diff --git a/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts b/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
index d03afadb93..f631f001ee 100644
--- a/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
+++ b/packages/opentelemetry-instrumentation/src/platform/node/instrumentation.ts
@@ -59,6 +59,18 @@ export abstract class InstrumentationBase<T = any>
     }
   }
 
+  private _extractPackageVersion(baseDir: string): string | undefined {
+    try {
+      // eslint-disable-next-line @typescript-eslint/no-var-requires
+      const version = require(path.join(baseDir, 'package.json')).version;
+      return typeof version === 'string' ? version : undefined;
+    } catch (error) {
+      diag.warn('Failed extracting version', baseDir);
+    }
+    
+    return undefined;
+  }
+
   private _onRequire<T>(
     module: InstrumentationModuleDefinition<T>,
     exports: T,
@@ -73,13 +85,11 @@ export abstract class InstrumentationBase<T = any>
       return exports;
     }
 
-    // eslint-disable-next-line @typescript-eslint/no-var-requires
-    const version = require(path.join(baseDir, 'package.json')).version;
+    const version = this._extractPackageVersion(baseDir);
     module.moduleVersion = version;
     if (module.name === name) {
       // main module
       if (
-        typeof version === 'string' &&
         isSupported(module.supportedVersions, version, module.includePrerelease)
       ) {
         if (typeof module.patch === 'function') {
@@ -167,7 +177,12 @@ export abstract class InstrumentationBase<T = any>
   }
 }
 
-function isSupported(supportedVersions: string[], version: string, includePrerelease?: boolean): boolean {
+function isSupported(supportedVersions: string[], version?: string, includePrerelease?: boolean): boolean {
+  if (typeof version === 'undefined') {
+    // If we don't have the version, accept the wildcard case only
+    return supportedVersions.includes('*');
+  }
+
   return supportedVersions.some(supportedVersion => {
     return satisfies(version, supportedVersion, { includePrerelease });
   });
diff --git a/packages/opentelemetry-instrumentation/test/node/InstrumentationBase.test.ts b/packages/opentelemetry-instrumentation/test/node/InstrumentationBase.test.ts
new file mode 100644
index 0000000000..e1c42681d3
--- /dev/null
+++ b/packages/opentelemetry-instrumentation/test/node/InstrumentationBase.test.ts
@@ -0,0 +1,166 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+import * as assert from 'assert';
+import * as sinon from 'sinon';
+import { InstrumentationBase, InstrumentationModuleDefinition } from '../../src';
+
+const MODULE_NAME = 'test-module';
+const MODULE_FILE_NAME = 'test-module-file';
+const MODULE_VERSION = '0.1.0';
+const WILDCARD_VERSION = '*';
+const MODULE_DIR = '/random/dir';
+
+class TestInstrumentation extends InstrumentationBase {
+  constructor() {
+    super(MODULE_NAME, MODULE_VERSION);
+  }
+
+  init() {}
+}
+
+describe('InstrumentationBase', () => {
+  describe('_onRequire - module version is not available', () => {
+    // For all of these cases, there is no indication of the actual module version,
+    // so we require there to be a wildcard supported version.
+
+    let instrumentation: TestInstrumentation;
+    let modulePatchSpy: sinon.SinonSpy;
+  
+    beforeEach(() => {
+      instrumentation = new TestInstrumentation();
+      // @ts-expect-error access internal property for testing
+      instrumentation._enabled = true;
+      modulePatchSpy = sinon.spy();
+    });
+    
+    describe('when patching a module', () => {
+      describe('AND there is no wildcard supported version', () => {
+        it('should not patch module', () => {
+          const moduleExports = {};
+          const instrumentationModule = {
+            supportedVersions: [`^${MODULE_VERSION}`],
+            name: MODULE_NAME,
+            patch: modulePatchSpy as unknown,
+          } as InstrumentationModuleDefinition<unknown>;
+  
+          // @ts-expect-error access internal property for testing
+          instrumentation._onRequire<unknown>(
+            instrumentationModule,
+            moduleExports,
+            MODULE_NAME,
+            MODULE_DIR
+          );
+      
+          assert.strictEqual(instrumentationModule.moduleVersion, undefined);
+          assert.strictEqual(instrumentationModule.moduleExports, undefined);
+          sinon.assert.notCalled(modulePatchSpy);
+        });
+      });
+
+      describe('AND there is a wildcard supported version', () => {
+        it('should patch module', () => {
+          const moduleExports = {};
+          const instrumentationModule = {
+            supportedVersions: [`^${MODULE_VERSION}`, WILDCARD_VERSION],
+            name: MODULE_NAME,
+            patch: modulePatchSpy as unknown,
+          } as InstrumentationModuleDefinition<unknown>;
+          
+          // @ts-expect-error access internal property for testing
+          instrumentation._onRequire<unknown>(
+            instrumentationModule,
+            moduleExports,
+            MODULE_NAME,
+            MODULE_DIR
+          );
+          
+          assert.strictEqual(instrumentationModule.moduleVersion, undefined);
+          assert.strictEqual(instrumentationModule.moduleExports, moduleExports);
+          sinon.assert.calledOnceWithExactly(modulePatchSpy, moduleExports, undefined);
+        });
+      });
+    });
+      
+    describe('when patching module files', () => {
+      let filePatchSpy: sinon.SinonSpy;
+
+      beforeEach(() => {
+        filePatchSpy = sinon.spy();
+      })
+
+      describe('AND there is no wildcard supported version', () => {
+        it('should not patch module file', () => {
+          const moduleExports = {};
+          const supportedVersions = [`^${MODULE_VERSION}`];
+          const instrumentationModule = {
+            supportedVersions,
+            name: MODULE_NAME,
+            patch: modulePatchSpy as unknown,
+            files: [{
+              name: MODULE_FILE_NAME,
+              supportedVersions,
+              patch: filePatchSpy as unknown
+            }]
+          } as InstrumentationModuleDefinition<unknown>;
+  
+          // @ts-expect-error access internal property for testing
+          instrumentation._onRequire<unknown>(
+            instrumentationModule,
+            moduleExports,
+            MODULE_FILE_NAME,
+            MODULE_DIR
+          );
+      
+          assert.strictEqual(instrumentationModule.moduleVersion, undefined);
+          assert.strictEqual(instrumentationModule.moduleExports, undefined);
+          sinon.assert.notCalled(modulePatchSpy);
+          sinon.assert.notCalled(filePatchSpy);
+        });
+      });
+
+      describe('AND there is a wildcard supported version', () => {
+        it('should patch module file', () => {
+          const moduleExports = {};
+          const supportedVersions = [`^${MODULE_VERSION}`, WILDCARD_VERSION];
+          const instrumentationModule = {
+            supportedVersions,
+            name: MODULE_NAME,
+            patch: modulePatchSpy as unknown,
+            files: [{
+              name: MODULE_FILE_NAME,
+              supportedVersions,
+              patch: filePatchSpy as unknown
+            }]
+          } as InstrumentationModuleDefinition<unknown>;
+  
+          // @ts-expect-error access internal property for testing
+          instrumentation._onRequire<unknown>(
+            instrumentationModule,
+            moduleExports,
+            MODULE_FILE_NAME,
+            MODULE_DIR
+          );
+      
+          assert.strictEqual(instrumentationModule.moduleVersion, undefined);
+          assert.strictEqual(instrumentationModule.files[0].moduleExports, moduleExports);
+          sinon.assert.notCalled(modulePatchSpy);
+          sinon.assert.calledOnceWithExactly(filePatchSpy, moduleExports, undefined);
+        });
+      });
+    });
+  });
+});