diff --git a/lib/modules/manager/pip-compile/extract.spec.ts b/lib/modules/manager/pip-compile/extract.spec.ts
index 533348a7571c8f..8a05a895f36942 100644
--- a/lib/modules/manager/pip-compile/extract.spec.ts
+++ b/lib/modules/manager/pip-compile/extract.spec.ts
@@ -366,6 +366,29 @@ describe('modules/manager/pip-compile/extract', () => {
     );
   });
 
+  it('adds transitive dependency to deps in package file', async () => {
+    fs.readLocalFile.mockResolvedValueOnce(
+      getSimpleRequirementsFile(
+        'pip-compile --output-file=requirements.txt requirements.in',
+        ['friendly-bard==1.0.1', 'bards-friend==1.0.0'],
+      ),
+    );
+    fs.readLocalFile.mockResolvedValueOnce('FrIeNdLy-._.-bArD>=1.0.0');
+
+    const lockFiles = ['requirements.txt'];
+    const packageFiles = await extractAllPackageFiles({}, lockFiles);
+    expect(packageFiles).toBeDefined();
+    const packageFile = packageFiles!.pop();
+    expect(packageFile!.deps).toHaveLength(2);
+    expect(packageFile!.deps[1]).toEqual({
+      datasource: 'pypi',
+      depType: 'indirect',
+      depName: 'bards-friend',
+      lockedVersion: '1.0.0',
+      enabled: false,
+    });
+  });
+
   it('handles -r reference to another input file', async () => {
     fs.readLocalFile.mockImplementation((name): any => {
       if (name === '1.in') {
diff --git a/lib/modules/manager/pip-compile/extract.ts b/lib/modules/manager/pip-compile/extract.ts
index b3b8730c24f788..dd746f7139a8ca 100644
--- a/lib/modules/manager/pip-compile/extract.ts
+++ b/lib/modules/manager/pip-compile/extract.ts
@@ -5,7 +5,12 @@ import { ensureLocalPath } from '../../../util/fs/util';
 import { normalizeDepName } from '../../datasource/pypi/common';
 import { extractPackageFile as extractRequirementsFile } from '../pip_requirements/extract';
 import { extractPackageFile as extractSetupPyFile } from '../pip_setup';
-import type { ExtractConfig, PackageFile, PackageFileContent } from '../types';
+import type {
+  ExtractConfig,
+  PackageDependency,
+  PackageFile,
+  PackageFileContent,
+} from '../types';
 import { extractHeaderCommand } from './common';
 import type {
   DependencyBetweenFiles,
@@ -135,6 +140,7 @@ export async function extractAllPackageFiles(
         );
         const existingPackageFile = packageFiles.get(packageFile)!;
         existingPackageFile.lockFiles!.push(fileMatch);
+        extendWithIndirectDeps(existingPackageFile, lockedDeps);
         lockFileSources.set(fileMatch, existingPackageFile);
         continue;
       }
@@ -183,6 +189,7 @@ export async function extractAllPackageFiles(
             );
           }
         }
+        extendWithIndirectDeps(packageFileContent, lockedDeps);
         const newPackageFile: PackageFile = {
           ...packageFileContent,
           lockFiles: [fileMatch],
@@ -230,3 +237,47 @@ export async function extractAllPackageFiles(
   );
   return result;
 }
+
+function extendWithIndirectDeps(
+  packageFileContent: PackageFileContent,
+  lockedDeps: PackageDependency[],
+): void {
+  for (const lockedDep of lockedDeps) {
+    if (
+      !packageFileContent.deps.find(
+        (dep) =>
+          normalizeDepName(lockedDep.depName!) ===
+          normalizeDepName(dep.depName!),
+      )
+    ) {
+      packageFileContent.deps.push(indirectDep(lockedDep));
+    }
+  }
+}
+
+/**
+ * As indirect dependecies don't exist in the package file, we need to
+ * create them from the lock file.
+ *
+ * By removing currentValue and currentVersion, we ensure that they
+ * are handled like unconstrained dependencies with locked version.
+ * Such packages are updated when their update strategy
+ * is set to 'update-lockfile',
+ * see: lib/workers/repository/process/lookup/index.ts.
+ *
+ * By disabling them by default, we won't create noise by updating them.
+ * Unless they have vulnerability alert, then they are forced to be updated.
+ * @param dep dependency extracted from lock file (requirements.txt)
+ * @returns unconstrained dependency with locked version
+ */
+function indirectDep(dep: PackageDependency): PackageDependency {
+  const result = {
+    ...dep,
+    lockedVersion: dep.currentVersion,
+    depType: 'indirect',
+    enabled: false,
+  };
+  delete result.currentValue;
+  delete result.currentVersion;
+  return result;
+}
diff --git a/lib/modules/manager/pip-compile/readme.md b/lib/modules/manager/pip-compile/readme.md
index d7ca06f5477daa..24324ec67403cc 100644
--- a/lib/modules/manager/pip-compile/readme.md
+++ b/lib/modules/manager/pip-compile/readme.md
@@ -83,3 +83,9 @@ Renovate reads the `requirements.txt` file and extracts these `pip-compile` argu
 - `--output-file`
 
 All other allowed `pip-compile` arguments will be passed over without modification.
+
+### Transitive / indirect dependencies
+
+This manager detects dependencies that only appear in lock files.
+They are disabled by default but can be forced to enable by vulnerability alerts.
+They will be upgraded with `--upgrade-package` option.