diff --git a/doc/api/stream.md b/doc/api/stream.md
index 92dfe1a42a39bb..1a2d14f865f5e5 100644
--- a/doc/api/stream.md
+++ b/doc/api/stream.md
@@ -1555,17 +1555,30 @@ const cleanup = finished(rs, (err) => {
 });
 ```
 
-### `stream.pipeline(...streams, callback)`
+### `stream.pipeline(source, ...transforms, destination, callback)`
 <!-- YAML
 added: v10.0.0
--->
-
-* `...streams` {Stream} Two or more streams to pipe between.
+changes:
+  - version: REPLACEME
+    pr-url: https://github.com/nodejs/node/pull/31223
+    description: Add support for async generators.
+-->
+
+* `source` {Stream|Iterable|AsyncIterable|Function}
+  * Returns: {Iterable|AsyncIterable}
+* `...transforms` {Stream|Function}
+  * `source` {AsyncIterable}
+  * Returns: {AsyncIterable}
+* `destination` {Stream|Function}
+  * `source` {AsyncIterable}
+  * Returns: {AsyncIterable|Promise}
 * `callback` {Function} Called when the pipeline is fully done.
   * `err` {Error}
+  * `val` Resolved value of `Promise` returned by `destination`.
+* Returns: {Stream}
 
-A module method to pipe between streams forwarding errors and properly cleaning
-up and provide a callback when the pipeline is complete.
+A module method to pipe between streams and generators forwarding errors and
+properly cleaning up and provide a callback when the pipeline is complete.
 
 ```js
 const { pipeline } = require('stream');
@@ -1608,6 +1621,28 @@ async function run() {
 run().catch(console.error);
 ```
 
+The `pipeline` API also supports async generators:
+
+```js
+const pipeline = util.promisify(stream.pipeline);
+const fs = require('fs').promises;
+
+async function run() {
+  await pipeline(
+    fs.createReadStream('lowercase.txt'),
+    async function* (source) {
+      for await (const chunk of source) {
+        yield String(chunk).toUpperCase();
+      }
+    },
+    fs.createWriteStream('uppercase.txt')
+  );
+  console.log('Pipeline succeeded.');
+}
+
+run().catch(console.error);
+```
+
 `stream.pipeline()` will call `stream.destroy(err)` on all streams except:
 * `Readable` streams which have emitted `'end'` or `'close'`.
 * `Writable` streams which have emitted `'finish'` or `'close'`.
@@ -2707,8 +2742,7 @@ const pipeline = util.promisify(stream.pipeline);
 const writable = fs.createWriteStream('./file');
 
 (async function() {
-  const readable = Readable.from(iterable);
-  await pipeline(readable, writable);
+  await pipeline(iterable, writable);
 })();
 ```
 
@@ -2843,7 +2877,7 @@ contain multi-byte characters.
 [`stream.cork()`]: #stream_writable_cork
 [`stream.finished()`]: #stream_stream_finished_stream_options_callback
 [`stream.pipe()`]: #stream_readable_pipe_destination_options
-[`stream.pipeline()`]: #stream_stream_pipeline_streams_callback
+[`stream.pipeline()`]: #stream_stream_pipeline_source_transforms_destination_callback
 [`stream.uncork()`]: #stream_writable_uncork
 [`stream.unpipe()`]: #stream_readable_unpipe_destination
 [`stream.wrap()`]: #stream_readable_wrap_stream
diff --git a/lib/internal/streams/pipeline.js b/lib/internal/streams/pipeline.js
index 92a91c30171af1..e0834171bfb8fc 100644
--- a/lib/internal/streams/pipeline.js
+++ b/lib/internal/streams/pipeline.js
@@ -5,21 +5,37 @@
 
 const {
   ArrayIsArray,
+  SymbolAsyncIterator,
+  SymbolIterator
 } = primordials;
 
 let eos;
 
 const { once } = require('internal/util');
 const {
+  ERR_INVALID_ARG_TYPE,
+  ERR_INVALID_RETURN_VALUE,
   ERR_INVALID_CALLBACK,
   ERR_MISSING_ARGS,
   ERR_STREAM_DESTROYED
 } = require('internal/errors').codes;
 
