diff --git a/packages/instrumenter/package.json b/packages/instrumenter/package.json
index 8f78b814bc..beec10219f 100644
--- a/packages/instrumenter/package.json
+++ b/packages/instrumenter/package.json
@@ -39,7 +39,8 @@
     "@babel/preset-typescript": "~7.12.1 ",
     "@stryker-mutator/api": "4.3.1",
     "@stryker-mutator/util": "4.3.1",
-    "angular-html-parser": "~1.7.0"
+    "angular-html-parser": "~1.7.0",
+    "weapon-regex": "~0.3.0"
   },
   "devDependencies": {
     "@babel/preset-react": "~7.12.1",
diff --git a/packages/instrumenter/src/mutators/index.ts b/packages/instrumenter/src/mutators/index.ts
index f62a043848..85b9d5c0f5 100644
--- a/packages/instrumenter/src/mutators/index.ts
+++ b/packages/instrumenter/src/mutators/index.ts
@@ -17,6 +17,7 @@ import { ObjectLiteralMutator } from './object-literal-mutator';
 import { UnaryOperatorMutator } from './unary-operator-mutator';
 import { UpdateOperatorMutator } from './update-operator-mutator';
 import { MutatorOptions } from './mutator-options';
+import { RegexMutator } from './regex-mutator';
 
 export * from './node-mutator';
 export * from './mutator-options';
@@ -34,6 +35,7 @@ export const mutators: NodeMutator[] = [
   new StringLiteralMutator(),
   new UnaryOperatorMutator(),
   new UpdateOperatorMutator(),
+  new RegexMutator(),
 ];
 export const mutate = (node: NodePath, { excludedMutations }: MutatorOptions): NamedNodeMutation[] => {
   return flatMap(mutators, (mutator) =>
diff --git a/packages/instrumenter/src/mutators/regex-mutator.ts b/packages/instrumenter/src/mutators/regex-mutator.ts
new file mode 100644
index 0000000000..00f1fa5fae
--- /dev/null
+++ b/packages/instrumenter/src/mutators/regex-mutator.ts
@@ -0,0 +1,63 @@
+import * as types from '@babel/types';
+import { NodePath } from '@babel/core';
+import * as weaponRegex from 'weapon-regex';
+
+import { NodeMutation } from '../mutant';
+
+import { NodeMutator } from '.';
+
+/**
+ * Checks that a string literal is an obvious regex string literal
+ * @param path The string literal to checks
+ * @example
+ * new RegExp("\\d{4}");
+ */
+function isObviousRegexString(path: NodePath<types.StringLiteral>) {
+  return (
+    path.parentPath.isNewExpression() &&
+    types.isIdentifier(path.parentPath.node.callee) &&
+    path.parentPath.node.callee.name === RegExp.name &&
+    path.parentPath.node.arguments[0] === path.node
+  );
+}
+const weaponRegexOptions: weaponRegex.Options = { mutationLevels: [1] };
+
+function mutatePattern(pattern: string): string[] {
+  if (pattern.length) {
+    try {
+      return weaponRegex.mutate(pattern, weaponRegexOptions).map((mutant) => mutant.pattern);
+    } catch (err) {
+      console.error(
+        `[RegexMutator]: The Regex parser of weapon-regex couldn't parse this regex pattern: "${pattern}". Please report this issue at https://github.com/stryker-mutator/weapon-regex/issues. Inner error: ${err.message}`
+      );
+    }
+  }
+  return [];
+}
+
+export class RegexMutator implements NodeMutator {
+  public name = 'Regex';
+
+  public mutate(path: NodePath): NodeMutation[] {
+    if (path.isRegExpLiteral()) {
+      return mutatePattern(path.node.pattern).map((replacementPattern) => {
+        const replacement = types.cloneNode(path.node, false);
+        replacement.pattern = replacementPattern;
+        return {
+          original: path.node,
+          replacement,
+        };
+      });
+    } else if (path.isStringLiteral() && isObviousRegexString(path)) {
+      return mutatePattern(path.node.value).map((replacementPattern) => {
+        const replacement = types.cloneNode(path.node, false);
+        replacement.value = replacementPattern;
+        return {
+          original: path.node,
+          replacement,
+        };
+      });
+    }
+    return [];
+  }
+}
diff --git a/packages/instrumenter/src/tsconfig.json b/packages/instrumenter/src/tsconfig.json
index 4022aebfe2..cb9df01984 100644
--- a/packages/instrumenter/src/tsconfig.json
+++ b/packages/instrumenter/src/tsconfig.json
@@ -16,5 +16,6 @@
     {
       "path": "../../util/tsconfig.src.json"
     }
-  ]
+  ],
+  "include": ["**/*.*", "../typings/*.d.ts"]
 }
diff --git a/packages/instrumenter/src/typings/weapon-regex.ts b/packages/instrumenter/src/typings/weapon-regex.ts
new file mode 100644
index 0000000000..bfed53020a
--- /dev/null
+++ b/packages/instrumenter/src/typings/weapon-regex.ts
@@ -0,0 +1,12 @@
+declare module 'weapon-regex' {
+  export interface Options {
+    mutationLevels: number[];
+  }
+
+  export interface Mutant {
+    description: string;
+    pattern: string;
+  }
+
+  export function mutate(pattern: string, ops?: Options): Mutant[];
+}
diff --git a/packages/instrumenter/test/unit/mutators/regex-mutator.spec.ts b/packages/instrumenter/test/unit/mutators/regex-mutator.spec.ts
new file mode 100644
index 0000000000..231537ebad
--- /dev/null
+++ b/packages/instrumenter/test/unit/mutators/regex-mutator.spec.ts
@@ -0,0 +1,40 @@
+import { expect } from 'chai';
+import sinon from 'sinon';
+
+import { RegexMutator } from '../../../src/mutators/regex-mutator';
+import { expectJSMutation } from '../../helpers/expect-mutation';
+
+describe(RegexMutator.name, () => {
+  let sut: RegexMutator;
+  beforeEach(() => {
+    sut = new RegexMutator();
+  });
+
+  it('should have name "Regex"', () => {
+    expect(sut.name).eq('Regex');
+  });
+
+  it('should not mutate normal string literals', () => {
+    expectJSMutation(sut, '""');
+  });
+
+  it('should mutate a regex literal', () => {
+    expectJSMutation(sut, '/\\d{4}/', '/\\d/', '/\\D{4}/');
+  });
+
+  it("should not crash if a regex couldn't be parsed", () => {
+    const errorStub = sinon.stub(console, 'error');
+    expectJSMutation(sut, '/[[]]/');
+    expect(errorStub).calledWith(
+      '[RegexMutator]: The Regex parser of weapon-regex couldn\'t parse this regex pattern: "[[]]". Please report this issue at https://github.com/stryker-mutator/weapon-regex/issues. Inner error: [Error] Parser: Position 1:1, found "[[]]"'
+    );
+  });
+
+  it('should mutate obvious Regex string literals', () => {
+    expectJSMutation(sut, 'new RegExp("\\\\d{4}")', 'new RegExp("\\\\d")', 'new RegExp("\\\\D{4}")');
+  });
+
+  it('should not mutate the flags of a new RegExp constructor', () => {
+    expectJSMutation(sut, 'new RegExp("", "\\\\d{4}")');
+  });
+});