diff --git a/src/packages/client/fixtures/scalarList/.gitignore b/src/packages/client/fixtures/scalarList/.gitignore
new file mode 100644
index 000000000000..f8aa4ebdb381
--- /dev/null
+++ b/src/packages/client/fixtures/scalarList/.gitignore
@@ -0,0 +1,3 @@
+@prisma
+migrations
+db
\ No newline at end of file
diff --git a/src/packages/client/fixtures/scalarList/main.ts b/src/packages/client/fixtures/scalarList/main.ts
new file mode 100644
index 000000000000..94dbe1e09c4f
--- /dev/null
+++ b/src/packages/client/fixtures/scalarList/main.ts
@@ -0,0 +1,23 @@
+import { PrismaClient } from './@prisma/client'
+
+async function main() {
+  const prisma = new PrismaClient()
+
+  await prisma.user.create({
+    data: {
+      hobbies: {
+        set: [
+          'sample 1 string',
+          '7fb1aef9-5250-4cf6-92c7-b01f53862822',
+          'sample 3 string',
+          '575e0b28-81fa-43e0-8f05-708a98d55c14',
+          'sample 5 string',
+        ],
+      },
+      name: 'name',
+    },
+  })
+  prisma.disconnect()
+}
+
+main().catch(console.error)
diff --git a/src/packages/client/fixtures/scalarList/prisma/schema.prisma b/src/packages/client/fixtures/scalarList/prisma/schema.prisma
new file mode 100644
index 000000000000..6d81bd582d81
--- /dev/null
+++ b/src/packages/client/fixtures/scalarList/prisma/schema.prisma
@@ -0,0 +1,10 @@
+datasource my_db {
+  provider = "postgres"
+  url      = env("POSTGRES_URL")
+}
+
+model User {
+  id      String   @default(cuid()) @id
+  name    String
+  hobbies String[]
+}
diff --git a/src/packages/client/fixtures/scalarList/tsconfig.json b/src/packages/client/fixtures/scalarList/tsconfig.json
new file mode 100644
index 000000000000..dd45bc25d5d7
--- /dev/null
+++ b/src/packages/client/fixtures/scalarList/tsconfig.json
@@ -0,0 +1,10 @@
+{
+  "compilerOptions": {
+    "strict": true,
+    "target": "es2018",
+    "module": "commonjs",
+    "esModuleInterop": true,
+    "noImplicitAny": false,
+    "lib": ["esnext"]
+  }
+}
diff --git a/src/packages/client/src/__tests__/uuid.test.ts b/src/packages/client/src/__tests__/uuid.test.ts
new file mode 100644
index 000000000000..0c3ace4b1edf
--- /dev/null
+++ b/src/packages/client/src/__tests__/uuid.test.ts
@@ -0,0 +1,66 @@
+import { DMMFClass, makeDocument } from '../runtime'
+import { getDMMF } from '../generation/getDMMF'
+
+const datamodel = `datasource my_db {
+  provider = "postgres"
+  url      = env("POSTGRES_URL")
+}
+
+model User {
+  id      String   @default(cuid()) @id
+  name    String
+  hobbies String[]
+}
+`
+
+describe('at least one validation', () => {
+  let dmmf
+  beforeAll(async () => {
+    dmmf = new DMMFClass(await getDMMF({ datamodel }))
+  })
+  test('string first', () => {
+    const select = {
+      data: {
+        hobbies: {
+          set: [
+            'sample 1 string',
+            '7fb1aef9-5250-4cf6-92c7-b01f53862822',
+            'sample 3 string',
+            '575e0b28-81fa-43e0-8f05-708a98d55c14',
+            'sample 5 string',
+          ],
+        },
+        name: 'name',
+      },
+    }
+    const document = makeDocument({
+      dmmf,
+      select,
+      rootTypeName: 'mutation',
+      rootField: 'createOneUser',
+    })
+    expect(() => document.validate(select, false)).not.toThrow()
+  })
+  test('uuid first', () => {
+    const select = {
+      data: {
+        hobbies: {
+          set: [
+            '7fb1aef9-5250-4cf6-92c7-b01f53862822',
+            'sample 3 string',
+            '575e0b28-81fa-43e0-8f05-708a98d55c14',
+            'sample 5 string',
+          ],
+        },
+        name: 'name',
+      },
+    }
+    const document = makeDocument({
+      dmmf,
+      select,
+      rootTypeName: 'mutation',
+      rootField: 'createOneUser',
+    })
+    expect(() => document.validate(select, false)).not.toThrow()
+  })
+})
diff --git a/src/packages/client/src/runtime/query.ts b/src/packages/client/src/runtime/query.ts
index 1c5e23862120..0f48d4f8ca84 100644
--- a/src/packages/client/src/runtime/query.ts
+++ b/src/packages/client/src/runtime/query.ts
@@ -1310,6 +1310,13 @@ function hasCorrectScalarType(
   if (graphQLType === 'List<String>' && expectedType === 'List<ID>') {
     return true
   }
+  if (
+    expectedType === 'List<String>' &&
+    (graphQLType === 'List<String | UUID>' ||
+      graphQLType === 'List<UUID | String>')
+  ) {
+    return true
+  }
 
   // Int is a subset of Float
   if (graphQLType === 'Int' && expectedType === 'Float') {