diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index ffa194d014c12..0e9edb5f5ef31 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -58,7 +58,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        node-version: [10.x, 12.x, 14.x, 16.x]
+        node-version: [12.x, 14.x, 16.x]
         platform:
           - os: ubuntu-latest
             shell: bash
@@ -100,7 +100,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        node-version: [10.x, 12.x, 14.x, 16.x]
+        node-version: [12.x, 14.x, 16.x]
         platform:
           - os: ubuntu-latest
             shell: bash
@@ -141,7 +141,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        node-version: ['10.1', 10.x, '12.1', 12.x, '14.1', 14.x, '16.1', 16.x]
+        node-version: ['12.13.0', 12.x, '14.15.0', 14.x, '16.1', 16.x]
         platform:
           - os: ubuntu-latest
             shell: bash
diff --git a/lib/npm.js b/lib/npm.js
index 966d11210c275..15a7a4859731e 100644
--- a/lib/npm.js
+++ b/lib/npm.js
@@ -358,3 +358,5 @@ const npm = module.exports = new class extends EventEmitter {
 
 if (require.main === module)
   require('./cli.js')(process)
+else
+  throw new Error('The programmatic API was removed in npm v8.0.0')
diff --git a/package.json b/package.json
index 8011f238ac2ff..b76dff0cc9079 100644
--- a/package.json
+++ b/package.json
@@ -235,6 +235,6 @@
   },
   "license": "Artistic-2.0",
   "engines": {
-    "node": ">=10"
+    "node": "^12.13.0 || ^14.15.0 || >=16"
   }
 }
diff --git a/test/lib/utils/unsupported.js b/test/lib/utils/unsupported.js
index 3a05d90666025..4d806cefc4e52 100644
--- a/test/lib/utils/unsupported.js
+++ b/test/lib/utils/unsupported.js
@@ -27,10 +27,15 @@ const versions = [
   ['v7.2.3', false, true],
   ['v8.4.0', false, true],
   ['v9.3.0', false, true],
-  ['v10.0.0-0', false, false],
-  ['v11.0.0-0', false, false],
-  ['v12.0.0-0', false, false],
-  ['v13.0.0-0', false, false],
+  ['v10.0.0-0', false, true],
+  ['v11.0.0-0', false, true],
+  ['v12.0.0-0', false, true],
+  ['v12.13.0-0', false, false],
+  ['v13.0.0-0', false, true],
+  ['v14.0.0-0', false, true],
+  ['v14.15.0-0', false, false],
+  ['v15.0.0-0', false, true],
+  ['v16.0.0-0', false, false],
 ]
 
 t.test('versions', function (t) {