diff --git a/src/ast/NodeInteractions.ts b/src/ast/NodeInteractions.ts
index e73af1a122e..35113cb5b0f 100644
--- a/src/ast/NodeInteractions.ts
+++ b/src/ast/NodeInteractions.ts
@@ -1,7 +1,6 @@
 import SpreadElement from './nodes/SpreadElement';
 import { ExpressionEntity, UNKNOWN_EXPRESSION } from './nodes/shared/Expression';
 
-// TODO Lukas for usages and see if caching makes sense
 export const INTERACTION_ACCESSED = 0;
 export const INTERACTION_ASSIGNED = 1;
 export const INTERACTION_CALLED = 2;
@@ -11,7 +10,7 @@ export interface NodeInteractionAccessed {
 	type: typeof INTERACTION_ACCESSED;
 }
 
-export const NODE_INTERACTION_ACCESS: NodeInteractionAccessed = {
+export const NODE_INTERACTION_UNKNOWN_ACCESS: NodeInteractionAccessed = {
 	thisArg: null,
 	type: INTERACTION_ACCESSED
 };
@@ -39,6 +38,16 @@ export interface NodeInteractionCalled {
 
 export const NO_ARGS = [];
 
+// While this is technically a call without arguments, we can compare against
+// this reference in places where precise values or thisArg would make a
+// difference
+export const NODE_INTERACTION_UNKNOWN_CALL: NodeInteractionCalled = {
+	args: NO_ARGS,
+	thisArg: null,
+	type: INTERACTION_CALLED,
+	withNew: false
+};
+
 export type NodeInteraction =
 	| NodeInteractionAccessed
 	| NodeInteractionAssigned
diff --git a/src/ast/nodes/Identifier.ts b/src/ast/nodes/Identifier.ts
index 73bb9f90f59..b4ddde25c0f 100644
--- a/src/ast/nodes/Identifier.ts
+++ b/src/ast/nodes/Identifier.ts
@@ -10,7 +10,7 @@ import {
 	INTERACTION_ACCESSED,
 	INTERACTION_ASSIGNED,
 	INTERACTION_CALLED,
-	NODE_INTERACTION_ACCESS,
+	NODE_INTERACTION_UNKNOWN_ACCESS,
 	NodeInteraction,
 	NodeInteractionCalled
 } from '../NodeInteractions';
@@ -140,7 +140,11 @@ export default class Identifier extends NodeBase implements PatternNode {
 		return (
 			(this.context.options.treeshake as NormalizedTreeshakingOptions).unknownGlobalSideEffects &&
 			this.variable instanceof GlobalVariable &&
-			this.variable.hasEffectsOnInteractionAtPath(EMPTY_PATH, NODE_INTERACTION_ACCESS, context)
+			this.variable.hasEffectsOnInteractionAtPath(
+				EMPTY_PATH,
+				NODE_INTERACTION_UNKNOWN_ACCESS,
+				context
+			)
 		);
 	}
 
