diff --git a/doc/api/cli.md b/doc/api/cli.md
index c657a0715e19b1..478e831dfe67c4 100644
--- a/doc/api/cli.md
+++ b/doc/api/cli.md
@@ -587,6 +587,15 @@ added: v7.10.0
 
 This option is a no-op. It is kept for compatibility.
 
+### `--no-addons`
+<!-- YAML
+added: REPLACEME
+-->
+
+Disable the `node-addons` exports condition as well as disable loading
+native addons. When `--no-addons` is specified, calling `process.dlopen` or
+requiring a native C++ addon will fail and throw an exception.
+
 ### `--no-deprecation`
 <!-- YAML
 added: v0.8.0
@@ -1357,6 +1366,7 @@ Node.js options that are allowed are:
 * `--inspect`
 * `--max-http-header-size`
 * `--napi-modules`
+* `--no-addons`
 * `--no-deprecation`
 * `--no-force-async-hooks-checks`
 * `--no-warnings`
diff --git a/doc/api/errors.md b/doc/api/errors.md
index fc30497feaf545..e8d3b0d3a0dcd7 100644
--- a/doc/api/errors.md
+++ b/doc/api/errors.md
@@ -876,6 +876,14 @@ An unknown cipher was specified.
 An unknown Diffie-Hellman group name was given. See
 [`crypto.getDiffieHellman()`][] for a list of valid group names.
 
+<a id="ERR_DLOPEN_DISABLED"></a>
+### `ERR_DLOPEN_DISABLED`
+<!-- YAML
+added: REPLACEME
+-->
+
+Loading native addons has been disabled using [`--no-addons`][].
+
 <a id="ERR_DLOPEN_FAILED"></a>
 ### `ERR_DLOPEN_FAILED`
 <!-- YAML
@@ -2599,6 +2607,7 @@ closed.
 [`'uncaughtException'`]: process.md#process_event_uncaughtexception
 [`--disable-proto=throw`]: cli.md#cli_disable_proto_mode
 [`--force-fips`]: cli.md#cli_force_fips
+[`--no-addons`]: cli.md#cli_no_addons
 [`Class: assert.AssertionError`]: assert.md#assert_class_assert_assertionerror
 [`ERR_INVALID_ARG_TYPE`]: #ERR_INVALID_ARG_TYPE
 [`EventEmitter`]: events.md#events_class_eventemitter
diff --git a/doc/api/packages.md b/doc/api/packages.md
index 2cdc146946595e..2e3a731727f888 100644
--- a/doc/api/packages.md
+++ b/doc/api/packages.md
@@ -477,6 +477,11 @@ Node.js implements the following conditions:
 * `"node"` - matches for any Node.js environment. Can be a CommonJS or ES
    module file. _This condition should always come after `"import"` or
    `"require"`._
+* `"node-addons"` - similar to `"node"` and matches for any Node.js environment.
+   This condition can be used to provide an entry point which uses native C++
+   addons as opposed to an entry point which is more universal and doesn't rely
+   on native addons. This condition can be disabled via the
+   [`--no-addons` flag][].
 * `"default"` - the generic fallback that always matches. Can be a CommonJS
    or ES module file. _This condition should always come last._
 
@@ -555,17 +560,23 @@ node --conditions=development main.js
 ```
 
 which would then resolve the `"development"` condition in package imports and
-exports, while resolving the existing `"node"`, `"default"`, `"import"`, and
-`"require"` conditions as appropriate.
+exports, while resolving the existing `"node"`, `"node-addons"`, `"default"`,
+`"import"`, and `"require"` conditions as appropriate.
 
 Any number of custom conditions can be set with repeat flags.
 
 ### Conditions Definitions
 
-The `"import"`, `"require"`, `"node"` and `"default"` conditions are defined
-and implemented in Node.js core,
+The `"import"`, `"require"`, `"node"`, `"node-addons"` and `"default"`
+conditions are defined and implemented in Node.js core,
 [as specified above](#packages_conditional_exports).
 
+The `"node-addons"` condition can be used to provide an entry point which
+uses native C++ addons. However, this condition can be disabled via the
+[`--no-addons` flag][]. When using `"node-addons"`, it's recommended to treat
+`"default"` as an enhancement that provides a more universal entry point, e.g.
+using WebAssembly instead of a native addon.
+
 Other condition strings are unknown to Node.js and thus ignored by default.
