diff --git a/src/node_messaging.cc b/src/node_messaging.cc
index b743ec72b45ee2..097696f8136a13 100644
--- a/src/node_messaging.cc
+++ b/src/node_messaging.cc
@@ -964,7 +964,7 @@ void MessagePort::PostMessage(const FunctionCallbackInfo<Value>& args) {
   // Even if the backing MessagePort object has already been deleted, we still
   // want to serialize the message to ensure spec-compliant behavior w.r.t.
   // transfers.
-  if (port == nullptr) {
+  if (port == nullptr || port->IsHandleClosing()) {
     Message msg;
     USE(msg.Serialize(env, context, args[0], transfer_list, obj));
     return;
diff --git a/test/parallel/test-worker-message-port-close.js b/test/parallel/test-worker-message-port-close.js
index 6abc01d1b7b568..6562824d6a9ed3 100644
--- a/test/parallel/test-worker-message-port-close.js
+++ b/test/parallel/test-worker-message-port-close.js
@@ -39,3 +39,11 @@ function dummy() {}
     message: 'Cannot send data on closed MessagePort'
   });
 }
+
+// Refs: https://github.com/nodejs/node/issues/42296
+{
+  const ch = new MessageChannel();
+  ch.port1.onmessage = common.mustNotCall();
+  ch.port2.close();
+  ch.port2.postMessage('fhqwhgads');
+}