diff --git a/src/google/protobuf/port_def.inc b/src/google/protobuf/port_def.inc
index 4f73ff99f4a5..ad1cec3304d2 100644
--- a/src/google/protobuf/port_def.inc
+++ b/src/google/protobuf/port_def.inc
@@ -568,7 +568,7 @@
 // https://github.com/protocolbuffers/protobuf/issues/8310
 // Does not work yet with Visual Studio 2019 Update 16.10
 #define PROTOBUF_CONSTINIT constinit
-#elif __has_cpp_attribute(clang::require_constant_initialization)
+#elif !defined(_MSC_VER) && __has_cpp_attribute(clang::require_constant_initialization)
 #define PROTOBUF_CONSTINIT [[clang::require_constant_initialization]]
 #else
 #define PROTOBUF_CONSTINIT