crypto: 'readable',
+    Crypto: 'readable',
+    CryptoKey: 'readable',
+    SubtleCrypto: 'readable',
   },
 };
diff --git a/doc/api/cli.md b/doc/api/cli.md
index 10500f130a6b28..a551a3fff9cec6 100644
--- a/doc/api/cli.md
+++ b/doc/api/cli.md
@@ -288,6 +288,14 @@ added: v17.5.0
 
 Enable experimental support for the [Fetch API][].
 
+### `--experimental-global-webcrypto`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+Expose the [Web Crypto API][] on the global scope.
+
 ### `--experimental-import-meta-resolve`
 
 <!-- YAML
@@ -1580,6 +1588,7 @@ Node.js options that are allowed are:
 * `--enable-source-maps`
 * `--experimental-abortcontroller`
 * `--experimental-fetch`
+* `--experimental-global-webcrypto`
 * `--experimental-import-meta-resolve`
 * `--experimental-json-modules`
 * `--experimental-loader`
@@ -1982,6 +1991,7 @@ $ node --max-old-space-size=1536 index.js
 [Source Map]: https://sourcemaps.info/spec.html
 [Subresource Integrity]: https://developer.mozilla.org/en-US/docs/Web/Security/Subresource_Integrity
 [V8 JavaScript code coverage]: https://v8project.blogspot.com/2017/12/javascript-code-coverage.html
+[Web Crypto API]: webcrypto.md
 [`"type"`]: packages.md#type
 [`--cpu-prof-dir`]: #--cpu-prof-dir
 [`--diagnostic-dir`]: #--diagnostic-dirdirectory
diff --git a/doc/api/crypto.md b/doc/api/crypto.md
index 0e56f12a6fdf3a..e5b83eb4ff5dd0 100644
--- a/doc/api/crypto.md
+++ b/doc/api/crypto.md
@@ -41,6 +41,8 @@ calling `require('crypto')` will result in an error being thrown.
 
 When using CommonJS, the error thrown can be caught using try/catch:
 
