diff --git a/Tests/images/xmp_tags_orientation_exiftool.png b/Tests/images/xmp_tags_orientation_exiftool.png
new file mode 100644
index 00000000000..10f0f44009a
Binary files /dev/null and b/Tests/images/xmp_tags_orientation_exiftool.png differ
diff --git a/Tests/test_imageops.py b/Tests/test_imageops.py
index 87fffa7b724..01e40e6d4d5 100644
--- a/Tests/test_imageops.py
+++ b/Tests/test_imageops.py
@@ -345,11 +345,15 @@ def check(orientation_im):
                     check(orientation_im)
 
     # Orientation from "XML:com.adobe.xmp" info key
-    with Image.open("Tests/images/xmp_tags_orientation.png") as im:
-        assert im.getexif()[0x0112] == 3
+    for suffix in ("", "_exiftool"):
+        with Image.open("Tests/images/xmp_tags_orientation" + suffix + ".png") as im:
+            assert im.getexif()[0x0112] == 3
 
-        transposed_im = ImageOps.exif_transpose(im)
-        assert 0x0112 not in transposed_im.getexif()
+            transposed_im = ImageOps.exif_transpose(im)
+            assert 0x0112 not in transposed_im.getexif()
+
+            transposed_im._reload_exif()
+            assert 0x0112 not in transposed_im.getexif()
 
     # Orientation from "Raw profile type exif" info key
     # This test image has been manually hexedited from exif_imagemagick.png
diff --git a/src/PIL/Image.py b/src/PIL/Image.py
index 6abb1249166..4eb2dead655 100644
--- a/src/PIL/Image.py
+++ b/src/PIL/Image.py
@@ -1404,9 +1404,9 @@ def getexif(self):
         if 0x0112 not in self._exif:
             xmp_tags = self.info.get("XML:com.adobe.xmp")
             if xmp_tags:
-                match = re.search(r'tiff:Orientation="([0-9])"', xmp_tags)
+                match = re.search(r'tiff:Orientation(="|>)([0-9])', xmp_tags)
                 if match:
-                    self._exif[0x0112] = int(match[1])
+                    self._exif[0x0112] = int(match[2])
 
         return self._exif
 
diff --git a/src/PIL/ImageOps.py b/src/PIL/ImageOps.py
index f0d4545badf..48b41d87fda 100644
--- a/src/PIL/ImageOps.py
+++ b/src/PIL/ImageOps.py
@@ -601,10 +601,12 @@ def exif_transpose(image):
                     "Raw profile type exif"
                 ] = transposed_exif.tobytes().hex()
             elif "XML:com.adobe.xmp" in transposed_image.info:
-                transposed_image.info["XML:com.adobe.xmp"] = re.sub(
+                for pattern in (
                     r'tiff:Orientation="([0-9])"',
-                    "",
-                    transposed_image.info["XML:com.adobe.xmp"],
-                )
+                    r"<tiff:Orientation>([0-9])</tiff:Orientation>",
+                ):
+                    transposed_image.info["XML:com.adobe.xmp"] = re.sub(
+                        pattern, "", transposed_image.info["XML:com.adobe.xmp"]
+                    )
         return transposed_image
     return image.copy()