diff --git a/src/ast/nodes/SpreadElement.ts b/src/ast/nodes/SpreadElement.ts
index 0a9c4f31505..4a863c1b785 100644
--- a/src/ast/nodes/SpreadElement.ts
+++ b/src/ast/nodes/SpreadElement.ts
@@ -1,7 +1,7 @@
 import type { NormalizedTreeshakingOptions } from '../../rollup/types';
 import type { HasEffectsContext } from '../ExecutionContext';
 import type { NodeInteractionWithThisArg } from '../NodeInteractions';
-import { NODE_INTERACTION_ACCESS } from '../NodeInteractions';
+import { NODE_INTERACTION_UNKNOWN_ACCESS } from '../NodeInteractions';
 import { type ObjectPath, type PathTracker, UNKNOWN_PATH, UnknownKey } from '../utils/PathTracker';
 import type * as NodeType from './NodeType';
 import { type ExpressionNode, NodeBase } from './shared/Node';
@@ -34,7 +34,7 @@ export default class SpreadElement extends NodeBase {
 				(propertyReadSideEffects === 'always' ||
 					this.argument.hasEffectsOnInteractionAtPath(
 						UNKNOWN_PATH,
-						NODE_INTERACTION_ACCESS,
+						NODE_INTERACTION_UNKNOWN_ACCESS,
 						context
 					)))
 		);
diff --git a/src/ast/nodes/shared/FunctionBase.ts b/src/ast/nodes/shared/FunctionBase.ts
index 6bd2c4d0152..a1517cb7e08 100644
--- a/src/ast/nodes/shared/FunctionBase.ts
+++ b/src/ast/nodes/shared/FunctionBase.ts
@@ -6,9 +6,9 @@ import {
 	type InclusionContext
 } from '../../ExecutionContext';
 import {
-	INTERACTION_ACCESSED,
 	INTERACTION_CALLED,
-	NO_ARGS,
+	NODE_INTERACTION_UNKNOWN_ACCESS,
+	NODE_INTERACTION_UNKNOWN_CALL,
 	NodeInteraction,
 	NodeInteractionCalled,
 	NodeInteractionWithThisArg
@@ -105,14 +105,14 @@ export default abstract class FunctionBase extends NodeBase {
 			if (
 				returnExpression.hasEffectsOnInteractionAtPath(
 					['then'],
-					{ args: NO_ARGS, thisArg: returnExpression, type: INTERACTION_CALLED, withNew: false },
+					NODE_INTERACTION_UNKNOWN_CALL,
 					context
 				) ||
 				(propertyReadSideEffects &&
 					(propertyReadSideEffects === 'always' ||
 						returnExpression.hasEffectsOnInteractionAtPath(
 							['then'],
-							{ thisArg: returnExpression, type: INTERACTION_ACCESSED },
+							NODE_INTERACTION_UNKNOWN_ACCESS,
 							context
 						)))
 			) {
diff --git a/src/ast/nodes/shared/MethodBase.ts b/src/ast/nodes/shared/MethodBase.ts
index a8bdb505166..fd76f898643 100644
--- a/src/ast/nodes/shared/MethodBase.ts
+++ b/src/ast/nodes/shared/MethodBase.ts
@@ -5,6 +5,7 @@ import {
 	INTERACTION_ASSIGNED,
 	INTERACTION_CALLED,
 	NO_ARGS,
+	NODE_INTERACTION_UNKNOWN_CALL,
 	NodeInteraction,
 	NodeInteractionCalled,
 	NodeInteractionWithThisArg
@@ -139,7 +140,7 @@ export default class MethodBase extends NodeBase implements DeoptimizableEntity
 				this.accessedValue = UNKNOWN_EXPRESSION;
 				return (this.accessedValue = this.value.getReturnExpressionWhenCalledAtPath(
 					EMPTY_PATH,
-					{ args: NO_ARGS, thisArg: null, type: INTERACTION_CALLED, withNew: false },
+					NODE_INTERACTION_UNKNOWN_CALL,
 					SHARED_RECURSION_TRACKER,
 					this
 				));
diff --git a/src/ast/nodes/shared/MethodTypes.ts b/src/ast/nodes/shared/MethodTypes.ts
index bebc12f7376..993ebbc91c1 100644
--- a/src/ast/nodes/shared/MethodTypes.ts
+++ b/src/ast/nodes/shared/MethodTypes.ts
@@ -2,8 +2,8 @@ import type { HasEffectsContext } from '../../ExecutionContext';
 import {
 	INTERACTION_ACCESSED,
 	INTERACTION_CALLED,
-	NO_ARGS,
 	NODE_INTERACTION_UNKNOWN_ASSIGNMENT,
+	NODE_INTERACTION_UNKNOWN_CALL,
 	NodeInteraction,
 	NodeInteractionCalled,
 	NodeInteractionWithThisArg
@@ -84,12 +84,7 @@ export class Method extends ExpressionEntity {
 					if (
 						interaction.args[argIndex]?.hasEffectsOnInteractionAtPath(
 							EMPTY_PATH,
-							{
-								args: NO_ARGS,
-								thisArg: null,
-								type: INTERACTION_CALLED,
-								withNew: false
-							},
+							NODE_INTERACTION_UNKNOWN_CALL,
 							context
 						)
 					) {
diff --git a/src/ast/values.ts b/src/ast/values.ts
index c5e22d1aecc..c180143921c 100644
--- a/src/ast/values.ts
+++ b/src/ast/values.ts
@@ -2,7 +2,7 @@ import type { HasEffectsContext } from './ExecutionContext';
 import {
 	INTERACTION_ACCESSED,
 	INTERACTION_CALLED,
-	NO_ARGS,
+	NODE_INTERACTION_UNKNOWN_CALL,
 	NodeInteraction,
 	NodeInteractionCalled
 } from './NodeInteractions';
@@ -153,16 +153,7 @@ const stringReplace: RawMemberDescription = {
 				(typeof arg1.getLiteralValueAtPath(EMPTY_PATH, SHARED_RECURSION_TRACKER, {
 					deoptimizeCache() {}
 				}) === 'symbol' &&
-					arg1.hasEffectsOnInteractionAtPath(
-						EMPTY_PATH,
-						{
-							args: NO_ARGS,
-							thisArg: null,
-							type: INTERACTION_CALLED,
-							withNew: false
-						},
-						context
-					))
+					arg1.hasEffectsOnInteractionAtPath(EMPTY_PATH, NODE_INTERACTION_UNKNOWN_CALL, context))
 			);
 		},
 		returns: UNKNOWN_LITERAL_STRING