+let EE;
+let PassThrough;
+let createReadableStreamAsyncIterator;
+
 function isRequest(stream) {
   return stream && stream.setHeader && typeof stream.abort === 'function';
 }
 
+function destroyStream(stream, err) {
+  // request.destroy just do .end - .abort is what we want
+  if (isRequest(stream)) return stream.abort();
+  if (isRequest(stream.req)) return stream.req.abort();
+  if (typeof stream.destroy === 'function') return stream.destroy(err);
+  if (typeof stream.close === 'function') return stream.close();
+}
+
 function destroyer(stream, reading, writing, callback) {
   callback = once(callback);
 
@@ -41,19 +57,12 @@ function destroyer(stream, reading, writing, callback) {
     if (destroyed) return;
     destroyed = true;
 
-    // request.destroy just do .end - .abort is what we want
-    if (isRequest(stream)) return stream.abort();
-    if (isRequest(stream.req)) return stream.req.abort();
-    if (typeof stream.destroy === 'function') return stream.destroy(err);
+    destroyStream(stream, err);
 
     callback(err || new ERR_STREAM_DESTROYED('pipe'));
   };
 }
 
-function pipe(from, to) {
-  return from.pipe(to);
-}
-
 function popCallback(streams) {
   // Streams should never be an empty array. It should always contain at least
   // a single stream. Therefore optimize for the average case instead of
@@ -63,8 +72,89 @@ function popCallback(streams) {
   return streams.pop();
 }
 
+function isPromise(obj) {
+  return !!(obj && typeof obj.then === 'function');
+}
+
+function isReadable(obj) {
+  return !!(obj && typeof obj.pipe === 'function');
+}
+
+function isWritable(obj) {
+  return !!(obj && typeof obj.write === 'function');
+}
+
+function isStream(obj) {
+  return isReadable(obj) || isWritable(obj);
+}
+
+function isIterable(obj, isAsync) {
+  if (!obj) return false;
+  if (isAsync === true) return typeof obj[SymbolAsyncIterator] === 'function';
+  if (isAsync === false) return typeof obj[SymbolIterator] === 'function';
+  return typeof obj[SymbolAsyncIterator] === 'function' ||
+    typeof obj[SymbolIterator] === 'function';
+}
+
+function makeAsyncIterable(val) {
+  if (isIterable(val)) {
+    return val;
+  } else if (isReadable(val)) {
+    // Legacy streams are not Iterable.
+    return _fromReadable(val);
+  } else {
+    throw new ERR_INVALID_ARG_TYPE(
+      'val', ['Readable', 'Iterable', 'AsyncIterable'], val);
+  }
+}
+
+async function* _fromReadable(val) {
+  if (!createReadableStreamAsyncIterator) {
+    createReadableStreamAsyncIterator =
+      require('internal/streams/async_iterator');
+  }
+
+  try {
+    if (typeof val.read !== 'function') {
+      // createReadableStreamAsyncIterator does not support
+      // v1 streams. Convert it into a v2 stream.
+
+      if (!PassThrough) {
+        PassThrough = require('_stream_passthrough');
+      }
+
+      const pt = new PassThrough();
+      val
+        .on('error', (err) => pt.destroy(err))
+        .pipe(pt);
+      yield* createReadableStreamAsyncIterator(pt);
+    } else {
+      yield* createReadableStreamAsyncIterator(val);
+    }
+  } finally {
+    destroyStream(val);
+  }
+}
+
+async function pump(iterable, writable, finish) {
+  if (!EE) {
+    EE = require('events');
+  }
+  try {
+    for await (const chunk of iterable) {
+      if (!writable.write(chunk)) {
+        if (writable.destroyed) return;
+        await EE.once(writable, 'drain');
+      }
+    }
+    writable.end();
+  } catch (err) {
+    finish(err);
+  }
+}
+
 function pipeline(...streams) {
-  const callback = popCallback(streams);
+  const callback = once(popCallback(streams));
 
   if (ArrayIsArray(streams[0])) streams = streams[0];
 