 Runtimes or tools other than Node.js can use them at their discretion.
 
@@ -1161,6 +1172,7 @@ This field defines [subpath imports][] for the current package.
 [`"main"`]: #packages_main
 [`"name"`]: #packages_name
 [`"type"`]: #packages_type
+[`--no-addons` flag]: cli.md#cli_no_addons
 [`ERR_PACKAGE_PATH_NOT_EXPORTED`]: errors.md#errors_err_package_path_not_exported
 [`esm`]: https://github.com/standard-things/esm#readme
 [`package.json`]: #packages_node_js_package_json_field_definitions
diff --git a/doc/node.1 b/doc/node.1
index 58465b5b655f8e..3603f2e5a5f072 100644
--- a/doc/node.1
+++ b/doc/node.1
@@ -282,6 +282,11 @@ Silence deprecation warnings.
 Disable runtime checks for `async_hooks`.
 These will still be enabled dynamically when `async_hooks` is enabled.
 .
+.It Fl -no-addons
+Disable the `node-addons` exports condition as well as disable loading native
+addons. When `--no-addons` is specified, calling `process.dlopen` or requiring
+a native C++ addon will fail and throw an exception.
+.
 .It Fl -no-warnings
 Silence all process warnings (including deprecations).
 .
diff --git a/lib/internal/modules/cjs/helpers.js b/lib/internal/modules/cjs/helpers.js
index 94602b5309efff..8a703c46cea39b 100644
--- a/lib/internal/modules/cjs/helpers.js
+++ b/lib/internal/modules/cjs/helpers.js
@@ -29,8 +29,16 @@ let debug = require('internal/util/debuglog').debuglog('module', (fn) => {
   debug = fn;
 });
 
+const noAddons = getOptionValue('--no-addons');
+const addonConditions = noAddons ? [] : ['node-addons'];
+
 // TODO: Use this set when resolving pkg#exports conditions in loader.js.
-const cjsConditions = new SafeSet(['require', 'node', ...userConditions]);
+const cjsConditions = new SafeSet([
+  'require',
+  'node',
+  ...addonConditions,
+  ...userConditions,
+]);
 
 function loadNativeModule(filename, request) {
   const mod = NativeModule.map.get(filename);
diff --git a/lib/internal/modules/esm/resolve.js b/lib/internal/modules/esm/resolve.js
index 87f28d5287612a..797ce4f79700e7 100644
--- a/lib/internal/modules/esm/resolve.js
+++ b/lib/internal/modules/esm/resolve.js
@@ -57,7 +57,16 @@ const { Module: CJSModule } = require('internal/modules/cjs/loader');
 
 const packageJsonReader = require('internal/modules/package_json_reader');
 const userConditions = getOptionValue('--conditions');
-const DEFAULT_CONDITIONS = ObjectFreeze(['node', 'import', ...userConditions]);
+const noAddons = getOptionValue('--no-addons');
+const addonConditions = noAddons ? [] : ['node-addons'];
+
+const DEFAULT_CONDITIONS = ObjectFreeze([
+  'node',
+  'import',
+  ...addonConditions,
+  ...userConditions,
+]);
+
 const DEFAULT_CONDITIONS_SET = new SafeSet(DEFAULT_CONDITIONS);
 
 const pendingDeprecation = getOptionValue('--pending-deprecation');
diff --git a/src/env-inl.h b/src/env-inl.h
index 533a8284e9a187..c4b64d77d9e094 100644
--- a/src/env-inl.h
+++ b/src/env-inl.h
@@ -890,6 +890,11 @@ inline bool Environment::is_main_thread() const {
   return worker_context() == nullptr;
 }
 
+inline bool Environment::no_native_addons() const {
+  return (flags_ & EnvironmentFlags::kNoNativeAddons) ||
+          !options_->allow_native_addons;
+}
+
 inline bool Environment::should_not_register_esm_loader() const {
   return flags_ & EnvironmentFlags::kNoRegisterESMLoader;
 }
diff --git a/src/env.h b/src/env.h
index b6967afb899114..824202ef5258e4 100644
--- a/src/env.h
+++ b/src/env.h
@@ -1054,6 +1054,7 @@ class Environment : public MemoryRetainer {
   inline void set_has_serialized_options(bool has_serialized_options);
 
   inline bool is_main_thread() const;
+  inline bool no_native_addons() const;
   inline bool should_not_register_esm_loader() const;
   inline bool owns_process_state() const;
   inline bool owns_inspector() const;
diff --git a/src/node.h b/src/node.h
index 8d4ec2276b1990..9092899d70b968 100644
--- a/src/node.h
+++ b/src/node.h
@@ -428,7 +428,13 @@ enum Flags : uint64_t {
   // Set this flag to force hiding console windows when spawning child
   // processes. This is usually used when embedding Node.js in GUI programs on
   // Windows.
