diff --git a/lib/internal/bootstrap/pre_execution.js b/lib/internal/bootstrap/pre_execution.js
index 0262497747fc23..da4c2d2a2adeaa 100644
--- a/lib/internal/bootstrap/pre_execution.js
+++ b/lib/internal/bootstrap/pre_execution.js
@@ -168,7 +168,8 @@ function setupFetch() {
 // TODO(aduh95): move this to internal/bootstrap/browser when the CLI flag is
 //               removed.
 function setupWebCrypto() {
-  if (!getOptionValue('--experimental-global-webcrypto')) {
+  if (process.config.variables.node_no_browser_globals ||
+      !getOptionValue('--experimental-global-webcrypto')) {
     return;
   }