diff --git a/serde/build.rs b/serde/build.rs
index 2d985b1c4..e36ed62f5 100644
--- a/serde/build.rs
+++ b/serde/build.rs
@@ -69,11 +69,12 @@ fn main() {
         println!("cargo:rustc-cfg=num_nonzero");
     }
 
-    // TryFrom and Atomic types stabilized in Rust 1.34:
+    // TryFrom, Atomic types, and non-zero signed integers stabilized in Rust 1.34:
     // https://blog.rust-lang.org/2019/04/11/Rust-1.34.0.html#tryfrom-and-tryinto
     // https://blog.rust-lang.org/2019/04/11/Rust-1.34.0.html#library-stabilizations
     if minor >= 34 {
         println!("cargo:rustc-cfg=core_try_from");
+        println!("cargo:rustc-cfg=num_nonzero_signed");
 
         // Whitelist of archs that support std::sync::atomic module. Ideally we
         // would use #[cfg(target_has_atomic = "...")] but it is not stable yet.
diff --git a/serde/src/de/impls.rs b/serde/src/de/impls.rs
index 9e72aad23..e96314809 100644
--- a/serde/src/de/impls.rs
+++ b/serde/src/de/impls.rs
@@ -2404,7 +2404,6 @@ macro_rules! nonzero_integers {
 }
 
 nonzero_integers! {
-    // Not including signed NonZeroI* since they might be removed
     NonZeroU8,
     NonZeroU16,
     NonZeroU32,
@@ -2412,12 +2411,26 @@ nonzero_integers! {
     NonZeroUsize,
 }
 
+#[cfg(num_nonzero_signed)]
+nonzero_integers! {
+    NonZeroI8,
+    NonZeroI16,
+    NonZeroI32,
+    NonZeroI64,
+    NonZeroIsize,
+}
+
 // Currently 128-bit integers do not work on Emscripten targets so we need an
 // additional `#[cfg]`
 serde_if_integer128! {
     nonzero_integers! {
         NonZeroU128,
     }
+
+    #[cfg(num_nonzero_signed)]
+    nonzero_integers! {
+        NonZeroI128,
+    }
 }
 
 ////////////////////////////////////////////////////////////////////////////////
diff --git a/serde/src/ser/impls.rs b/serde/src/ser/impls.rs
index caf48e89d..0ac667dbf 100644
--- a/serde/src/ser/impls.rs
+++ b/serde/src/ser/impls.rs
@@ -481,7 +481,6 @@ macro_rules! nonzero_integers {
 }
 
 nonzero_integers! {
-    // Not including signed NonZeroI* since they might be removed
     NonZeroU8,
     NonZeroU16,
     NonZeroU32,
@@ -489,12 +488,26 @@ nonzero_integers! {
     NonZeroUsize,
 }
 
+#[cfg(num_nonzero_signed)]
+nonzero_integers! {
+    NonZeroI8,
+    NonZeroI16,
+    NonZeroI32,
+    NonZeroI64,
+    NonZeroIsize,
+}
+
 // Currently 128-bit integers do not work on Emscripten targets so we need an
 // additional `#[cfg]`
 serde_if_integer128! {
     nonzero_integers! {
         NonZeroU128,
     }
+
+    #[cfg(num_nonzero_signed)]
+    nonzero_integers! {
+        NonZeroI128,
+    }
 }
 
 impl<T> Serialize for Cell<T>