diff --git a/.changeset/tidy-seas-dance.md b/.changeset/tidy-seas-dance.md
new file mode 100644
index 00000000000..7a6402fec1c
--- /dev/null
+++ b/.changeset/tidy-seas-dance.md
@@ -0,0 +1,7 @@
+---
+"@pnpm/config": minor
+"@pnpm/core": minor
+"pnpm": minor
+---
+
+When `ignore-compatibility-db` is set to `true`, the [compatibility database](https://github.com/yarnpkg/berry/blob/master/packages/yarnpkg-extensions/sources/index.ts) will not be used to patch dependencies [#5132](https://github.com/pnpm/pnpm/issues/5132).
diff --git a/packages/config/src/Config.ts b/packages/config/src/Config.ts
index 6d93403a720..7e12c041362 100644
--- a/packages/config/src/Config.ts
+++ b/packages/config/src/Config.ts
@@ -28,6 +28,7 @@ export interface Config {
   dir: string
   bin: string
   ignoreScripts?: boolean
+  ignoreCompatibilityDb?: boolean
   includeWorkspaceRoot?: boolean
   save?: boolean
   saveProd?: boolean
diff --git a/packages/config/src/index.ts b/packages/config/src/index.ts
index 8b4ba2a58c2..30a274f7699 100644
--- a/packages/config/src/index.ts
+++ b/packages/config/src/index.ts
@@ -60,6 +60,7 @@ export const types = Object.assign({
   'git-branch-lockfile': Boolean,
   hoist: Boolean,
   'hoist-pattern': Array,
+  'ignore-compatibility-db': Boolean,
   'ignore-pnpmfile': Boolean,
   'ignore-workspace': Boolean,
   'ignore-workspace-root-check': Boolean,
diff --git a/packages/core/src/getPeerDependencyIssues.ts b/packages/core/src/getPeerDependencyIssues.ts
index dc6ceaf299d..2fb95a9ad2e 100644
--- a/packages/core/src/getPeerDependencyIssues.ts
+++ b/packages/core/src/getPeerDependencyIssues.ts
@@ -8,6 +8,7 @@ import { DEFAULT_REGISTRIES } from '@pnpm/normalize-registries'
 
 export type ListMissingPeersOptions = Partial<GetContextOptions>
 & Pick<InstallOptions, 'hooks'
+| 'ignoreCompatibilityDb'
 | 'linkWorkspacePackagesDepth'
 | 'nodeVersion'
 | 'nodeLinker'
@@ -57,6 +58,7 @@ export async function getPeerDependencyIssues (
       forceFullResolution: true,
       hooks: {
         readPackage: createReadPackageHook({
+          ignoreCompatibilityDb: opts.ignoreCompatibilityDb,
           lockfileDir,
           overrides: opts.overrides,
           packageExtensions: opts.packageExtensions,
diff --git a/packages/core/src/install/extendInstallOptions.ts b/packages/core/src/install/extendInstallOptions.ts
index 2d4e99fb994..db5137e4172 100644
--- a/packages/core/src/install/extendInstallOptions.ts
+++ b/packages/core/src/install/extendInstallOptions.ts
@@ -32,6 +32,7 @@ export interface StrictInstallOptions {
   linkWorkspacePackagesDepth: number
   lockfileOnly: boolean
   fixLockfile: boolean
+  ignoreCompatibilityDb: boolean
   ignorePackageManifest: boolean
   preferFrozenLockfile: boolean
   saveWorkspaceProtocol: boolean | 'rolling'
@@ -147,6 +148,7 @@ const defaults = async (opts: InstallOptions) => {
     nodeLinker: 'isolated',
     overrides: {},
     ownLifecycleHooksStdio: 'inherit',
+    ignoreCompatibilityDb: false,
     ignorePackageManifest: false,
     packageExtensions: {},
     packageManager,
diff --git a/packages/core/src/install/index.ts b/packages/core/src/install/index.ts
index 461e13ceea3..5b6d5ceffb7 100644
--- a/packages/core/src/install/index.ts
+++ b/packages/core/src/install/index.ts
@@ -177,6 +177,7 @@ export async function mutateModules (
     // so reading its manifest explicitly here.
     await safeReadProjectManifestOnly(opts.lockfileDir)
   opts.hooks.readPackage = createReadPackageHook({
+    ignoreCompatibilityDb: opts.ignoreCompatibilityDb,
     readPackageHook: opts.hooks.readPackage,
     overrides: opts.overrides,
     lockfileDir: opts.lockfileDir,
@@ -546,12 +547,14 @@ export function createObjectChecksum (obj: Object) {
 
 export function createReadPackageHook (
   {
+    ignoreCompatibilityDb,
     lockfileDir,
     overrides,
     packageExtensions,
     peerDependencyRules,
     readPackageHook,
   }: {
+    ignoreCompatibilityDb?: boolean
     lockfileDir: string
     overrides?: Record<string, string>
     packageExtensions?: Record<string, PackageExtension>
@@ -563,7 +566,9 @@ export function createReadPackageHook (
   if (!isEmpty(overrides ?? {})) {
     hooks.push(createVersionsOverrider(overrides!, lockfileDir))
   }
-  hooks.push(createPackageExtender(fromPairs(compatPackageExtensions)))
+  if (!ignoreCompatibilityDb) {
+    hooks.push(createPackageExtender(fromPairs(compatPackageExtensions)))
+  }
   if (!isEmpty(packageExtensions ?? {})) {
     hooks.push(createPackageExtender(packageExtensions!))
   }
diff --git a/packages/core/test/install/packageExtensions.ts b/packages/core/test/install/packageExtensions.ts
index 31a1b2cde70..58fa17a6d0d 100644
--- a/packages/core/test/install/packageExtensions.ts
+++ b/packages/core/test/install/packageExtensions.ts
@@ -114,3 +114,18 @@ test('manifests are patched by extensions from the compatibility database', asyn
   const lockfile = await project.readLockfile()
   expect(lockfile.packages['/debug/4.0.0'].peerDependenciesMeta?.['supports-color']?.optional).toBe(true)
 })
+
+test('manifests are not patched by extensions from the compatibility database when ignoreCompatibilityDb is true', async () => {
+  const project = prepareEmpty()
+
+  await addDependenciesToPackage(
+    {},
+    ['debug@4.0.0'],
+    await testDefaults({
+      ignoreCompatibilityDb: true,
+    })
+  )
+
+  const lockfile = await project.readLockfile()
+  expect(lockfile.packages['/debug/4.0.0'].peerDependenciesMeta).toBeUndefined()
+})