@@ -73,25 +163,104 @@ function pipeline(...streams) {
   }
 
   let error;
-  const destroys = streams.map(function(stream, i) {
+  const destroys = [];
+
+  function finish(err, val, final) {
+    if (!error && err) {
+      error = err;
+    }
+
+    if (error || final) {
+      for (const destroy of destroys) {
+        destroy(error);
+      }
+    }
+
+    if (final) {
+      callback(error, val);
+    }
+  }
+
+  function wrap(stream, reading, writing, final) {
+    destroys.push(destroyer(stream, reading, writing, (err) => {
+      finish(err, null, final);
+    }));
+  }
+
+  let ret;
+  for (let i = 0; i < streams.length; i++) {
+    const stream = streams[i];
     const reading = i < streams.length - 1;
     const writing = i > 0;
-    return destroyer(stream, reading, writing, function(err) {
-      if (!error) error = err;
-      if (err) {
-        for (const destroy of destroys) {
-          destroy(err);
+
+    if (isStream(stream)) {
+      wrap(stream, reading, writing, !reading);
+    }
+
+    if (i === 0) {
+      if (typeof stream === 'function') {
+        ret = stream();
+        if (!isIterable(ret)) {
+          throw new ERR_INVALID_RETURN_VALUE(
+            'Iterable, AsyncIterable or Stream', 'source', ret);
         }
+      } else if (isIterable(stream) || isReadable(stream)) {
+        ret = stream;
+      } else {
+        throw new ERR_INVALID_ARG_TYPE(
+          'source', ['Stream', 'Iterable', 'AsyncIterable', 'Function'],
+          stream);
       }
-      if (reading) return;
-      for (const destroy of destroys) {
-        destroy();
+    } else if (typeof stream === 'function') {
+      ret = makeAsyncIterable(ret);
+      ret = stream(ret);
+
+      if (reading) {
+        if (!isIterable(ret, true)) {
+          throw new ERR_INVALID_RETURN_VALUE(
+            'AsyncIterable', `transform[${i - 1}]`, ret);
+        }
+      } else {
+        if (!PassThrough) {
+          PassThrough = require('_stream_passthrough');
+        }
+
+        const pt = new PassThrough();
+        if (isPromise(ret)) {
+          ret
+            .then((val) => {
+              pt.end(val);
+              finish(null, val, true);
+            })
+            .catch((err) => {
+              finish(err, null, true);
+            });
+        } else if (isIterable(ret, true)) {
+          pump(ret, pt, finish);
+        } else {
+          throw new ERR_INVALID_RETURN_VALUE(
+            'AsyncIterable or Promise', 'destination', ret);
+        }
+
+        ret = pt;
+        wrap(ret, true, false, true);
       }
-      callback(error);
-    });
-  });
+    } else if (isStream(stream)) {
+      if (isReadable(ret)) {
+        ret.pipe(stream);
+      } else {
+        ret = makeAsyncIterable(ret);
+        pump(ret, stream, finish);
+      }
+      ret = stream;
+    } else {
+      const name = reading ? `transform[${i - 1}]` : 'destination';
+      throw new ERR_INVALID_ARG_TYPE(
+        name, ['Stream', 'Function'], ret);
+    }
+  }
 