-  kHideConsoleWindows = 1 << 5
+  kHideConsoleWindows = 1 << 5,
+  // Set this flag to disable loading native addons via `process.dlopen`.
+  // This environment flag is especially important for worker threads
+  // so that a worker thread can't load a native addon even if `execArgv`
+  // is overwritten and `--no-addons` is not specified but was specified
+  // for this Environment instance.
+  kNoNativeAddons = 1 << 6
 };
 }  // namespace EnvironmentFlags
 
diff --git a/src/node_binding.cc b/src/node_binding.cc
index 8b34d601146579..d47b161f87597c 100644
--- a/src/node_binding.cc
+++ b/src/node_binding.cc
@@ -413,6 +413,12 @@ inline napi_addon_register_func GetNapiInitializerCallback(DLib* dlib) {
 // cache that's a plain C list or hash table that's shared across contexts?
 void DLOpen(const FunctionCallbackInfo<Value>& args) {
   Environment* env = Environment::GetCurrent(args);
+
+  if (env->no_native_addons()) {
+    return THROW_ERR_DLOPEN_DISABLED(
+      env, "Cannot load native addon because loading addons is disabled.");
+  }
+
   auto context = env->context();
 
   CHECK_NULL(thread_local_modpending);
diff --git a/src/node_errors.h b/src/node_errors.h
index 7b67c4e9eb95b7..1ca93c16ddf790 100644
--- a/src/node_errors.h
+++ b/src/node_errors.h
@@ -38,6 +38,7 @@ void OnFatalError(const char* location, const char* message);
   V(ERR_CRYPTO_TIMING_SAFE_EQUAL_LENGTH, RangeError)                           \
   V(ERR_CRYPTO_UNKNOWN_CIPHER, Error)                                          \
   V(ERR_CRYPTO_UNKNOWN_DH_GROUP, Error)                                        \
+  V(ERR_DLOPEN_DISABLED, Error)                                                \
   V(ERR_DLOPEN_FAILED, Error)                                                  \
   V(ERR_EXECUTION_ENVIRONMENT_NOT_AVAILABLE, Error)                            \
   V(ERR_INVALID_ADDRESS, Error)                                                \
diff --git a/src/node_options.cc b/src/node_options.cc
index bc1ec5558aac44..06847ce3323dee 100644
--- a/src/node_options.cc
+++ b/src/node_options.cc
@@ -387,6 +387,11 @@ EnvironmentOptionsParser::EnvironmentOptionsParser() {
             &EnvironmentOptions::force_async_hooks_checks,
             kAllowedInEnvironment,
             true);
+  AddOption("--addons",
+            "disable loading native addons",
+            &EnvironmentOptions::allow_native_addons,
+            kAllowedInEnvironment,
+            true);
   AddOption("--warnings",
             "silence all process warnings",
             &EnvironmentOptions::warnings,
diff --git a/src/node_options.h b/src/node_options.h
index 8d86f134ff9c73..8a067aeeadf5c4 100644
--- a/src/node_options.h
+++ b/src/node_options.h
@@ -122,6 +122,7 @@ class EnvironmentOptions : public Options {
   uint64_t max_http_header_size = 16 * 1024;
   bool deprecation = true;
   bool force_async_hooks_checks = true;
+  bool allow_native_addons = true;
   bool warnings = true;
   bool force_context_aware = false;
   bool pending_deprecation = false;
diff --git a/src/node_worker.cc b/src/node_worker.cc
index 600b888d415e1c..388b070878e80f 100644
