diff --git a/cmake/CMakeLists.txt b/cmake/CMakeLists.txt
index 61a5c3dededf..b3caca90606a 100644
--- a/cmake/CMakeLists.txt
+++ b/cmake/CMakeLists.txt
@@ -176,20 +176,24 @@ if (protobuf_BUILD_SHARED_LIBS)
   set(protobuf_SHARED_OR_STATIC "SHARED")
 else (protobuf_BUILD_SHARED_LIBS)
   set(protobuf_SHARED_OR_STATIC "STATIC")
-  # In case we are building static libraries, link also the runtime library statically
-  # so that MSVCR*.DLL is not required at runtime.
-  # https://msdn.microsoft.com/en-us/library/2kzt1wy3.aspx
-  # This is achieved by replacing msvc option /MD with /MT and /MDd with /MTd
-  # http://www.cmake.org/Wiki/CMake_FAQ#How_can_I_build_my_MSVC_application_with_a_static_runtime.3F
-  if (MSVC AND protobuf_MSVC_STATIC_RUNTIME)
-    foreach(flag_var
-        CMAKE_CXX_FLAGS CMAKE_CXX_FLAGS_DEBUG CMAKE_CXX_FLAGS_RELEASE
-        CMAKE_CXX_FLAGS_MINSIZEREL CMAKE_CXX_FLAGS_RELWITHDEBINFO)
-      if(${flag_var} MATCHES "/MD")
-        string(REGEX REPLACE "/MD" "/MT" ${flag_var} "${${flag_var}}")
-      endif(${flag_var} MATCHES "/MD")
-    endforeach(flag_var)
-  endif (MSVC AND protobuf_MSVC_STATIC_RUNTIME)
+  if(CMAKE_VERSION VERSION_GREATER_EQUAL 3.15)
+    set(CMAKE_MSVC_RUNTIME_LIBRARY MultiThreaded$<$<CONFIG:Debug>:Debug>)
+  else()
+    # In case we are building static libraries, link also the runtime library statically
+    # so that MSVCR*.DLL is not required at runtime.
+    # https://msdn.microsoft.com/en-us/library/2kzt1wy3.aspx
+    # This is achieved by replacing msvc option /MD with /MT and /MDd with /MTd
+    # http://www.cmake.org/Wiki/CMake_FAQ#How_can_I_build_my_MSVC_application_with_a_static_runtime.3F
+    if (MSVC AND protobuf_MSVC_STATIC_RUNTIME)
+      foreach(flag_var
+          CMAKE_CXX_FLAGS CMAKE_CXX_FLAGS_DEBUG CMAKE_CXX_FLAGS_RELEASE
+          CMAKE_CXX_FLAGS_MINSIZEREL CMAKE_CXX_FLAGS_RELWITHDEBINFO)
+        if(${flag_var} MATCHES "/MD")
+          string(REGEX REPLACE "/MD" "/MT" ${flag_var} "${${flag_var}}")
+        endif(${flag_var} MATCHES "/MD")
+      endforeach(flag_var)
+    endif (MSVC AND protobuf_MSVC_STATIC_RUNTIME)
+  endif()
 endif (protobuf_BUILD_SHARED_LIBS)
 
 if (MSVC)