+<!-- eslint-skip -->
+
 ```cjs
 let crypto;
 try {
diff --git a/doc/api/globals.md b/doc/api/globals.md
index 1fa6801dda66c9..f4ea4fb474724f 100644
--- a/doc/api/globals.md
+++ b/doc/api/globals.md
@@ -307,6 +307,43 @@ added: v0.1.100
 
 Used to print to stdout and stderr. See the [`console`][] section.
 
+## `Crypto`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+> Stability: 1 - Experimental. Enable this API with the
+> [`--experimental-global-webcrypto`][] CLI flag.
+
+A browser-compatible implementation of {Crypto}. This global is available
+only if the Node.js binary was compiled with including support for the
+`crypto` module.
+
+## `crypto`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+> Stability: 1 - Experimental. Enable this API with the
+> [`--experimental-global-webcrypto`][] CLI flag.
+
+A browser-compatible implementation of the [Web Crypto API][].
+
+## `CryptoKey`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+> Stability: 1 - Experimental. Enable this API with the
+> [`--experimental-global-webcrypto`][] CLI flag.
+
+A browser-compatible implementation of {CryptoKey}. This global is available
+only if the Node.js binary was compiled with including support for the
+`crypto` module.
+
 ## `Event`
 
 <!-- YAML
@@ -534,6 +571,19 @@ added: v17.0.0
 
 The WHATWG [`structuredClone`][] method.
 
+## `SubtleCrypto`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+> Stability: 1 - Experimental. Enable this API with the
+> [`--experimental-global-webcrypto`][] CLI flag.
+
+A browser-compatible implementation of {SubtleCrypto}. This global is available
+only if the Node.js binary was compiled with including support for the
+`crypto` module.
+
 ## `DOMException`
 
 <!-- YAML
@@ -598,7 +648,9 @@ The object that acts as the namespace for all W3C
 [WebAssembly][webassembly-org] related functionality. See the
 [Mozilla Developer Network][webassembly-mdn] for usage and compatibility.
 
+[Web Crypto API]: webcrypto.md
 [`--experimental-fetch`]: cli.md#--experimental-fetch
+[`--experimental-global-webcrypto`]: cli.md#--experimental-global-webcrypto
 [`AbortController`]: https://developer.mozilla.org/en-US/docs/Web/API/AbortController
 [`DOMException`]: https://developer.mozilla.org/en-US/docs/Web/API/DOMException
 [`EventTarget` and `Event` API]: events.md#eventtarget-and-event-api
diff --git a/doc/node.1 b/doc/node.1
index 86a5bd865ae51b..972487be1218ee 100644
--- a/doc/node.1
+++ b/doc/node.1
@@ -142,6 +142,9 @@ Enable Source Map V3 support for stack traces.
 .It Fl -experimental-fetch
 Enable experimental support for the Fetch API.
 .
+.It Fl -experimental-global-webcrypto
+Expose the Web Crypto API on the global scope.
+.
 .It Fl -experimental-import-meta-resolve
 Enable experimental ES modules support for import.meta.resolve().
 .
diff --git a/lib/.eslintrc.yaml b/lib/.eslintrc.yaml
index c5e1058a3068e1..709c5f4c93e1e3 100644
--- a/lib/.eslintrc.yaml
+++ b/lib/.eslintrc.yaml
@@ -79,6 +79,12 @@ rules:
       message: "Use `const { atob } = require('buffer');` instead of the global."
     - name: btoa
       message: "Use `const { btoa } = require('buffer');` instead of the global."
+    - name: crypto
+      message: "Use `const { crypto } = require('internal/crypto/webcrypto');` instead of the global."
+    - name: Crypto
+      message: "Use `const { Crypto } = require('internal/crypto/webcrypto');` instead of the global."
+    - name: CryptoKey
+      message: "Use `const { CryptoKey } = require('internal/crypto/webcrypto');` instead of the global."
     - name: global
       message: "Use `const { globalThis } = primordials;` instead of `global`."
     - name: globalThis
@@ -89,6 +95,8 @@ rules:
       message: "Use `const { queueMicrotask } = require('internal/process/task_queues');` instead of the global."
     - name: structuredClone
       message: "Use `const { structuredClone } = require('internal/structured_clone');` instead of the global."
+    - name: SubtleCrypto
+      message: "Use `const { SubtleCrypto } = require('internal/crypto/webcrypto');` instead of the global."
   # Custom rules in tools/eslint-rules
   node-core/lowercase-name-for-primitive: error
   node-core/non-ascii-character: error
diff --git a/lib/internal/bootstrap/pre_execution.js b/lib/internal/bootstrap/pre_execution.js
index 1fe56478e0ab3f..ca7063ac90d87d 100644
--- a/lib/internal/bootstrap/pre_execution.js
+++ b/lib/internal/bootstrap/pre_execution.js
@@ -3,6 +3,7 @@
 const {
   NumberParseInt,
   ObjectDefineProperty,
+  ObjectGetOwnPropertyDescriptor,
   SafeMap,
   SafeWeakMap,
   StringPrototypeStartsWith,
@@ -36,6 +37,7 @@ function prepareMainThreadExecution(expandArgv1 = false) {
   setupInspectorHooks();
   setupWarningHandler();
   setupFetch();
+  setupWebCrypto();
 
   // Resolve the coverage directory to an absolute path, and
   // overwrite process.env so that the original path gets passed
@@ -162,6 +164,29 @@ function setupFetch() {
   exposeInterface(globalThis, 'Response', undici.Response);
 }
 
+// TODO(aduh95): move this to internal/bootstrap/browser when the CLI flag is
+//               removed.