--- a/src/node_worker.cc
+++ b/src/node_worker.cc
@@ -607,6 +607,8 @@ void Worker::New(const FunctionCallbackInfo<Value>& args) {
     worker->environment_flags_ |= EnvironmentFlags::kTrackUnmanagedFds;
   if (env->hide_console_windows())
     worker->environment_flags_ |= EnvironmentFlags::kHideConsoleWindows;
+  if (env->no_native_addons())
+    worker->environment_flags_ |= EnvironmentFlags::kNoNativeAddons;
 }
 
 void Worker::StartThread(const FunctionCallbackInfo<Value>& args) {
diff --git a/test/addons/no-addons/binding.gyp b/test/addons/no-addons/binding.gyp
new file mode 100644
index 00000000000000..77f2fced5a3406
--- /dev/null
+++ b/test/addons/no-addons/binding.gyp
@@ -0,0 +1,9 @@
+{
+  'targets': [
+    {
+      'target_name': 'binding',
+      'sources': [ '../hello-world/binding.cc' ],
+      'includes': ['../common.gypi'],
+    }
+  ]
+}
diff --git a/test/addons/no-addons/test-worker.js b/test/addons/no-addons/test-worker.js
new file mode 100644
index 00000000000000..2a89cef3e2736d
--- /dev/null
+++ b/test/addons/no-addons/test-worker.js
@@ -0,0 +1,59 @@
+// Flags: --no-addons
+
+'use strict';
+
+const common = require('../../common');
+const assert = require('assert');
+const path = require('path');
+const { Worker } = require('worker_threads');
+
+const binding = path.resolve(__dirname, `./build/${common.buildType}/binding`);
+
+const assertError = (error) => {
+  assert.strictEqual(error.code, 'ERR_DLOPEN_DISABLED');
+  assert.strictEqual(
+    error.message,
+    'Cannot load native addon because loading addons is disabled.'
+  );
+};
+
+{
+  // Flags should be inherited
+  const worker = new Worker(`require(${JSON.stringify(binding)})`, {
+    eval: true,
+  });
+
+  worker.on('error', common.mustCall(assertError));
+}
+
+{
+  // Should throw when using `process.dlopen` directly
+  const worker = new Worker(
+    `process.dlopen({ exports: {} }, ${JSON.stringify(binding)});`,
+    {
+      eval: true,
+    }
+  );
+
+  worker.on('error', common.mustCall(assertError));
+}
+
+{
+  // Explicitly pass `--no-addons`
+  const worker = new Worker(`require(${JSON.stringify(binding)})`, {
+    eval: true,
+    execArgv: ['--no-addons'],
+  });
+
+  worker.on('error', common.mustCall(assertError));
+}
+
+{
+  // If `execArgv` is overwritten it should still fail to load addons
+  const worker = new Worker(`require(${JSON.stringify(binding)})`, {
+    eval: true,
+    execArgv: [],
+  });
+
+  worker.on('error', common.mustCall(assertError));
+}
diff --git a/test/addons/no-addons/test.js b/test/addons/no-addons/test.js
new file mode 100644
index 00000000000000..063dd3491e36fc
--- /dev/null
+++ b/test/addons/no-addons/test.js
@@ -0,0 +1,43 @@
+// Flags: --no-addons
+
+'use strict';
+
+const common = require('../../common');
+const assert = require('assert');
+
+const bindingPath = require.resolve(`./build/${common.buildType}/binding`);
+
+const assertError = (error) => {
+  assert(error instanceof Error);
+  assert.strictEqual(error.code, 'ERR_DLOPEN_DISABLED');
+  assert.strictEqual(
+    error.message,
+    'Cannot load native addon because loading addons is disabled.'
