diff --git a/crates/swc_ecma_minifier/src/compress/optimize/iife.rs b/crates/swc_ecma_minifier/src/compress/optimize/iife.rs
index 8e14005626ba..220fe9225d49 100644
--- a/crates/swc_ecma_minifier/src/compress/optimize/iife.rs
+++ b/crates/swc_ecma_minifier/src/compress/optimize/iife.rs
@@ -200,6 +200,7 @@ where
 
                         if let Some(arg) = arg {
                             match &**arg {
+                                Expr::Lit(Lit::Regex(..)) => continue,
                                 Expr::Lit(Lit::Str(s)) if s.value.len() > 3 => continue,
                                 Expr::Lit(..) => {}
                                 _ => continue,
diff --git a/crates/swc_ecma_minifier/tests/exec.rs b/crates/swc_ecma_minifier/tests/exec.rs
index 33003e875041..b5b22be4404a 100644
--- a/crates/swc_ecma_minifier/tests/exec.rs
+++ b/crates/swc_ecma_minifier/tests/exec.rs
@@ -10327,3 +10327,34 @@ fn issue_6217_1() {
         false,
     );
 }
+
+#[test]
+fn issue_6279_1() {
+    run_default_exec_test(
+        r###"
+        function run(str, r) {
+            let m
+            while(m = r.exec(str)) {
+            console.log(m)
+            }
+        }
+        run('abcda', /a/g)
+        "###,
+    );
+}
+
+#[test]
+fn issue_6279_2() {
+    run_default_exec_test(
+        r###"
+        const r = new RegExp('a', 'g');
+        function run(str, r) {
+            let m
+            while (m = r.exec(str)) {
+                console.log(m)
+            }
+        }
+        run('abcda', r)
+        "###,
+    );
+}
diff --git a/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/input.js b/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/input.js
new file mode 100644
index 000000000000..5d258be97bf2
--- /dev/null
+++ b/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/input.js
@@ -0,0 +1,7 @@
+function run(str, r) {
+    let m
+    while (m = r.exec(str)) {
+        console.log(m)
+    }
+}
+run('abcda', /a/g)
\ No newline at end of file
diff --git a/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/output.js b/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/output.js
new file mode 100644
index 000000000000..40a73827977f
--- /dev/null
+++ b/crates/swc_ecma_minifier/tests/fixture/issues/6279/1/output.js
@@ -0,0 +1,4 @@
+!function(str, r) {
+    let m;
+    for(; m = r.exec(str);)console.log(m);
+}('abcda', /a/g);
diff --git a/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/input.js b/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/input.js
new file mode 100644
index 000000000000..edea710fec9d
--- /dev/null
+++ b/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/input.js
@@ -0,0 +1,8 @@
+const r = new RegExp('a', 'g');
+function run(str, r) {
+    let m
+    while (m = r.exec(str)) {
+        console.log(m)
+    }
+}
+run('abcda', r)
\ No newline at end of file
diff --git a/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/output.js b/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/output.js
new file mode 100644
index 000000000000..40a73827977f
--- /dev/null
+++ b/crates/swc_ecma_minifier/tests/fixture/issues/6279/2/output.js
@@ -0,0 +1,4 @@
+!function(str, r) {
+    let m;
+    for(; m = r.exec(str);)console.log(m);
+}('abcda', /a/g);