diff --git a/configure.py b/configure.py
index 8be9e9ca5c4af8..33671a034290df 100755
--- a/configure.py
+++ b/configure.py
@@ -2121,6 +2121,17 @@ def make_bin_override():
 gyp_args = ['--no-parallel', '-Dconfiguring_node=1']
 gyp_args += ['-Dbuild_type=' + config['BUILDTYPE']]
 
+# Remove the trailing .exe from the executable name, otherwise the python.exe
+# would be rewrote as python_host.exe due to hack in GYP for supporting cross
+# compilation on Windows.
+# See https://github.com/nodejs/node/pull/32867 for related change.
+python = sys.executable
+if flavor == 'win' and python.lower().endswith('.exe'):
+  python = python[:-4]
+# Always set 'python' variable, otherwise environments that only have python3
+# will fail to run python scripts.
+gyp_args += ['-Dpython=' + python]
+
 if options.use_ninja:
   gyp_args += ['-f', 'ninja-' + flavor]
 elif flavor == 'win' and sys.platform != 'msys':
@@ -2133,10 +2144,6 @@ def make_bin_override():
   os.path.islink('./compile_commands.json') and os.unlink('./compile_commands.json')
   os.symlink('./out/' + config['BUILDTYPE'] + '/compile_commands.json', './compile_commands.json')
 
-# override the variable `python` defined in common.gypi
-if bin_override is not None:
-  gyp_args += ['-Dpython=' + sys.executable]
-
 # pass the leftover non-whitespace positional arguments to GYP
 gyp_args += [arg for arg in args if not str.isspace(arg)]
 
diff --git a/node.gyp b/node.gyp
index 93e4235a0f3efd..3f6915b266fc38 100644
--- a/node.gyp
+++ b/node.gyp
@@ -762,7 +762,7 @@
                 '<(fipsmodule)',
               ],
               'action': [
-                'python', 'tools/copyfile.py',
+                '<(python)', 'tools/copyfile.py',
                 '<(fipsmodule_internal)',
                 '<(fipsmodule)',
               ],
@@ -772,7 +772,7 @@
               'inputs': [ '<(opensslconfig)', ],
               'outputs': [ '<(opensslconfig_internal)', ],
               'action': [
-                'python', 'tools/enable_fips_include.py',
+                '<(python)', 'tools/enable_fips_include.py',
                 '<(opensslconfig)',
                 '<(opensslconfig_internal)',
                 '<(fipsconfig)',
diff --git a/tools/gyp/pylib/gyp/generator/msvs.py b/tools/gyp/pylib/gyp/generator/msvs.py
index fd950057847980..568109035ed976 100644
--- a/tools/gyp/pylib/gyp/generator/msvs.py
+++ b/tools/gyp/pylib/gyp/generator/msvs.py
@@ -438,6 +438,7 @@ def _BuildCommandLineForRuleRaw(
             # Support a mode for using cmd directly.
             # Convert any paths to native form (first element is used directly).
             # TODO(quote):  regularize quoting path names throughout the module
+            command[1] = '"%s"' % command[1]
             arguments = ['"%s"' % i for i in arguments]
         # Collapse into a single command.
         return input_dir_preamble + " ".join(command + arguments)
diff --git a/tools/v8_gypfiles/toolchain.gypi b/tools/v8_gypfiles/toolchain.gypi
index bcecdb21aeb368..b311c04d29281f 100644
--- a/tools/v8_gypfiles/toolchain.gypi
+++ b/tools/v8_gypfiles/toolchain.gypi
@@ -41,7 +41,7 @@
     'has_valgrind%': 0,
     'coverage%': 0,
     'v8_target_arch%': '<(target_arch)',
-    'v8_host_byteorder%': '<!(python -c "import sys; print(sys.byteorder)")',
+    'v8_host_byteorder%': '<!("<(python)" -c "import sys; print(sys.byteorder)")',
     'force_dynamic_crt%': 0,
 
     # Setting 'v8_can_use_vfp32dregs' to 'true' will cause V8 to use the VFP