-  return streams.reduce(pipe);
+  return ret;
 }
 
 module.exports = pipeline;
diff --git a/test/parallel/test-stream-pipeline.js b/test/parallel/test-stream-pipeline.js
index f6ee97ba43d053..19fc246e2bf3cd 100644
--- a/test/parallel/test-stream-pipeline.js
+++ b/test/parallel/test-stream-pipeline.js
@@ -516,3 +516,400 @@ const { promisify } = require('util');
     }).on('error', common.mustNotCall());
   });
 }
+
+{
+  let res = '';
+  const w = new Writable({
+    write(chunk, encoding, callback) {
+      res += chunk;
+      callback();
+    }
+  });
+  pipeline(function*() {
+    yield 'hello';
+    yield 'world';
+  }(), w, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'helloworld');
+  }));
+}
+
+{
+  let res = '';
+  const w = new Writable({
+    write(chunk, encoding, callback) {
+      res += chunk;
+      callback();
+    }
+  });
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }(), w, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'helloworld');
+  }));
+}
+
+{
+  let res = '';
+  const w = new Writable({
+    write(chunk, encoding, callback) {
+      res += chunk;
+      callback();
+    }
+  });
+  pipeline(function*() {
+    yield 'hello';
+    yield 'world';
+  }, w, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'helloworld');
+  }));
+}
+
+{
+  let res = '';
+  const w = new Writable({
+    write(chunk, encoding, callback) {
+      res += chunk;
+      callback();
+    }
+  });
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, w, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'helloworld');
+  }));
+}
+
+{
+  let res = '';
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, async function*(source) {
+    for await (const chunk of source) {
+      yield chunk.toUpperCase();
+    }
+  }, async function(source) {
+    for await (const chunk of source) {
+      res += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'HELLOWORLD');
+  }));
+}
+
+{
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, async function*(source) {
+    const ret = [];
+    for await (const chunk of source) {
+      ret.push(chunk.toUpperCase());
+    }
+    yield ret;
+  }, async function(source) {
+    let ret = '';
+    for await (const chunk of source) {
+      ret += chunk;
+    }
+    return ret;
+  }, common.mustCall((err, val) => {
+    assert.ok(!err);
+    assert.strictEqual(val, 'HELLOWORLD');
+  }));
+}
+
+{
+  // AsyncIterable destination is returned and finalizes.
+
+  const ret = pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+  }, async function*(source) {
+    for await (const chunk of source) {
+      chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err, undefined);
+  }));
+  ret.resume();
+  assert.strictEqual(typeof ret.pipe, 'function');
+}
+
+{
+  // AsyncFunction destination is not returned and error is
+  // propagated.
+
+  const ret = pipeline(async function*() {
+    await Promise.resolve();
+    throw new Error('kaboom');
+  }, async function*(source) {
+    for await (const chunk of source) {
+      chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+  }));
+  ret.resume();
+  assert.strictEqual(typeof ret.pipe, 'function');
+}
+
+{
+  const s = new PassThrough();
+  pipeline(async function*() {
+    throw new Error('kaboom');
+  }, s, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  const s = new PassThrough();
+  pipeline(async function*() {
+    throw new Error('kaboom');
+  }(), s, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  const s = new PassThrough();
+  pipeline(function*() {
+    throw new Error('kaboom');
+  }, s, common.mustCall((err, val) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  const s = new PassThrough();
+  pipeline(function*() {
+    throw new Error('kaboom');
+  }(), s, common.mustCall((err, val) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  const s = new PassThrough();
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, s, async function(source) {
+    for await (const chunk of source) {
+      chunk;
+      throw new Error('kaboom');
+    }
+  }, common.mustCall((err, val) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  const s = new PassThrough();
+  const ret = pipeline(function() {
+    return ['hello', 'world'];
+  }, s, async function*(source) {
+    for await (const chunk of source) {
+      chunk;