+  );
+};
+
+{
+  let threw = false;
+
+  try {
+    require(bindingPath);
+  } catch (error) {
+    assertError(error);
+    threw = true;
+  }
+
+  assert(threw);
+}
+
+{
+  let threw = false;
+
+  try {
+    process.dlopen({ exports: {} }, bindingPath);
+  } catch (error) {
+    assertError(error);
+    threw = true;
+  }
+
+  assert(threw);
+}
diff --git a/test/es-module/test-esm-no-addons.mjs b/test/es-module/test-esm-no-addons.mjs
new file mode 100644
index 00000000000000..a61c1f3b7cb7d2
--- /dev/null
+++ b/test/es-module/test-esm-no-addons.mjs
@@ -0,0 +1,27 @@
+import { mustCall } from '../common/index.mjs';
+import { Worker, isMainThread } from 'worker_threads';
+import assert from 'assert';
+import { fileURLToPath } from 'url';
+import { requireFixture, importFixture } from '../fixtures/pkgexports.mjs';
+
+if (isMainThread) {
+  const tests = [[], ['--no-addons']];
+
+  for (const execArgv of tests) {
+    new Worker(fileURLToPath(import.meta.url), { execArgv });
+  }
+} else {
+  [requireFixture, importFixture].forEach((loadFixture) => {
+    loadFixture('pkgexports/no-addons').then(
+      mustCall((module) => {
+        const message = module.default;
+
+        if (process.execArgv.length === 0) {
+          assert.strictEqual(message, 'using native addons');
+        } else {
+          assert.strictEqual(message, 'not using native addons');
+        }
+      })
+    );
+  });
+}
diff --git a/test/fixtures/es-module-loaders/loader-with-custom-condition.mjs b/test/fixtures/es-module-loaders/loader-with-custom-condition.mjs
index 78ffd75e6be27b..3aefed51d57d3e 100644
--- a/test/fixtures/es-module-loaders/loader-with-custom-condition.mjs
+++ b/test/fixtures/es-module-loaders/loader-with-custom-condition.mjs
@@ -1,8 +1,14 @@
-import {ok, deepStrictEqual} from 'assert';
+import { ok, deepStrictEqual } from 'assert';
 
 export async function resolve(specifier, context, defaultResolve) {
   ok(Array.isArray(context.conditions), 'loader receives conditions array');
-  deepStrictEqual([...context.conditions].sort(), ['import', 'node']);
+
+  deepStrictEqual([...context.conditions].sort(), [
+    'import',
+    'node',
+    'node-addons',
+  ]);
+
   return defaultResolve(specifier, {
     ...context,
     conditions: ['custom-condition', ...context.conditions],
diff --git a/test/fixtures/node_modules/pkgexports/addons-entry.js b/test/fixtures/node_modules/pkgexports/addons-entry.js
new file mode 100644
index 00000000000000..6487c639f4307c
--- /dev/null
+++ b/test/fixtures/node_modules/pkgexports/addons-entry.js
@@ -0,0 +1,3 @@
+'use strict';
+
+module.exports = 'using native addons';
diff --git a/test/fixtures/node_modules/pkgexports/no-addons-entry.js b/test/fixtures/node_modules/pkgexports/no-addons-entry.js
new file mode 100644
index 00000000000000..85096c5aab8e33
--- /dev/null
+++ b/test/fixtures/node_modules/pkgexports/no-addons-entry.js
@@ -0,0 +1,3 @@
+'use strict';
+
+module.exports = 'not using native addons';
diff --git a/test/fixtures/node_modules/pkgexports/package.json b/test/fixtures/node_modules/pkgexports/package.json
index 6c80d5cb15a67e..7f8f994ac398bd 100644
--- a/test/fixtures/node_modules/pkgexports/package.json
+++ b/test/fixtures/node_modules/pkgexports/package.json
@@ -20,6 +20,10 @@
     "./nofallback1": [],
     "./nofallback2": [null, {}, "builtin:x"],
     "./nodemodules": "./node_modules/internalpkg/x.js",
+    "./no-addons": {
+      "node-addons": "./addons-entry.js",
+      "default": "./no-addons-entry.js"
+    },
     "./condition": [{
       "custom-condition": {
         "import": "./custom-condition.mjs",
diff --git a/test/parallel/test-no-addons-resolution-condition.js b/test/parallel/test-no-addons-resolution-condition.js
new file mode 100644
index 00000000000000..b9c4e9de3a5e85
--- /dev/null
+++ b/test/parallel/test-no-addons-resolution-condition.js
@@ -0,0 +1,31 @@
+'use strict';
+
+const common = require('../common');
+const fixtures = require('../common/fixtures');
+const { Worker, isMainThread, parentPort } = require('worker_threads');
+const assert = require('assert');
+const { createRequire } = require('module');
+
+const loadFixture = createRequire(fixtures.path('node_modules'));
+
+if (isMainThread) {
+  const tests = [[], ['--no-addons']];
+
+  for (const execArgv of tests) {
+    const worker = new Worker(__filename, { execArgv });
+
+    worker.on(
+      'message',
+      common.mustCall((message) => {
+        if (execArgv.length === 0) {
+          assert.strictEqual(message, 'using native addons');
+        } else {
+          assert.strictEqual(message, 'not using native addons');
+        }
+      })
+    );
+  }
+} else {
+  const message = loadFixture('pkgexports/no-addons');
+  parentPort.postMessage(message);
+}