diff --git a/CHANGELOG.md b/CHANGELOG.md
index a6f63760dc3f..aec79153c6a3 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Fixed
 
 - Allow use of falsy values in theme config ([#6917](https://github.com/tailwindlabs/tailwindcss/pull/6917))
+- Ensure we can apply classes defined with non-"on-demandable" selectors ([#6922](https://github.com/tailwindlabs/tailwindcss/pull/6922))
 
 
 ## [3.0.11] - 2022-01-05
diff --git a/src/lib/setupContextUtils.js b/src/lib/setupContextUtils.js
index e75aefdbc6b0..f86f5e3d31d9 100644
--- a/src/lib/setupContextUtils.js
+++ b/src/lib/setupContextUtils.js
@@ -89,39 +89,55 @@ function getClasses(selector) {
   return parser.transformSync(selector)
 }
 
-function extractCandidates(node) {
+function extractCandidates(node, state = { containsNonOnDemandable: false }, depth = 0) {
   let classes = []
 
+  // Handle normal rules
   if (node.type === 'rule') {
     for (let selector of node.selectors) {
       let classCandidates = getClasses(selector)
       // At least one of the selectors contains non-"on-demandable" candidates.
-      if (classCandidates.length === 0) return []
+      if (classCandidates.length === 0) {
+        state.containsNonOnDemandable = true
+      }
 
-      classes = [...classes, ...classCandidates]
+      for (let classCandidate of classCandidates) {
+        classes.push(classCandidate)
+      }
     }
-    return classes
   }
 
-  if (node.type === 'atrule') {
+  // Handle at-rules (which contains nested rules)
+  else if (node.type === 'atrule') {
     node.walkRules((rule) => {
-      classes = [...classes, ...rule.selectors.flatMap((selector) => getClasses(selector))]
+      for (let classCandidate of rule.selectors.flatMap((selector) =>
+        getClasses(selector, state, depth + 1)
+      )) {
+        classes.push(classCandidate)
+      }
     })
   }
 
+  if (depth === 0) {
+    return [state.containsNonOnDemandable || classes.length === 0, classes]
+  }
+
   return classes
 }
 
 function withIdentifiers(styles) {
   return parseStyles(styles).flatMap((node) => {
     let nodeMap = new Map()
-    let candidates = extractCandidates(node)
+    let [containsNonOnDemandableSelectors, candidates] = extractCandidates(node)
 
-    // If this isn't "on-demandable", assign it a universal candidate.
-    if (candidates.length === 0) {
-      return [['*', node]]
+    // If this isn't "on-demandable", assign it a universal candidate to always include it.
+    if (containsNonOnDemandableSelectors) {
+      candidates.unshift('*')
     }
 
+    // However, it could be that it also contains "on-demandable" candidates.
+    // E.g.: `span, .foo {}`, in that case it should still be possible to use
+    // `@apply foo` for example.
     return candidates.map((c) => {
       if (!nodeMap.has(node)) {
         nodeMap.set(node, node)
diff --git a/tests/apply.test.js b/tests/apply.test.js
index ebba23526352..31b19bfa937e 100644
--- a/tests/apply.test.js
+++ b/tests/apply.test.js
@@ -812,6 +812,104 @@ it('should be possible to apply user css without tailwind directives', () => {
   })
 })
 
+it('should be possible to apply a class from another rule with multiple selectors (2 classes)', () => {
+  let config = {
+    content: [{ raw: html`<div class="c"></div>` }],
+    plugins: [],
+  }
+
+  let input = css`
+    @tailwind utilities;
+    @layer utilities {
+      .a,
+      .b {
+        @apply underline;
+      }
+
+      .c {
+        @apply b;
+      }
+    }
+  `
+
+  return run(input, config).then((result) => {
+    return expect(result.css).toMatchFormattedCss(css`
+      .c {
+        text-decoration-line: underline;
+      }
+    `)
+  })
+})
+
+it('should be possible to apply a class from another rule with multiple selectors (1 class, 1 tag)', () => {
+  let config = {
+    content: [{ raw: html`<div class="c"></div>` }],
+    plugins: [],
+  }
+
+  let input = css`
+    @tailwind utilities;
+
+    @layer utilities {
+      span,
+      .b {
+        @apply underline;
+      }
+
+      .c {
+        @apply b;
+      }
+    }
+  `
+
+  return run(input, config).then((result) => {
+    return expect(result.css).toMatchFormattedCss(css`
+      span,
+      .b {
+        text-decoration-line: underline;
+      }
+
+      .c {
+        text-decoration-line: underline;
+      }
+    `)
+  })
+})
+
+it('should be possible to apply a class from another rule with multiple selectors (1 class, 1 id)', () => {
+  let config = {
+    content: [{ raw: html`<div class="c"></div>` }],
+    plugins: [],
+  }
+
+  let input = css`
+    @tailwind utilities;
+    @layer utilities {
+      #a,
+      .b {
+        @apply underline;
+      }
+
+      .c {
+        @apply b;
+      }
+    }
+  `
+
+  return run(input, config).then((result) => {
+    return expect(result.css).toMatchFormattedCss(css`
+      #a,
+      .b {
+        text-decoration-line: underline;
+      }
+
+      .c {
+        text-decoration-line: underline;
+      }
+    `)
+  })
+})
+
 /*
 it('apply can emit defaults in isolated environments without @tailwind directives', () => {
   let config = {