+      throw new Error('kaboom');
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(s.destroyed, true);
+  }));
+  ret.resume();
+  assert.strictEqual(typeof ret.pipe, 'function');
+}
+
+{
+  // Legacy streams without async iterator.
+
+  const s = new PassThrough();
+  s.push('asd');
+  s.push(null);
+  s[Symbol.asyncIterator] = null;
+  let ret = '';
+  pipeline(s, async function(source) {
+    for await (const chunk of source) {
+      ret += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err, undefined);
+    assert.strictEqual(ret, 'asd');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  // v1 streams without read().
+
+  const s = new Stream();
+  process.nextTick(() => {
+    s.emit('data', 'asd');
+    s.emit('end');
+  });
+  s.close = common.mustCall();
+  let ret = '';
+  pipeline(s, async function(source) {
+    for await (const chunk of source) {
+      ret += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err, undefined);
+    assert.strictEqual(ret, 'asd');
+    assert.strictEqual(s.destroyed, true);
+  }));
+}
+
+{
+  // v1 error streams without read().
+
+  const s = new Stream();
+  process.nextTick(() => {
+    s.emit('error', new Error('kaboom'));
+  });
+  s.destroy = common.mustCall();
+  pipeline(s, async function(source) {
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+  }));
+}
+
+{
+  const s = new PassThrough();
+  assert.throws(() => {
+    pipeline(function(source) {
+    }, s, () => {});
+  }, (err) => {
+    assert.strictEqual(err.code, 'ERR_INVALID_RETURN_VALUE');
+    assert.strictEqual(s.destroyed, false);
+    return true;
+  });
+}
+
+{
+  const s = new PassThrough();
+  assert.throws(() => {
+    pipeline(s, function(source) {
+    }, s, () => {});
+  }, (err) => {
+    assert.strictEqual(err.code, 'ERR_INVALID_RETURN_VALUE');
+    assert.strictEqual(s.destroyed, false);
+    return true;
+  });
+}
+
+{
+  const s = new PassThrough();
+  assert.throws(() => {
+    pipeline(s, function(source) {
+    }, () => {});
+  }, (err) => {
+    assert.strictEqual(err.code, 'ERR_INVALID_RETURN_VALUE');
+    assert.strictEqual(s.destroyed, false);
+    return true;
+  });
+}
+
+{
+  const s = new PassThrough();
+  assert.throws(() => {
+    pipeline(s, function*(source) {
+    }, () => {});
+  }, (err) => {
+    assert.strictEqual(err.code, 'ERR_INVALID_RETURN_VALUE');
+    assert.strictEqual(s.destroyed, false);
+    return true;
+  });
+}
+
+{
+  let res = '';
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, new Transform({
+    transform(chunk, encoding, cb) {
+      cb(new Error('kaboom'));
+    }
+  }), async function(source) {
+    for await (const chunk of source) {
+      res += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(res, '');
+  }));
+}
+
+{
+  let res = '';
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, new Transform({
+    transform(chunk, encoding, cb) {
+      process.nextTick(cb, new Error('kaboom'));
+    }
+  }), async function(source) {
+    for await (const chunk of source) {
+      res += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+    assert.strictEqual(res, '');
+  }));
+}
+
+{
+  let res = '';
+  pipeline(async function*() {
+    await Promise.resolve();
+    yield 'hello';
+    yield 'world';
+  }, new Transform({
+    decodeStrings: false,
+    transform(chunk, encoding, cb) {
+      cb(null, chunk.toUpperCase());
+    }
+  }), async function(source) {
+    for await (const chunk of source) {
+      res += chunk;
+    }
+  }, common.mustCall((err) => {
+    assert.ok(!err);
+    assert.strictEqual(res, 'HELLOWORLD');
+  }));
+}
+
+{
+  // Ensure no unhandled rejection from async function.
+
+  pipeline(async function*() {
+    yield 'hello';
+  }, async function(source) {
+    throw new Error('kaboom');
+  }, common.mustCall((err) => {
+    assert.strictEqual(err.message, 'kaboom');
+  }));
+}
diff --git a/tools/doc/type-parser.js b/tools/doc/type-parser.js
index add331016c2204..02b59d37ffd278 100644
--- a/tools/doc/type-parser.js
+++ b/tools/doc/type-parser.js
@@ -28,6 +28,8 @@ const customTypesMap = {
 
   'AsyncIterator': 'https://tc39.github.io/ecma262/#sec-asynciterator-interface',
 
+  'AsyncIterable': 'https://tc39.github.io/ecma262/#sec-asynciterable-interface',
+
   'bigint': `${jsDocPrefix}Reference/Global_Objects/BigInt`,
 
   'Iterable':