diff --git a/CHANGELOG.md b/CHANGELOG.md
index 4a5cbd50720..f9e64720c14 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -13,6 +13,8 @@ release.
 
 ### Metrics
 
+- Clarify that API support for multi-instrument callbacks is permitted.
+  ([#2263](https://github.com/open-telemetry/opentelemetry-specification/pull/2263)).
 - Clarify SDK behavior when view conflicts are present
   ([#2462](https://github.com/open-telemetry/opentelemetry-specification/pull/2462)).
 - Clarify MetricReader.Collect result
diff --git a/specification/metrics/api.md b/specification/metrics/api.md
index cbcf6d055aa..c1189c8de52 100644
--- a/specification/metrics/api.md
+++ b/specification/metrics/api.md
@@ -45,6 +45,7 @@
     + [Asynchronous UpDownCounter creation](#asynchronous-updowncounter-creation)
     + [Asynchronous UpDownCounter operations](#asynchronous-updowncounter-operations)
 - [Measurement](#measurement)
+  * [Multiple-instrument callbacks](#multiple-instrument-callbacks)
 - [Compatibility requirements](#compatibility-requirements)
 - [Concurrency requirements](#concurrency-requirements)
 
@@ -337,19 +338,26 @@ The API to construct asynchronous instruments MUST accept the following paramete
   rule](#instrument-unit).
 * An optional `description`, following the [instrument description
   rule](#instrument-description).
-* Zero or more `callback` functions.
+* Zero or more `callback` functions, responsible for reporting
+  [Measurement](#measurement) values of the created instrument.
 
 The API MUST support creation of asynchronous instruments by passing
-zero or more callback functions to be permanently registered to the
+zero or more `callback` functions to be permanently registered to the
 newly created instrument.
 
-The API SHOULD support registration of callback functions to
+A Callback is the conceptual entity created each time a `callback`
+function is registered through an OpenTelemetry API.
+
+The API SHOULD support registration of `callback` functions associated with
 asynchronous instruments after they are created.
 
-Where the API supports registration of callback functions after
-asynchronous instrumentation creation, it MUST return something (e.g.,
-a registration handle, receipt or token) to the user that supports
-undoing the effect of callback registation.
+Where the API supports registration of `callback` functions after
+asynchronous instrumentation creation, the user MUST be able to undo
+registration of the specific callback after its registration by some means.
+
+Every currently registered Callback associated with an instrument MUST
+be evaluted exactly once during collection prior to reading data for
+that instrument.
 
 Callback functions MUST be documented as follows for the end user:
 
@@ -366,11 +374,28 @@ RECOMMENDATIONS is explicitly not specified at the API level.
 [OpenTelemetry API](../overview.md#api) authors MAY decide what is the idiomatic
 approach for capturing measurements from callback functions. Here are some examples:
 
-* Return a list (or tuple, generator, enumerator, etc.) of `Measurement`s.
-* Use an observable result argument to allow individual `Measurement`s to be
-  reported.
+* Return a list (or tuple, generator, enumerator, etc.) of individual
+  `Measurement` values.
+* Pass an *Observable Result* as a formal parameter of the callback,
+  where `result.Observe()` captures individual `Measurement` values.
+
+Callbacks registered at the time of instrument creation MUST apply to
+the single instruments which is under construction.
 
-The API MUST treat observations from a single callback as logically
+Callbacks registered after the time of instrument creation MAY be
+associated with multiple instruments.
+
+Idiomatic APIs for multiple-instrument Callbacks MUST distinguish the
+instrument associated with each observed `Measurement` value.
+
+Multiple-instrument Callbacks MUST be associated at the time of
+registration with a declared set of asynchronous instruments from the
+same `Meter` instance.  This requirement that Instruments be
+declaratively associated with Callbacks allows an SDK to execute only
+those Callbacks that are necessary to evaluate instruments that are in
+use by a configured [View](sdk.md#view).
+
+The API MUST treat observations from a single Callback as logically
 taking place at a single instant, such that when recorded,
 observations from a single callback MUST be reported with identical
 timestamps.
@@ -1046,6 +1071,49 @@ for the interaction between the API and SDK.
 * A value
 * [`Attributes`](../common/README.md#attribute)
 
+### Multiple-instrument callbacks
+
+[The Metrics API MAY support an interface allowing the use of multiple
+instruments from a single registered
+Callback](#asynchronous-instrument-api).  The API to register a new
+Callback SHOULD accept:
+
+- A `callback` function
+- A list (or tuple, etc.) of Instruments used in the `callback` function.
+
+It is RECOMMENDED that the API authors use one of the following forms
+for the `callback` function:
+
+* The list (or tuple, etc.) returned by the `callback` function
+  contains `(Instrument, Measurement)` pairs.
+* the Observable Result parameter receives an additional `(Instrument,
+  Measurement)` pairs
+
+This interface is typically a more performant way to report multiple
+measurements when they are obtained through an expensive process, such
+as reading `/proc` files or probing the garbage collection subsystem.
+
+For example,
+
+```Python
+# Python
+class Device:
+    """A device with two instruments"""
+
+    def __init__(self, meter, proeprty):
+        self.property = property
+        self.usage = meter.create_observable_counter(name="usage", description="count of items used")
+        self.pressure = meter.create_observable_gauge(name="pressure", description="force per unit area")
+
+        # Note the two associated instruments are passed to the callback.
+        meter.register_callback([self.usage, self.pressure], self.observe)
+
+    def observe(self, result):
+        usage, pressure = expensive_system_call()
+        result.observe(self.usage, usage, {'property', self.property})
+        result.observe(self.pressure, pressure, {'property', self.property})
+```
+
 ## Compatibility requirements
 
 All the metrics components SHOULD allow new APIs to be added to