+function setupWebCrypto() {
+  if (!getOptionValue('--experimental-global-webcrypto')) {
+    return;
+  }
+
+  let webcrypto;
+  ObjectDefineProperty(globalThis, 'crypto',
+                       ObjectGetOwnPropertyDescriptor({
+                         get crypto() {
+                           webcrypto ??= require('internal/crypto/webcrypto');
+                           return webcrypto.crypto;
+                         }
+                       }, 'crypto'));
+  if (internalBinding('config').hasOpenSSL) {
+    webcrypto ??= require('internal/crypto/webcrypto');
+    exposeInterface(globalThis, 'Crypto', webcrypto.Crypto);
+    exposeInterface(globalThis, 'CryptoKey', webcrypto.CryptoKey);
+    exposeInterface(globalThis, 'SubtleCrypto', webcrypto.SubtleCrypto);
+  }
+}
+
 // Setup User-facing NODE_V8_COVERAGE environment variable that writes
 // ScriptCoverage to a specified file.
 function setupCoverageHooks(dir) {
@@ -503,6 +528,7 @@ module.exports = {
   setupCoverageHooks,
   setupWarningHandler,
   setupFetch,
+  setupWebCrypto,
   setupDebugEnv,
   setupPerfHooks,
   prepareMainThreadExecution,
diff --git a/lib/internal/crypto/webcrypto.js b/lib/internal/crypto/webcrypto.js
index c022bb44223b5b..8e3822494be230 100644
--- a/lib/internal/crypto/webcrypto.js
+++ b/lib/internal/crypto/webcrypto.js
@@ -808,6 +808,7 @@ ObjectDefineProperties(
 
 module.exports = {
   Crypto,
+  CryptoKey,
   SubtleCrypto,
   crypto,
 };
diff --git a/lib/internal/main/worker_thread.js b/lib/internal/main/worker_thread.js
index 5e24b84e14c934..a5816f1f1cf4ee 100644
--- a/lib/internal/main/worker_thread.js
+++ b/lib/internal/main/worker_thread.js
@@ -18,6 +18,7 @@ const {
   setupInspectorHooks,
   setupWarningHandler,
   setupFetch,
+  setupWebCrypto,
   setupDebugEnv,
   setupPerfHooks,
   initializeDeprecations,
@@ -69,6 +70,7 @@ setupDebugEnv();
 
 setupWarningHandler();
 setupFetch();
+setupWebCrypto();
 initializeSourceMapsHandlers();
 
 // Since worker threads cannot switch cwd, we do not need to
diff --git a/src/node_options.cc b/src/node_options.cc
index bac3de2404b5c3..ab3b736e07d8e9 100644
--- a/src/node_options.cc
+++ b/src/node_options.cc
@@ -319,6 +319,10 @@ EnvironmentOptionsParser::EnvironmentOptionsParser() {
             "experimental Fetch API",
             &EnvironmentOptions::experimental_fetch,
             kAllowedInEnvironment);
+  AddOption("--experimental-global-webcrypto",
+            "expose experimental Web Crypto API on the global scope",
+            &EnvironmentOptions::experimental_global_web_crypto,
+            kAllowedInEnvironment);
   AddOption("--experimental-json-modules", "", NoOp{}, kAllowedInEnvironment);
   AddOption("--experimental-loader",
             "use the specified module as a custom loader",
diff --git a/src/node_options.h b/src/node_options.h
index 6042f5e7f5e804..0ded5d89beef7c 100644
--- a/src/node_options.h
+++ b/src/node_options.h
@@ -108,6 +108,7 @@ class EnvironmentOptions : public Options {
   std::string dns_result_order;
   bool enable_source_maps = false;
   bool experimental_fetch = false;
+  bool experimental_global_web_crypto = false;
   bool experimental_https_modules = false;
   std::string experimental_specifier_resolution;
   bool experimental_wasm_modules = false;
diff --git a/test/common/index.js b/test/common/index.js
index fdffecb9af1048..46a59b54d52459 100644
--- a/test/common/index.js
+++ b/test/common/index.js
@@ -308,6 +308,12 @@ if (global.fetch) {
     global.Headers,
   );
 }
+if (hasCrypto && global.crypto) {
+  knownGlobals.push(global.crypto);
+  knownGlobals.push(global.Crypto);
+  knownGlobals.push(global.CryptoKey);
+  knownGlobals.push(global.SubtleCrypto);
+}
 
 function allowGlobals(...allowlist) {
   knownGlobals = knownGlobals.concat(allowlist);
diff --git a/test/parallel/test-global-webcrypto-classes.js b/test/parallel/test-global-webcrypto-classes.js
new file mode 100644
index 00000000000000..083592bd92278c
--- /dev/null
+++ b/test/parallel/test-global-webcrypto-classes.js
@@ -0,0 +1,13 @@
+// Flags: --experimental-global-webcrypto --expose-internals
+'use strict';
+
+const common = require('../common');
+if (!common.hasCrypto)
+  common.skip('missing crypto');
+
+const assert = require('assert');
+const webcrypto = require('internal/crypto/webcrypto');
+
+assert.strictEqual(Crypto, webcrypto.Crypto);
+assert.strictEqual(CryptoKey, webcrypto.CryptoKey);
+assert.strictEqual(SubtleCrypto, webcrypto.SubtleCrypto);
diff --git a/test/parallel/test-global-webcrypto.js b/test/parallel/test-global-webcrypto.js
new file mode 100644
index 00000000000000..70f84a1b3a0643
--- /dev/null
+++ b/test/parallel/test-global-webcrypto.js
@@ -0,0 +1,13 @@
+// Flags: --experimental-global-webcrypto
+'use strict';
+
+const common = require('../common');
+if (!common.hasCrypto)
+  common.skip('missing crypto');
+
+const assert = require('assert');
+const crypto = require('crypto');
+
+assert.strictEqual(globalThis.crypto, crypto.webcrypto);
+assert.strictEqual(Crypto, crypto.webcrypto.constructor);
+assert.strictEqual(SubtleCrypto, crypto.webcrypto.subtle.constructor);