diff --git a/docs/source/inclusions/application_run_tip.rst b/docs/source/inclusions/application_run_tip.rst
new file mode 100644
index 00000000000..f6b1261b26d
--- /dev/null
+++ b/docs/source/inclusions/application_run_tip.rst
@@ -0,0 +1,7 @@
+.. tip::
+    When combining ``python-telegram-bot`` with other :mod:`asyncio` based frameworks, using this
+    method is likely not the best choice, as it blocks the event loop until it receives a stop
+    signal as described above.
+    Instead, you can manually call the methods listed below to start and shut down the application
+    and the :attr:`~telegram.ext.Application.updater`.
+    Keeping the event loop running and listening for a stop signal is then up to you.
\ No newline at end of file
diff --git a/telegram/ext/_application.py b/telegram/ext/_application.py
index 233d78fe23c..eab0bc90212 100644
--- a/telegram/ext/_application.py
+++ b/telegram/ext/_application.py
@@ -592,9 +592,12 @@ def run_polling(
         If :attr:`post_shutdown` is set, it will be called after both :meth:`shutdown`
         and :meth:`telegram.ext.Updater.shutdown`.
 
+        .. include:: inclusions/application_run_tip.rst
+
         .. seealso::
             :meth:`initialize`, :meth:`start`, :meth:`stop`, :meth:`shutdown`
-            :meth:`telegram.ext.Updater.start_polling`, :meth:`run_webhook`
+            :meth:`telegram.ext.Updater.start_polling`, :meth:`telegram.ext.Updater.stop`,
+            :meth:`run_webhook`
 
         Args:
             poll_interval (:obj:`float`, optional): Time to wait between polling updates from
@@ -705,9 +708,12 @@ def run_webhook(
         If :attr:`post_shutdown` is set, it will be called after both :meth:`shutdown`
         and :meth:`telegram.ext.Updater.shutdown`.
 
+        .. include:: inclusions/application_run_tip.rst
+
         .. seealso::
             :meth:`initialize`, :meth:`start`, :meth:`stop`, :meth:`shutdown`
-            :meth:`telegram.ext.Updater.start_webhook`, :meth:`run_polling`
+            :meth:`telegram.ext.Updater.start_webhook`, :meth:`telegram.ext.Updater.stop`,
+            :meth:`run_polling`
 
         Args:
             listen (:obj:`str`, optional): IP-Address to listen on. Defaults to