diff --git a/e2e/test/jest-with-ts/package.json b/e2e/test/jest-with-ts/package.json
index 7330158540..4487fc3949 100644
--- a/e2e/test/jest-with-ts/package.json
+++ b/e2e/test/jest-with-ts/package.json
@@ -3,7 +3,7 @@
   "description": "A test project for using stryker with jest and jest-ts preprocessor. Inspired by the stryker-dashboard source code.",
   "scripts": {
     "test": "stryker run",
-    "test:original": "jest",
+    "test:unit": "jest",
     "posttest": "mocha --require ../../tasks/ts-node-register.js verify/verify.ts"
   },
   "dependencies": {
diff --git a/e2e/test/jest-with-ts/src/components/hello-component.test.ts b/e2e/test/jest-with-ts/src/components/hello-component.test.ts
new file mode 100644
index 0000000000..dfad7661c0
--- /dev/null
+++ b/e2e/test/jest-with-ts/src/components/hello-component.test.ts
@@ -0,0 +1,15 @@
+/**
+ * @jest-environment jsdom
+ */
+
+import './hello-component';
+
+describe('hello-component', () => {
+
+  fit('should show a "hello world" message', () => {
+    const element = document.createElement('jest-hello');
+    document.body.appendChild(element);
+    expect(element.innerText).toEqual('hello world');
+    document.body.removeChild(element);
+  });
+});
diff --git a/e2e/test/jest-with-ts/src/components/hello-component.ts b/e2e/test/jest-with-ts/src/components/hello-component.ts
new file mode 100644
index 0000000000..cdb176a21a
--- /dev/null
+++ b/e2e/test/jest-with-ts/src/components/hello-component.ts
@@ -0,0 +1,7 @@
+
+export class HelloComponent extends HTMLElement {
+  connectedCallback() {
+    this.innerText = 'hello world';
+  }
+}
+window.customElements.define('jest-hello', HelloComponent);
diff --git a/e2e/test/jest-with-ts/stryker.conf.json b/e2e/test/jest-with-ts/stryker.conf.json
index e4b0c67d86..70b571e8c1 100644
--- a/e2e/test/jest-with-ts/stryker.conf.json
+++ b/e2e/test/jest-with-ts/stryker.conf.json
@@ -1,7 +1,8 @@
 {
   "$schema": "../../node_modules/@stryker-mutator/core/schema/stryker-schema.json",
   "mutate": [
-    "src/data-access/mappers/TableStorageMapper.ts"
+    "src/data-access/mappers/TableStorageMapper.ts",
+    "src/components/hello-component.ts"
   ],
   "packageManager": "npm",
   "testRunner": "jest",
diff --git a/e2e/test/jest-with-ts/tsconfig.json b/e2e/test/jest-with-ts/tsconfig.json
index a4596e57f1..2c22ec470f 100644
--- a/e2e/test/jest-with-ts/tsconfig.json
+++ b/e2e/test/jest-with-ts/tsconfig.json
@@ -4,7 +4,8 @@
     "esModuleInterop": true,
     "module": "commonjs",
     "lib": [
-      "es2017"
+      "es2017",
+      "DOM"
     ],
     "types": [
       "jest",
diff --git a/e2e/test/jest-with-ts/verify/verify.ts b/e2e/test/jest-with-ts/verify/verify.ts
index 2f9627c016..b25649a10e 100644
--- a/e2e/test/jest-with-ts/verify/verify.ts
+++ b/e2e/test/jest-with-ts/verify/verify.ts
@@ -5,8 +5,8 @@ describe('Verify stryker has ran correctly', () => {
   it('should report correct score', async () => {
     await expectMetrics({
       ignored: 0,
-      killed: 15,
-      mutationScore: 53.57,
+      killed: 17,
+      mutationScore: 56.67,
       noCoverage: 0,
       survived: 13,
       timeout: 0,
diff --git a/packages/instrumenter/src/disable-type-checks.ts b/packages/instrumenter/src/disable-type-checks.ts
index 91a7fbf5b7..ead68a00a8 100644
--- a/packages/instrumenter/src/disable-type-checks.ts
+++ b/packages/instrumenter/src/disable-type-checks.ts
@@ -7,6 +7,7 @@ import { AstFormat, HtmlAst, JSAst, TSAst } from './syntax';
 
 const commentDirectiveRegEx = /^(\s*)@(ts-[a-z-]+).*$/;
 const tsDirectiveLikeRegEx = /@(ts-[a-z-]+)/;
+const startingCommentRegex = /(^\s*\/\*.*?\*\/)/gs;
 
 export async function disableTypeChecks(file: File, options: ParserOptions) {
   if (isJSFileWithoutTSDirectives(file)) {
@@ -43,7 +44,9 @@ function prefixWithNoCheck(code: string): string {
       return code;
     }
   } else {
-    return `// @ts-nocheck\n${code}`;
+    // We should leave comments, like `/** @jest-env jsdom */ at the top of the file, see #2569
+    const commentMatch = startingCommentRegex.exec(code);
+    return `${commentMatch?.[1].concat('\n') ?? ''}// @ts-nocheck\n${code.substr(commentMatch?.[1].length ?? 0)}`;
   }
 }
 
diff --git a/packages/instrumenter/test/unit/disable-type-checks.spec.ts b/packages/instrumenter/test/unit/disable-type-checks.spec.ts
index 9396d1224a..3e3bda7713 100644
--- a/packages/instrumenter/test/unit/disable-type-checks.spec.ts
+++ b/packages/instrumenter/test/unit/disable-type-checks.spec.ts
@@ -27,6 +27,14 @@ describe(disableTypeChecks.name, () => {
       });
     });
 
+    describe('with jest directive (`@jest-environment`)', () => {
+      it('should insert `// @ts-nocheck` after the jest directive', async () => {
+        const inputFile = new File('foo.js', '/**\n* @jest-environment jsdom\n*/\nfoo.bar();');
+        const actual = await disableTypeChecks(inputFile, { plugins: null });
+        assertions.expectTextFileEqual(actual, new File('foo.js', '/**\n* @jest-environment jsdom\n*/\n// @ts-nocheck\n\nfoo.bar();'));
+      });
+    });
+
     it('should not even parse the file if "@ts-" can\'t be found anywhere in the file (performance optimization)', async () => {
       const createParserSpy = sinon.spy(parsers, 'createParser');
       const inputFile = new File('foo.js', 'foo.bar();');
@@ -47,7 +55,7 @@ describe(disableTypeChecks.name, () => {
     });
 
     it('should remove @ts directive from single line', async () => {
-      await arrangeActAssert('// @ts-check\nfoo.bar();', '// \nfoo.bar();');
+      await arrangeActAssert('baz();// @ts-check\nfoo.bar();', 'baz();// \nfoo.bar();');
     });
 
     it('should not remove @ts comments which occur later on the comment line (since then they are not considered a directive)', async () => {
@@ -55,7 +63,7 @@ describe(disableTypeChecks.name, () => {
     });
 
     it('should remove @ts directive from multiline', async () => {
-      await arrangeActAssert('/* @ts-expect-error */\nfoo.bar();', '/*  */\nfoo.bar();');
+      await arrangeActAssert('baz();/* @ts-expect-error */\nfoo.bar();', 'baz();/*  */\nfoo.bar();');
     });
 
     describe('with string', () => {